|
Systemic Scleroderma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Increased interleukin 1 receptor, type I, at messenger RNA and protein level in skin fibroblasts from patients with systemic sclerosis.
|
1375465 |
1992 |
|
Choriocarcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Both p60 and p80 TNF-R mRNA were present in the choriocarcinoma cell lines, and DNA synthesis was inhibited by antibody to the p60 TNF-R.
|
8390539 |
1993 |
|
Lymphoma
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Then, to examine whether t(2;5)(p23;q35) was present on biopsied lymphomas, reverse transcriptase-polymerase chain reaction (RT-PCR) covering the fusion junction of p80 mRNA was performed.
|
7949120 |
1994 |
|
Adult Lymphoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
In this study, we intended to detect p80 on lymphoma tissues with immunologic methods.
|
7949120 |
1994 |
|
Childhood Lymphoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
In this study, we intended to detect p80 on lymphoma tissues with immunologic methods.
|
7949120 |
1994 |
|
Cyclic neutropenia
|
0.010 |
Biomarker
|
disease |
BEFREE |
These data suggest that cyclic hematopoiesis is caused by a defect in the G-CSF signal transduction pathway at a point distal to G-CSF receptor binding that does not involve the early biochemical events leading to p80 tyrosine phosphorylation.
|
7519075 |
1994 |
|
Juvenile Myelomonocytic Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
These data further support a central role for IL-1 beta in the pathogenesis of JCML and suggest that the use of IL-1 Ra could represent a novel therapeutic strategy against this disorder.
|
8286744 |
1994 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.240 |
GeneticVariation
|
disease |
BEFREE |
Characterization of polymorphisms of an interleukin 1 receptor type 1 gene (IL1RI) promotor region (P2) and their relation to insulin-dependent diabetes mellitus (IDDM). The Danish Study Group of Diabetes in Childhood.
|
8580383 |
1995 |
|
Graft-vs-Host Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
There were several exceptions in some cases and IL-1R expression was found to vary in a rather wide range, however, the expression of IL-2R and IL-6R mRNA tended to increase during the development of graft-versus-host disease (GVHD).
|
8535220 |
1995 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.240 |
GeneticVariation
|
disease |
BEFREE |
This study further demonstrates the genetic heterogeneity of disease susceptibility between and within populations and also supports the hypothesis of an interaction of the IL1R1 locus with genes within the HLA and insulin gene regions in the susceptibility to type 1 diabetes.
|
8911996 |
1996 |
|
Ki-1+ Anaplastic Large Cell Lymphoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
The NPM-ALK fusion transcript and the p80 protein were detected in eight of nine ALCL cell lines.
|
8558920 |
1996 |
|
Ki-1+ Anaplastic Large Cell Lymphoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
When paraffin sections of 105 cases of ALCL were stained using the anti-p80 antibody, 30 were shown to be p80 positive Clinicopathological comparison between p80-positive and p80-negative ALCLs revealed that the p80-positive cases occurred in a much younger patient age group and that the patients showed a far better 5-year survival rate.
|
9021682 |
1996 |
|
Ki-1+ Anaplastic Large Cell Lymphoma
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
However, the highest percentage (23 of 26 cases; 88.5%) of P80 positive cases was found in children compared with 60% (18 of 30 cases) in adult ALCL (P < .05).
|
8547653 |
1996 |
|
Diabetes
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
An association between type 1 diabetes and the interleukin-1 receptor type 1 gene. The DiMe Study Group. Childhood Diabetes in Finland.
|
8911996 |
1996 |
|
Diabetes Mellitus
|
0.010 |
GeneticVariation
|
group |
BEFREE |
An association between type 1 diabetes and the interleukin-1 receptor type 1 gene. The DiMe Study Group. Childhood Diabetes in Finland.
|
8911996 |
1996 |
|
Psoriasis
|
0.110 |
AlteredExpression
|
disease |
BEFREE |
In summary, this study provides a defined phenotype of the complete epidermal IL-1 system in psoriasis; it shows that the expressions of IL-1(R) isoforms are coordinately altered, resulting in a predominance of IL-1 antagonists, which may represent a negative feedback response to IL-1 agonists, leading to a decreased IL-1 responsiveness.
|
9058835 |
1997 |
|
Ki-1+ Anaplastic Large Cell Lymphoma
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
Conversely, the 24 p80- ALCL cases, in which epithelial membrane antigen (EMA) and bcl-2 positivities were 33% and 55%, respectively, were heterogeneous and could be subdivided into five different categories, namely (a) 11 cases of HD-like ALCLs, (b) six cases of p80 common ALCL, (c) three cases of secondary ALCL, (d) two cases of primary cutaneous ALCL, and (e) two cases of primary classical ALCL that lacked p80 expression.
|
9414185 |
1997 |
|
Ki-1+ Anaplastic Large Cell Lymphoma
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
A high percentage of extracutaneous CD30+ anaplastic large cell lymphomas (nodal ALCL) carry a specific chromosomal translocation, t(2;5) (p23;q35), that results in abnormal expression of p80 NPM/ALK chimeric protein (p80).
|
9449486 |
1997 |
|
Rheumatoid Arthritis
|
0.030 |
Biomarker
|
disease |
BEFREE |
Cartilage that was coimplanted with RA-SF transduced with a marker gene exhibited progressive, chondrocyte-mediated cartilage degradation, whereas no such degradation was observed in cartilage that was coimplanted with RA-SF transduced with IL-1 Ra.
|
9120311 |
1997 |
|
Lymphoproliferative Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
The t(2;5)-associated p80 NPM/ALK fusion protein in nodal and cutaneous CD30+ lymphoproliferative disorders.
|
9449486 |
1997 |
|
Lymphomatoid papulosis type A (CD-30 positive type)
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Although nodal ALCL, primary cutaneous ALCL, and lymphomatoid papulosis type A (lyp A) have similar histologic and immunohistochemical features, the expression of p80 in these cutaneous lesions has not been extensively studied.
|
9449486 |
1997 |
|
Alzheimer's Disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
Expression of DNA excision-repair-cross-complementing proteins p80 and p89 in brain of patients with Down Syndrome and Alzheimer's disease.
|
9714461 |
1998 |
|
Inflammatory Bowel Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
Interleukin 1 (IL-1) and its physiological antagonist interleukin-1 receptor antagonist (IL-1 ra) play a crucial role in the pathogenesis of inflammatory bowel disease.
|
9568467 |
1998 |
|
Congenital chromosomal disease
|
0.010 |
GeneticVariation
|
group |
BEFREE |
These in vitro studies have demonstrated that the proliferation is characterized by a unique chromosomal abnormality, the 5q35bp usually associated with a t(2;5) translocation generating a fusion gene NPM/ALK and the subsequent translation of p80 protein.
|
9561912 |
1998 |
|
Ulcerative Colitis
|
0.120 |
GeneticVariation
|
disease |
BEFREE |
Our data support the concept that CD and severe UC have a genetic disequilibrium in the distribution of IL1B and IL1RA gene polymorphisms.
|
10192196 |
1999 |