|
Stage IV Lung Cancer AJCC v8
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
CDH1 (encoding the epithelial cell marker E-cadherin) and IL2RA (encoding the Treg marker CD25) expression in patients with stage IV lung cancer that were resistant to cisplatin treatment showed an inverse correlation between IL2RA (high) and CDH1 (low) expression.
|
31066485 |
2019 |
|
Triple-Negative Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The predictive and prognostic value of Foxp3+/CD25+ regulatory T cells and PD-L1 expression in triple negative breast cancer.
|
31096176 |
2019 |
|
Primary Myelofibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
We reported that p40<sup>-/-</sup>IL-2Rα<sup>-/-</sup> (interleukin-12p40 and interleukin-2 receptor alpha double knockout) mice, a mouse model of human primary biliary cholangitis, exhibited features consistent with autoimmune myelofibrosis, including anemia associated with bone marrow fibrosis, and extramedullary hematopoiesis (EMH) including LSK (Lineage<sup>-</sup>c-Kit<sup>+</sup>Sca-1<sup>+</sup>) cells in spleen, liver and peripheral blood.
|
29307587 |
2018 |
|
Extrinsic allergic alveolitis
|
0.010 |
AlteredExpression
|
group |
BEFREE |
MSCs from HP did not reduce T-cell proliferation based on CFSE MFI values, while the level of CD25 expression on both control and HP-derived CD4+ and CD8+ T-cells was significantly reduced by normal MSCs, while HP-derived MSCs did not have any significant effect.
|
27792269 |
2018 |
|
Amyotrophic Lateral Sclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Interestingly, disease duration was the sole independent significant determining factor that predicted CD4+CD25+ regulatory T cell counts in the peripheral blood of patients at various stages of ALS, according to a logistic regression model.
|
29574662 |
2018 |
|
Cardiac Arrhythmia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, in the Cox proportional hazard analysis, cTnI, but not ACE, IL2R or BNP, was a predictor of fatal arrhythmia in sarcoidosis patients (HR 2.418, P = 0.003).Higher ACE and sIL2-R are associated with systemic lesions, whereas BNP is a useful marker for detecting cardiac involvement in sarcoidosis patients. cTnI is a predictor of fatal arrhythmia in CS patients.
|
30101857 |
2018 |
|
Malignant neoplasm of skin
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In addition to total Treg cells, the proportion of functionally distinct Treg cell subsets defined by CD45RA and CD27 phenotypic markers, graded expression of FOXP3 and CD25, and those expressing cutaneous lymphocyte-associated Ag and the chemokine receptor CCR4 were enumerated in 350 individuals undergoing routine skin cancer screening exams and determined not to have prevalent skin cancer.
|
30389774 |
2018 |
|
Mental Depression
|
0.010 |
Biomarker
|
disease |
BEFREE |
Two CS-specific Health Related Quality of Life (HRQL) measures were identified (i.e., CushingQoL, Tuebingen CD-25), as well as depression and neurocognitive measures.
|
30567582 |
2018 |
|
Depressive disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Two CS-specific Health Related Quality of Life (HRQL) measures were identified (i.e., CushingQoL, Tuebingen CD-25), as well as depression and neurocognitive measures.
|
30567582 |
2018 |
|
Eclampsia
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, a reduction in the frequencies of both CD4+ CD25+ Foxp3+ and CD8+CD25+Foxp3+ regulatory T cells might be important in the pathogenesis of pre-eclampsia.
|
30644698 |
2018 |
|
Hypertensive disease
|
0.010 |
Biomarker
|
group |
BEFREE |
More important, depletion of Tregs with CD25 antibody abolished the protective effects against Ang II-induced hypertension and target-organ damage in DKO mice.
|
29437833 |
2018 |
|
Hyperthyroidism
|
0.010 |
Biomarker
|
disease |
BEFREE |
PB CD4+CD25+ Tregs function was decreased in patients with hyperthyroidism, and its non‑proportional decrease may be closely associated with the occurrence and progression of hyperthyroidism.
|
29207121 |
2018 |
|
Leukemia, Mast-Cell
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Herein, we present a rare case of de novo MCL without CD25 expression and KIT mutations.
