Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
BEFREE |
Vitronectin mitigates stroke-increased neurogenesis only in female mice and through FAK-regulated IL-6.
|
31678139 |
2020 |
Cerebrovascular accident
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Administration of a specific Nln inhibitor Agaricoglyceride A (AgaA) to mice after stroke in a middle cerebral artery occlusion model, dose-dependently aggravated injury measured by increased infarct and edema volumes, blood-brain barrier disruption, increased levels of interleukin 6 and monocyte chemoattractant protein-1, neurological and motor deficit 24 h after stroke.
|
31486527 |
2020 |
Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
BEFREE |
We hypothesized that serum concentrations of interleukin-6 (IL6) and lipoprotein-associated phospholipase A2 (LpPLA2) were inversely associated with long-term functional decline independently of vascular risk factors, stroke and myocardial infarction (MI) occurring during follow-up.
|
30934019 |
2019 |
Cerebrovascular accident
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Patients in the stroke group had higher levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) (391 pg/ml (107-1249) vs 109 (46-236); p = 0.003), interleukin 6 (2.6 pg/ml (0.8-8.1) vs 0.7 (0.4-1.2) p = 0.002) and asymmetric dimethylarginine (ADMA) (0.44 μmol/L (0.39-0.55) vs 0.36 (0.32-0.4); p = 0.0002) than the control group.
|
31260841 |
2019 |
Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
BEFREE |
In conclusion, IL-6 released after stroke, which is enhanced by wt-tPA through activation of NMDA-Rs and upregulation of ET-1 and JNK, impairs cerebrovascular autoregulation and increases histopathology.
|
29476447 |
2019 |
Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
BEFREE |
Mediation analyses showed that IL-6 mediated the black-white disparity in stroke risk, but mediation was via IL-6 associations with stroke risk factors.
|
31004072 |
2019 |
Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
BEFREE |
The astrocytic IL-6 was essential to the promoting effects of hyperforin on the neural precursor cells proliferation, neuronal differentiation, angiogenesis, and functional recovery after stroke.
|
31133816 |
2019 |
Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
BEFREE |
The strongest association occurred between IL-1α, IL-6 and recurrent stroke, other vascular events and death.
|
30844663 |
2019 |
Cerebrovascular accident
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Factors with an independent influence on the neurological status on the first day of stroke were: sex, WBC, total blood platelet (PLT) count, CRP, S100B and IL-6 levels.
|
31356182 |
2019 |
Cerebrovascular accident
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Female sex, older age, diabetes mellitus, atrial fibrillation, stroke-associated pneumonia (SAP) and higher National Institute of Health Stroke Scale (NIHSS) score as well as lower mHLA-DR levels, higher IL-6 and LBP-levels at day 1 were associated with poor outcome at 3 months in bivariate analysis.
|
31269910 |
2019 |
Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
BEFREE |
IL-6 was directly related to CHD, CVD and CUORE scores at V1 and with MI and STROKE at V2.
|
29953477 |
2018 |
Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
BEFREE |
When dividing PAH patients by median IL-6 level, patients with higher IL-6 had significantly worse RV function (fractional area change [FAC] 23 ± 12% vs 38 ± 11%, tricuspid annular plane systolic excursion [TAPSE] 1.3 ± 0.3 cm vs 2.1 ± 0.5 cm), impaired RV-PA coupling (0.6 ± 0.5%/mm Hg vs 0.9 ± 0.5%/mm Hg), higher right atrial pressure (13 ± 7 mm Hg vs 9 ± 5 mm Hg), reduced cardiac index (2.0 ± 0.5 liters/min/m<sup>2</sup> vs 2.8 ± 1.0 liters/min/m<sup>2</sup>) and lower stroke volume (48 ± 20 ml vs 70 ± 28 ml).
|
28893516 |
2018 |
Cerebrovascular accident
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Unstimulated macrophages isolated from naïve rats only upregulated expression of TNF-α and IL-6 following exposure to serum from Stroke rats.
|
30290827 |
2018 |
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Stroke recurrence rates in patients with different genotypes of IL-6 promoter were evaluated by 1-year follow-up.
|
29091301 |
2018 |
Cerebrovascular accident
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Although the prognostic value of IL6 is limited for the prediction of CHD events, it may have a role for the prediction of stroke, HF and all-cause death in asymptomatic statin users.
|
30312930 |
2018 |
Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
BEFREE |
The relationships among leukocyte numbers, cortisol, adrenocorticotropic hormone, interleukin-6, and metanephrines were assessed at 72 hours after stroke.
|
29097060 |
2018 |
Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
BEFREE |
Still, the therapeutic potential of IL-6 after experimental stroke has not yet been investigated in a clinically relevant way.
|
28587928 |
2017 |
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Herein we investigated, for the first time, the association of genetic polymorphisms of IL-6, CDKN2A- CDKN2B and other genes with ischemic stroke among indigenous West African participants in the Stroke Investigative Research and Education Network (SIREN) Study.
|
28716248 |
2017 |
Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
BEFREE |
In this large cohort of patients with acute ischemic stroke, IL-6 and NT-proBNP at admission were strong and independent prognostic markers for 90-day all-cause mortality, and provided complementary prognostic information to the routinely used stroke severity score NIHSS.
|
28348074 |
2017 |
Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
BEFREE |
Quantitative PCR analysis of whole cell lysate as well as flow-sorted myeloid cells from the perilesional cortex showed increased cellular interleukin 1 beta (IL-1β), interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-α) mRNA levels but reduced plasma levels of these cytokines in MS P2X4R KO mice after stroke.
|
28751018 |
2017 |
Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
BEFREE |
IL-6 was significantly increased in plasma (P=0.04) and CSF (P=0.04) in stroke dogs compared with healthy controls.
|
28079628 |
2017 |
Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
BEFREE |
By comparing the serum levels of inflammatory biomarkers, it was observed that IL‑6 and B1R levels tended to decline whereas IL‑10 levels increased in stroke patients from <30 days to over 180 days.
|
28990089 |
2017 |
Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
BEFREE |
Integrating IL-6 and Lp-PLA2 into the models can significantly enhance the risk prediction accuracy of primary stroke.
|
28917588 |
2017 |
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Our results indicate that IL-6 promoter -174 polymorphisms may play a role in susceptibility to stroke, but not stroke outcome.
|
27049557 |
2016 |
Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
BEFREE |
Our findings have implications for the use of cancer therapies that target VEGF or IL6 and for understanding abnormal angiogenesis in cancers, chronic inflammatory disease, and stroke.
|
26081809 |
2015 |