Dental caries
|
0.010 |
Biomarker
|
disease |
BEFREE |
We measured the levels of child blood Pb, salivary sialic acid, serum interleukin-6 (IL-6) and serum tumor necrosis factor-α (TNF-α), and investigated the prevalence of dental caries in deciduous teeth.
|
31678878 |
2020 |
Histiocytosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
To explore the pathogenesis that TIMP-1 mediated in adult orbital xanthogranulomatous disease (AOXGD), a rare type of non-Langerhans histiocytosis that damages the appearance and quality of life of patients Methods: We reviewed 22 patients diagnosed with AOXGD based on clinical manifestations and histological analysis, and then investigated the expression of TIMP-1 and IL-6 with q-PCR and IHC in AOXGD tissues and the possible mechanism involved in the induction of TIMP-1 by IL-6.
|
30973282 |
2020 |
Retinitis Pigmentosa
|
0.010 |
Biomarker
|
disease |
BEFREE |
Twelve cytokines (IL-1α, IL-1β, IL-4, IL-10, TNF-α, IFN-γ, EGF, GM-CSF, PDGF-AB/BB, TGF-α, BMP-9, and E-selection) were below the limit of detection, and the detection rate of IL-6 was significantly higher in RP group than in the ARC group (P < 0.01).
|
31810025 |
2020 |
Lower respiratory tract infection
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Compared with healthy controls, NGAL and IL-6 levels were significantly increased in the patients with LRTIs, the area under the curves (AUC) was 0.97 and 0.88 respectively (P < 0.01).
|
31672649 |
2020 |
Portal Vein Thrombosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The correlation between the interleukin 6 level and portal vein thrombosis requires further investigation.
|
31356372 |
2020 |
Ruptured cerebral aneurysm
|
0.010 |
Biomarker
|
disease |
BEFREE |
IL-6 is increased in the serum of estrogen-deficient mice and appears to play a role in promoting murine estrogen deficiency-associated cerebral aneurysm rupture via enhanced macrophage infiltration at the circle of Willis.
|
31264696 |
2020 |
Laryngomalacia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Laryngomalacia could be an inflammatory disease due to 25(OH)-vitamin D deficiency as evidenced by the high level of IL-6.
|
30972761 |
2020 |
Juvenile disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Response to IL-1 blockade was assessed by (1) clinical response (at least initial response compared to poor response), (2) switch to anti-IL-6 receptor therapy following IL-1 blockade or not (3) clinically inactive disease within 6 months of IL-1 blockade, (4) modified juvenile disease activity score and (5) reaching of a glucocorticoid free state.
|
31599092 |
2020 |
Malignant neoplasm of colon stage IV
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therefore, the aim of this study was coupling of CP with saturated and unsaturated fatty acids, and evaluation of their cytotoxicity, apoptosis-inducing effects and inhibition of IL-6 release in human primary (SW480) and metastatic (SW620) colon cancer, metastatic prostate cancer (PC3) and normal (HaCaT) cell lines.
|
31678743 |
2020 |
Histiocytic syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
To explore the pathogenesis that TIMP-1 mediated in adult orbital xanthogranulomatous disease (AOXGD), a rare type of non-Langerhans histiocytosis that damages the appearance and quality of life of patients Methods: We reviewed 22 patients diagnosed with AOXGD based on clinical manifestations and histological analysis, and then investigated the expression of TIMP-1 and IL-6 with q-PCR and IHC in AOXGD tissues and the possible mechanism involved in the induction of TIMP-1 by IL-6.
|
30973282 |
2020 |
Transfusion-Related Acute Lung Injury
|
0.010 |
Biomarker
|
disease |
BEFREE |
We confirmed that TRALI progress is accompanied by IL-6 activation in AMs.
|
31782162 |
2020 |
Unbearable Pain
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Constitutive expression of proinflammatory cytokines such as IL-3 and IL-6 causes organ damage and unbearable pain.