|
29458385 |
2018 |
|
Myelofibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
We reported that p40<sup>-/-</sup>IL-2Rα<sup>-/-</sup> (interleukin-12p40 and interleukin-2 receptor alpha double knockout) mice, a mouse model of human primary biliary cholangitis, exhibited features consistent with autoimmune myelofibrosis, including anemia associated with bone marrow fibrosis, and extramedullary hematopoiesis (EMH) including LSK (Lineage<sup>-</sup>c-Kit<sup>+</sup>Sca-1<sup>+</sup>) cells in spleen, liver and peripheral blood.
|
29307587 |
2018 |
|
Neuritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therapeutic Effect of CD4+CD25+ Regulatory T Cells Amplified In Vitro on Experimental Autoimmune Neuritis in Rats.
|
29772575 |
2018 |
|
Sarcoidosis, Pulmonary
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, induction of TLR-2 expression was found not only in Tregs, but also in the heterogeneous population of peripheral blood mononuclear cells (PBMC) as well as two PBMC subpopulations (CD4+/CD25-and CD4-/CD25-) of patients with PS.
|
30049532 |
2018 |
|
Miller Dieker syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
CD25 was over-expressed on HSC in MDS patients, especially in high-risk MDS patients.
|
29407181 |
2018 |
|
Tuberculosis of intestines
|
0.010 |
Biomarker
|
disease |
BEFREE |
CD4+ CD25+ FOXP3+ T cell frequency in the peripheral blood is a biomarker that distinguishes intestinal tuberculosis from Crohn's disease.
|
29489879 |
2018 |
|
Depressed mood
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Two CS-specific Health Related Quality of Life (HRQL) measures were identified (i.e., CushingQoL, Tuebingen CD-25), as well as depression and neurocognitive measures.
|
30567582 |
2018 |
|
Pregnancy associated hypertension
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
The serum levels of TGF-β, IL-10, IL-35, and Foxp3 mRNA expression and CD4+CD25+ Treg cell percentage in PBMCs were decreased in PIH.
|
29846432 |
2018 |
|
Leishmania donovani disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Along the above lines, the present study further evaluated the percentage of CD4+ CD25+ FoxP3+ T regulatory cells and ultra structural changes in kidney, liver and spleen.Cisplatin (5 mg/kg b.wt. daily for 5 days, i.p.) along with Tinosporacordifolia (100 mg/kg b.wt. daily for 15 days, p.o.) or Withaniasomnifera (350 mg/kg b.wt. daily for 15 days, p.o.) or Asparagusracemosus (650 mg/kg b.wt. daily for 15 days, p.o.) was administered to L. donovani infected BALB/c and after 30 days post treatment mice were sacrificed.
|
28655574 |
2018 |
|
Macrophage Activation Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
After extensive workup and lack of improvement with broad-spectrum antimicrobial therapy, intravenous immunoglobulin and steroids, the patient was diagnosed with macrophage activation syndrome after bone marrow biopsy and levels of soluble CD25 (soluble interleukin (IL)-2 receptor) and IL2 were obtained.
|
30061130 |
2018 |
|
Leprosy, Paucibacillary
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, IL2RA is a positional candidate gene because it is located near the 10p13 chromosome region, presenting a linkage peak for PB leprosy.
|
30540075 |
2018 |
|
SVEINSSON CHORIORETINAL ATROPHY
|
0.010 |
Biomarker
|
disease |
BEFREE |
A possible association between HLA-DRB1*11 alleles as well as a single variation in PTPN22, CTLA4, and IL2RA genes and patchy AA disease have been investigated in a cohort from Iran.
|
29979892 |
2018 |
|
Extramedullary Hematopoiesis (disorder)
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We reported that p40<sup>-/-</sup>IL-2Rα<sup>-/-</sup> (interleukin-12p40 and interleukin-2 receptor alpha double knockout) mice, a mouse model of human primary biliary cholangitis, exhibited features consistent with autoimmune myelofibrosis, including anemia associated with bone marrow fibrosis, and extramedullary hematopoiesis (EMH) including LSK (Lineage<sup>-</sup>c-Kit<sup>+</sup>Sca-1<sup>+</sup>) cells in spleen, liver and peripheral blood.
|
29307587 |
2018 |