IL5, interleukin 5, 3567

N. diseases: 359; N. variants: 9
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0740302
Disease: 5q-syndrome
5q-syndrome 		0.010 Biomarker disease BEFREE Interleukin-5 is at 5q31 and is deleted in the 5q- syndrome. 3258537 1988
CUI: C1292779
Disease: Myelodysplastic Syndrome with Isolated del(5q)
Myelodysplastic Syndrome with Isolated del(5q) 		0.010 Biomarker disease BEFREE Interleukin-5 is at 5q31 and is deleted in the 5q- syndrome. 3258537 1988
CUI: C1802398
Disease: Chromosome 5, trisomy 5q
Chromosome 5, trisomy 5q 		0.010 Biomarker disease BEFREE Interleukin-5 is at 5q31 and is deleted in the 5q- syndrome. 3258537 1988
CUI: C0002893
Disease: Refractory anemias
Refractory anemias 		0.010 Biomarker disease BEFREE By in situ hybridization, the IL-4 and IL-5 genes were found to be deleted in the 5q- chromosome of four patients with refractory anemia (RA) or therapy-related acute nonlymphocytic leukemia (t-ANLL), who had a del(5q). 2783863 1989
CUI: C0014457
Disease: Eosinophilia
Eosinophilia 		0.600 Biomarker disease BEFREE To determine if interleukin-5 (IL-5) is implicated in producing the eosinophilia, we performed in situ hybridization studies on cytopreparations of 16 cases of Hodgkin's disease with eosinophilia as well as cells from various controls. 2403816 1990
CUI: C0014457
Disease: Eosinophilia
Eosinophilia 		0.600 Biomarker disease BEFREE These findings suggest a possible expanded role for the B cell in the induction of eosinophilia, and should serve as a focus for additional investigation into possible roles for IL-5 in human B-cell proliferation and differentiation. 2156579 1990
CUI: C1306759
Disease: Eosinophilic disorder
Eosinophilic disorder 		0.100 Biomarker group BEFREE To determine if interleukin-5 (IL-5) is implicated in producing the eosinophilia, we performed in situ hybridization studies on cytopreparations of 16 cases of Hodgkin's disease with eosinophilia as well as cells from various controls. 2403816 1990
CUI: C1306759
Disease: Eosinophilic disorder
Eosinophilic disorder 		0.100 Biomarker group BEFREE These findings suggest a possible expanded role for the B cell in the induction of eosinophilia, and should serve as a focus for additional investigation into possible roles for IL-5 in human B-cell proliferation and differentiation. 2156579 1990
CUI: C0019829
Disease: Hodgkin Disease
Hodgkin Disease 		0.060 Biomarker disease BEFREE To determine if interleukin-5 (IL-5) is implicated in producing the eosinophilia, we performed in situ hybridization studies on cytopreparations of 16 cases of Hodgkin's disease with eosinophilia as well as cells from various controls. 2403816 1990
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.060 Biomarker disease BEFREE In vitro differentiation of leukemic cells to eosinophils in the presence of interleukin-5 in two cases of acute myeloid leukemia with the translocation (8;21)(q22;q22). 1688504 1990
CUI: C4049006
Disease: Selective immunoglobulin A deficiency
Selective immunoglobulin A deficiency 		0.020 Biomarker disease BEFREE We have analysed the frequency of IL-5 mRNA-producing cells in healthy adults and in patients with common variable immunodeficiency or selective IgA deficiency. 2397611 1990
CUI: C0009447
Disease: Common Variable Immunodeficiency
Common Variable Immunodeficiency 		0.010 Biomarker disease BEFREE We have analysed the frequency of IL-5 mRNA-producing cells in healthy adults and in patients with common variable immunodeficiency or selective IgA deficiency. 2397611 1990
CUI: C0026985
Disease: Myelodysplasia
Myelodysplasia 		0.010 GeneticVariation disease BEFREE The extent of such stepwise deletions, resulting in loss of genes such as interleukin-3 (IL-3), IL-4, IL-5, and GM-CSF, whose gene products are critical to differentiation within the lineage of the affected hematopoietic stem cell, may be mirrored in the heterogeneity of symptoms and 5q- deletion sizes observed in myelodysplasias and acute leukemias carrying a 5q- chromosome. 2403822 1990
CUI: C0745242
Disease: Immunoglobulin deficiency
Immunoglobulin deficiency 		0.010 Biomarker disease BEFREE Thus, although IL-5 has been reported to be an important regulator of IgA synthesis, a defect production does not seem to be the underlying mechanism in human immunoglobulin deficiency. 2397611 1990
CUI: C2936664
Disease: Acquired Hypogammaglobulinemia
Acquired Hypogammaglobulinemia 		0.010 Biomarker disease BEFREE We have analysed the frequency of IL-5 mRNA-producing cells in healthy adults and in patients with common variable immunodeficiency or selective IgA deficiency. 2397611 1990
CUI: C0004096
Disease: Asthma
Asthma 		0.700 AlteredExpression disease BEFREE This study provides evidence for the cellular localization of IL-5 mRNA in the bronchial mucosa of asthmatics and supports the concept that this cytokine regulates eosinophil function in bronchial asthma. 2022726 1991
CUI: C0014457
Disease: Eosinophilia
Eosinophilia 		0.600 AlteredExpression disease BEFREE The induction of detectable levels of IL-5 and GM-CSF in the circulation may explain the eosinophilia and neutrophilia observed in these patients. 1912580 1991
CUI: C0014457
Disease: Eosinophilia
Eosinophilia 		0.600 Biomarker disease CTD_human Transgenic mice expressing a B cell growth and differentiation factor gene (interleukin 5) develop eosinophilia and autoantibody production. 1988543 1991
CUI: C0014458
Disease: Eosinophilia, Tropical
Eosinophilia, Tropical 		0.310 Biomarker disease CTD_human Transgenic mice expressing a B cell growth and differentiation factor gene (interleukin 5) develop eosinophilia and autoantibody production. 1988543 1991
CUI: C1306759
Disease: Eosinophilic disorder
Eosinophilic disorder 		0.100 AlteredExpression group BEFREE The induction of detectable levels of IL-5 and GM-CSF in the circulation may explain the eosinophilia and neutrophilia observed in these patients. 1912580 1991
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.060 Biomarker disease BEFREE It is concluded that IL-5 responsive AML represents a subgroup of leukemia with distinct immunotypic and cytogenetic features. 1715959 1991
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas 		0.030 Biomarker group BEFREE Certain sub-lines of the murine B cell lymphoma BCL1 can be maintained in vitro and respond to cytokines including IL-2 and IL-5. 1765644 1991
CUI: C3665444
Disease: Neutrophilia (disorder)
Neutrophilia (disorder) 		0.030 AlteredExpression disease BEFREE The induction of detectable levels of IL-5 and GM-CSF in the circulation may explain the eosinophilia and neutrophilia observed in these patients. 1912580 1991
CUI: C0023418
Disease: leukemia
leukemia 		0.020 Biomarker disease BEFREE It is concluded that IL-5 responsive AML represents a subgroup of leukemia with distinct immunotypic and cytogenetic features. 1715959 1991
CUI: C0008626
Disease: Congenital chromosomal disease
Congenital chromosomal disease 		0.010 GeneticVariation group BEFREE All cases (n = 7) with the cytogenetic abnormality t(8;21)(q22;q22) belonged to this group of IL-5 responders. 1715959 1991