|
Pneumonia
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Attenuation of lung inflammation indicative of acute lung injury, such as alveolar hemorrhage, interstitial thickening, and the presence of alveolar exudate, together with reduced levels of the inflammatory mediators TNFα, IL-1β, IL-6, KC, and MCP-1, strongly suggests amelioration of the pathological immune response in the lungs to promote resolution of the infection.
|
29516781 |
2018 |
|
Pneumonia
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
After pulmonary delivery of microparticles to Sprague-Dawley rats, the microparticles were uniformly distributed throughout the lung and were retained in the lungs until 48 h. Serum cytokine (TNF-α and IL-1β) levels of rats after induction of lung inflammation by lipopolysaccharide were measured until 72 h. Animals receiving ASO-loaded microparticles were successful in significantly controlling lung inflammation during this period as compared to animals receiving no treatment.
|
29663290 |
2018 |
|
Pneumonia
|
0.600 |
Biomarker
|
disease |
BEFREE |
The severity of pneumonia in mice caused by haze particulate was determined through imaging the activity of LTA<sub>4</sub>H as biomarker and confirmed using a commercial ELISA kit of interleukin-1β.
|
29682967 |
2018 |
|
Pneumonia
|
0.600 |
Biomarker
|
disease |
BEFREE |
While IFN-γ, IL-2, and TNF-α have been previously noted, the finding of elevated levels of the innate cytokines GM-CSF and IL-1β could suggest that these, as well as IL-13, are early and specific markers for pulmonary coccidioidomycosis.<b>IMPORTANCE</b> Coccidioidomycosis, commonly known as Valley fever, is a common pneumonia in the southwestern United States.
|
29769377 |
2018 |
|
Pneumonia
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We demonstrated that PFD remarkably ameliorated LPS-induced pulmonary inflammation and fibrosis and reduced IL-1β and TGF-β1 levels in bronchoalveolar lavage fluid(BALF).
|
29783158 |
2018 |
|
Pneumonia
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
AE inhibited PS colonization (p < 0.001) and lung inflammation (total cells, neutrophils, lymphocytes [p < 0.01] in bronchoalveolar lavage [BAL]), with significant differences in BAL levels of IL-1β (p < 0.001), IL-6 (p < 0.01), CXCL1 (p < 0.001), and TNF-α (p < 0.001), as well as parenchymal neutrophils (p < 0.001).
|
29843140 |
2018 |
|
Pneumonia
|
0.600 |
Biomarker
|
disease |
BEFREE |
Mice deficient for chromosome 3 GBPs were unable to mount a rapid IL-1/chemokine (C-X-C motif) ligand 1 (CXCL1) response during Legionella-induced pneumonia, with defective bacterial clearance.
|
29972777 |
2018 |
|
Pneumonia
|
0.600 |
Biomarker
|
disease |
BEFREE |
Collectively, our data suggest that microvesicles packaging IL-1β and TNF-α enhance lung inflammation in VILI.
|
30075431 |
2018 |
|
Pneumonia
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
After 21 days of exposure to PM<sub>2.5</sub> through oropharyngeal aspiration, Balb/c mice showed increased IL-1β and TGF-β1 levels in the bronchoalveolar lavage fluid (BALF) of lung and significant collagen deposition around small airways of mice, suggesting potential lung inflammation and pulmonary fibrosis.
|
30092543 |
2018 |
|
Pneumonia
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
However, blocking p38 MAPK signaling through the inhibitor SB203580 significantly suppressed the acute lung injury and excessive lung inflammation in vivo, consistent with the reduced expression of the NLRP3 inflammasome and IL‑1β and cleavage of caspase‑1.
|
30152849 |
2018 |
|
Pneumonia
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the influence of LPS-induced production of IL-1β and Rev-erbα on the development of lung inflammation.
|
31129418 |
2019 |
|
Pneumonia
|
0.600 |
Biomarker
|
disease |
BEFREE |
In vivo studies revealed that the indicators of pulmonary inflammation (pathology, inflammatory cell numbers) and related cytokines (IL-1β, IL-6, IL-33) mRNA expressions in CD11c-Map3k7<sup>-/-</sup> animals were significantly lower than wild-type animals after mice were instilled particles.
|
31330343 |
2019 |
|
Pneumonia
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Mice treated with PB10 alone survived lethal-dose intranasal ricin challenge, but experienced significant weight loss, moderate pulmonary inflammation (e.g., elevated IL-1 and IL-6 levels, PMN influx), and apoptosis of lung macrophages.
|
31589555 |
2019 |
|
Pneumonia
|
0.600 |
Biomarker
|
disease |
BEFREE |
We hypothesized that TLMPs trigger inflammasome activation and IL-1β production in bronchial and alveolar epithelial cells to induce airway and lung inflammation.
|
31759058 |
2020 |
|
Pneumonia
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Intratracheal instillation of nZnO intensively aggravated LPS-induced lung inflammation that was accompanied by enhanced expression of interleukin-1β, interleukin-6, monocyte chemotactic protein-1αand granulocyte-macrophage colony stimulating factor.
|
31804693 |
2020 |