|
Pneumonia
|
0.600 |
Biomarker
|
disease |
BEFREE |
A single GLA exposure (1 mg/kg) induced seizures and inflammatory cell recruitment in the broncho-alveolar space, and increased myeloperoxidase (MPO), inducible NO synthase (iNOS), interstitial inflammation and disruption of alveolar septae within 6-24 h. Interleukin 1β (IL-1β) was increased and lung inflammation depended on IL-1 receptor 1 (IL-1R1).
|
27549113 |
2016 |
|
Pneumonia
|
0.600 |
Biomarker
|
disease |
BEFREE |
TNB instillations in IL-1R null mice demonstrated the critical role of IL-1β in initiation of TNB-induced lung inflammation.
|
25179214 |
2014 |
|
Pneumonia
|
0.600 |
Biomarker
|
disease |
BEFREE |
The recombinant VPA/3446 virus also caused more severe pneumonia in Casp 1(-/-) mice than in IL1β(-/-) and wild-type B6 mice.
|
23901080 |
2013 |
|
Pneumonia
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The transgenic expression of IL-1β in the pulmonary epithelium causes lung inflammation and disrupts alveolar development in infant mice.
|
22865624 |
2012 |
|
Pneumonia
|
0.600 |
Biomarker
|
disease |
BEFREE |
The faster growing strains elicited more tumor necrosis factor α and interleukin 1β than the slower growing strains, even after heat killing, and caused accelerated death of infected guinea pigs (∼9 weeks vs 24 weeks) associated with increased lung inflammation/pathology.
|
22315279 |
2012 |
|
Pneumonia
|
0.600 |
Biomarker
|
disease |
CTD_human |
Expansion of CD4(+) CD25(+) and CD25(-) T-Bet, GATA-3, Foxp3 and RORγt cells in allergic inflammation, local lung distribution and chemokine gene expression.
|
21625544 |
2011 |
|
Pneumonia
|
0.600 |
Biomarker
|
disease |
RGD |
Early gestational intrauterine infection induces postnatal lung inflammation and arrests lung development in a rat model.
|
20476872 |
2011 |
|
Pneumonia
|
0.600 |
Biomarker
|
disease |
BEFREE |
Interleukin 1B (IL1B) is involved in pulmonary inflammation induced by environmental or occupational toxins.
|
20035239 |
2010 |
|
Pneumonia
|
0.600 |
Biomarker
|
disease |
BEFREE |
To study the hypothesis that MMP-9 is an important downstream mediator in IL-1 beta-induced lung injury in the newborn, we compared the effects of IL-1 beta on fetal and postnatal lung inflammation and development in transgenic mice with regulatable pulmonary overexpression of human mature IL-1 beta with wild-type (IL-1 beta/MMP-9(+/+)) or null (IL-1 beta/MMP-9(-/-)) MMP-9 loci.
|
19097983 |
2009 |
|
Pneumonia
|
0.600 |
Biomarker
|
disease |
LHGDN |
Enhanced IL-1beta-induced IL-8 production in cystic fibrosis lung epithelial cells is dependent of both mitogen-activated protein kinases and NF-kappaB signaling.
|
17420005 |
2007 |
|
Pneumonia
|
0.600 |
Biomarker
|
disease |
LHGDN |
Increased levels of pro-inflammatory cytokines, such as interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), have been correlated with lung inflammation.
|
17681786 |
2007 |
|
Pneumonia
|
0.600 |
Biomarker
|
disease |
BEFREE |
In conclusion, bleomycin-induced lung pathology required the inflammasome and IL-1R1/MyD88 signaling, and IL-1 represented a critical effector of pathology and therapeutic target of chronic lung inflammation and fibrosis.
|
17992263 |
2007 |
|
Pneumonia
|
0.600 |
Biomarker
|
disease |
BEFREE |
Interleukin-1beta causes pulmonary inflammation, emphysema, and airway remodeling in the adult murine lung.
|
15668323 |
2005 |
|
Pneumonia
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
This defect was associated with impaired neutrophilic lung inflammation 4 h after LPS challenge and diminished levels of TNF-alpha, IL-1 beta, macrophage inflammatory protein-2, and KC in lung homogenates.
|
15047567 |
2004 |
|
Pneumonia
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Fibrin enhances the expression of IL-1 beta by human peripheral blood mononuclear cells. Implications in pulmonary inflammation.
|
7836771 |
1995 |