IL2RA, interleukin 2 receptor subunit alpha, 3559

N. diseases: 540; N. variants: 43
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4284413
Disease: Severe Fever with Thrombocytopenia Syndrome
Severe Fever with Thrombocytopenia Syndrome 		0.010 AlteredExpression disease BEFREE The expression levels of apoptotic markers (annexin V and CD95) and proliferation and activation markers (Ki-67, HLA-DR, and CD25) and the expression levels of programmed cell death-1 (PD-1), interferon gamma (IFN-γ), and granzyme B in T cells were evaluated by flow cytometry for the SFTS patients. 29550447 2018
CUI: C0001339
Disease: Acute pancreatitis
Acute pancreatitis 		0.010 Biomarker disease BEFREE Increased Circulating CD4+CD25+CD127low/neg Regulatory T-cells as a Prognostic Biomarker in Acute Pancreatitis. 28787335 2017
CUI: C0002792
Disease: anaphylaxis
anaphylaxis 		0.010 Biomarker phenotype BEFREE Increased levels of Tregs in the MLN and abolished protection against signs of anaphylaxis upon transfer of CD25-depleted cell fractions, suggest a role for Foxp3+ Tregs in the protective effect of OIT + FOS. 29033945 2017
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases 		0.010 Biomarker group BEFREE Early randomized trials showed that rATG or IL2RA induction reduces early acute rejection, prompting recommendations by Kidney Disease Improving Global Outcomes that IL2RA induction be used routinely in first-line therapy after kidney transplantation, with lymphocyte-depleting induction reserved for high-risk cases. 27223882 2017
CUI: C0023348
Disease: Leprosy, Lepromatous
Leprosy, Lepromatous 		0.010 AlteredExpression disease BEFREE The expression of CD25 on CD4+ and CD8+ T-cells was not significantly different in ENL and LL controls suggesting that CD25 expression is not associated with ENL reactions while FoxP3 expression on CD4+ T-cells was significantly lower in patients with ENL than in LL controls. 28991896 2017
CUI: C0024793
Disease: Marek Disease
Marek Disease 		0.010 Biomarker disease BEFREE A second lumbar puncture demonstrated a large number of lymphoid B cells, with positive immunohistochemical staining for CD20 and CD25, proving the diagnosis of neurolymphomatosis. 28288046 2017
CUI: C0031039
Disease: Pericardial effusion
Pericardial effusion 		0.010 AlteredExpression disease BEFREE Surface expression of cellular activation markers CD25 and Foxp3 in the pericardial fluid was increased in patients with CHF. 28565777 2017
CUI: C0035222
Disease: Respiratory Distress Syndrome, Adult
Respiratory Distress Syndrome, Adult 		0.010 Biomarker disease BEFREE These results demonstrate that the p55-targeting dAb attenuates lung injury and edema formation in models of ARDS induced by acid aspiration, with protection from a single dose lasting up to 24 h. Together with our previous data, the current study lends support toward the clinical targeting of p55 for patients with, or at risk of ARDS. 28243236 2017
CUI: C0242647
Disease: Mucosa-Associated Lymphoid Tissue Lymphoma
Mucosa-Associated Lymphoid Tissue Lymphoma 		0.010 AlteredExpression disease BEFREE Expression of CD25 and CD19 was higher in patients with orbital MALT lymphoma compared to patients with IgG4-ROD (p < 0.001). 28421369 2017
CUI: C0280100
Disease: Solid Neoplasm
Solid Neoplasm 		0.010 Biomarker phenotype BEFREE These preclinical data support the ongoing clinical investigation of the cergutuzumab amunaleukin immunocytokine with abolished CD25 binding for the treatment of CEA-positive solid tumors in combination with PD-L1 checkpoint blockade and ADCC competent antibodies. 28405498 2017
CUI: C0339143
Disease: Thyroid associated opthalmopathies
Thyroid associated opthalmopathies 		0.010 Biomarker disease BEFREE Decreased Frequencies of Peripheral Blood CD4+CD25+CD127-Foxp3+ in Patients with Graves' Disease and Graves' Orbitopathy: Enhancing Effect of Insulin Growth Factor-1 on Treg Cells. 28222462 2017
CUI: C0339573
Disease: Glaucoma, Primary Open Angle
Glaucoma, Primary Open Angle 		0.010 Biomarker disease BEFREE To gather first results concerning Treg levels in glaucoma patients, we aimed to investigate whether the number of CD4(+)CD25(+)T cells vary in the patients suffering from primary open-angle glaucoma (POAG) and healthy controls. 27723363 2017