|
31755797 |
2020 |
Peripheral spondyloarthritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
MIF, TNF-α, and IL-6 concentrations in cell supernatants of AS PBMCs were significantly higher than those of pSpA and control PBMCs. miR-451 expression level did not show significant correlation with clinical parameters, but MIF expression level was elevated in PBMCs from AS patients with high mSASSS (12 or more).
|
31287414 |
2020 |
IgE-mediated food allergy
|
0.010 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to investigate the utility of serum biomarkers like interleukin (IL)-10, TNF-α, and IL-6 in the diagnosis and/or follow-up of FA.
|
31732222 |
2020 |
Acanthosis Nigricans
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moreover, FINS, HOMA-IR, TT and IL-6 levels were changed more in the AN group than those in the OB group.
|
30724385 |
2019 |
Alcoholic Intoxication
|
0.010 |
Biomarker
|
disease |
BEFREE |
The influence of central interleukin-6 on behavioral changes associated with acute alcohol intoxication in adult male rats.
|
30472309 |
2019 |
Alexithymia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
We therefore obtained inflammatory parameter data (C-reactive protein and interleukin-6), pruritus data and psychological test data (36-Item Short-Form Health Survey, "Allgemeine Depressionsskala" and Toronto Alexithymia Scale-20) for 19 dialysis patients with pruritus, 20 dialysis patients without pruritus and 15 healthy controls.
|
30673107 |
2019 |
Anuria
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Patients in the high IL-6 group had higher in-hospital 90-day mortality (low vs. middle vs. high, P = 0.0050), lower urine output (low vs. middle vs. high, P < 0.0001), and an increased probability of persistent of anuria for ≥12 h (low vs. middle vs. high, P < 0.0001) within 72 h after ICU admission.
|
30823904 |
2019 |
Behavioral Symptoms
|
0.010 |
Biomarker
|
group |
BEFREE |
DEX also reversed the progressive increase in intensity of the behavioral symptoms and reversed 6-OHDA- induced overproduction of TNF-α and IL-6.
|
31476326 |
2019 |
Blastomycosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
We validated differences in cytokine production between Hmong and European volunteers and formally demonstrated a critical role for IL-6 in the development of adaptive immunity to <i>Blastomyces dermatitidis</i> Our findings suggest that the dysregulation of IL-17 responses underlies a recently reported and poorly understood ethnic health disparity.<b>IMPORTANCE</b> Blastomycosis is a potentially life-threatening infection caused by the fungus <i>Blastomyces dermatitidis</i> As with related fungal diseases, blastomycosis is noted to affect some populations more than others.
|
31213563 |
2019 |
Bronchiolitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Indeed, elevated levels of IL-6, IL-8 (CXCL8), CCL2, and CCL4 have been reported in cerebrospinal fluid from patients with severe bronchiolitis and hRSV-associated encephalopathy.
|
30936869 |
2019 |
Cardiomyopathy, Dilated
|
0.010 |
Biomarker
|
group |
BEFREE |
To investigate the effect of interleukin-6 (IL-6) gene knockout on apoptosis of myocardial cells in mice with Coxsackievirus B3 (CVB3)-induced dilated cardiomyopathy (DCM) and its potential mechanism, so as to provide certain references for the clinical prevention and treatment of DCM.
|
31002169 |
2019 |
Cerebrovascular Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Effect of Interventional Therapy on IL-1β, IL-6, and Neutrophil-Lymphocyte Ratio (NLR) Levels and Outcomes in Patients with Ischemic Cerebrovascular Disease.
|
30664615 |
2019 |
Connective Tissue Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Systemic sclerosis (SSc) is a connective tissue disease, the pathogenesis of which is thought to involve interleukin-6 (IL-6), an inflammatory cytokine.
|
30561237 |
2019 |
Contact Dermatitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
DDRC ameliorated skin lesions such as crust, scales, incrustation and petechiae, and lowered erythema index on skin surface in CD miceDDRC inhibited enlargement of dorsal skin and prevented epidermal hyperplasia, hyperkeratosis, and spongiotic changes in inflamed tissuesDDRC reduced the levels of TNF-α, IFN-γ, and IL-6 in inflamed tissues of CD miceDDRC did not affect spleen/body weight ratio in CD mice.
|
28839376 |
2019 |