CUI: C0343466
Disease: Type 2 lepra reaction
Type 2 lepra reaction 		0.010 AlteredExpression disease BEFREE The expression of CD25 on CD4+ and CD8+ T-cells was not significantly different in ENL and LL controls suggesting that CD25 expression is not associated with ENL reactions while FoxP3 expression on CD4+ T-cells was significantly lower in patients with ENL than in LL controls. 28991896 2017
CUI: C0343467
Disease: Erythema nodosum leprosum
Erythema nodosum leprosum 		0.010 AlteredExpression phenotype BEFREE The expression of CD25 on CD4+ and CD8+ T-cells was not significantly different in ENL and LL controls suggesting that CD25 expression is not associated with ENL reactions while FoxP3 expression on CD4+ T-cells was significantly lower in patients with ENL than in LL controls. 28991896 2017
CUI: C0524851
Disease: Neurodegenerative Disorders
Neurodegenerative Disorders 		0.010 Biomarker group BEFREE This study demonstrates increased numbers of CD4(+)CD25(+) T cells in the patients suffering from the neurodegenerative disease glaucoma. 27723363 2017
CUI: C0699949
Disease: airway disease
airway disease 		0.010 Biomarker disease BEFREE These results suggest that pitavastatin has potential as a therapy for allergic airway disease and that its effects are associated with its ability to regulate CD4+ CD25+ Foxp3+ T cell counts. 28729731 2017
CUI: C1274297
Disease: Febrile Ulceronecrotic Mucha-Habermann disease
Febrile Ulceronecrotic Mucha-Habermann disease 		0.010 Biomarker disease BEFREE This report describes a severe case of FUMHD-like eruption associated with clonal leukemic cells that improved with basiliximab, suggesting anti-CD25 therapy as a novel treatment for ulceronecrotic skin disease in the setting of high interleukin-2 levels. 28884915 2017
CUI: C1292778
Disease: Chronic myeloproliferative disorder
Chronic myeloproliferative disorder 		0.010 AlteredExpression disease BEFREE CD25 expression was increased at relapse and in the development of leukemic status from myelodysplastic syndrome or myeloproliferative neoplasm. 28097942 2017
CUI: C1335302
Disease: Pancreatic Ductal Adenocarcinoma
Pancreatic Ductal Adenocarcinoma 		0.010 Biomarker disease BEFREE CD25-expressing Th17 cells mediate CD8<sup>+</sup> T cell suppression in CTLA-4 dependent mechanisms in pancreatic ductal adenocarcinoma. 28942020 2017
CUI: C1850900
Disease: Familial primary gastric lymphoma
Familial primary gastric lymphoma 		0.010 AlteredExpression disease BEFREE Expression of CD25 and CD19 was higher in patients with orbital MALT lymphoma compared to patients with IgG4-ROD (p < 0.001). 28421369 2017
CUI: C2347761
Disease: Childhood Myelodysplastic Syndrome
Childhood Myelodysplastic Syndrome 		0.010 AlteredExpression disease BEFREE CD25 expression was increased at relapse and in the development of leukemic status from myelodysplastic syndrome or myeloproliferative neoplasm. 28097942 2017
CUI: C3695086
Disease: Symptomatic carotid artery stenosis
Symptomatic carotid artery stenosis 		0.010 Biomarker disease BEFREE Regulatory T CD4 + CD25+ lymphocytes increase in symptomatic carotid artery stenosis. 27690642 2017
CUI: C3900098
Disease: Adult Myelodysplastic Syndrome
Adult Myelodysplastic Syndrome 		0.010 AlteredExpression disease BEFREE CD25 expression was increased at relapse and in the development of leukemic status from myelodysplastic syndrome or myeloproliferative neoplasm. 28097942 2017
CUI: C4543926
Disease: Narcolepsy type 1
Narcolepsy type 1 		0.010 AlteredExpression disease BEFREE We demonstrated an increased number of central memory CD4+ T cells (CD62L+ CD45RA-) associated to an activated phenotype (increase in CD69 and CD25 expression) in NT1 patients. 28107375 2017
CUI: C4553088
Disease: Neurolymphomatosis
Neurolymphomatosis 		0.010 Biomarker disease BEFREE A second lumbar puncture demonstrated a large number of lymphoid B cells, with positive immunohistochemical staining for CD20 and CD25, proving the diagnosis of neurolymphomatosis. 28288046 2017