IL6, interleukin 6, 3569

N. diseases: 2367; N. variants: 22
Disease: Cytokine storm ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0919747
Disease: Cytokine storm
Cytokine storm 		0.090 Biomarker disease BEFREE Patients of all ages present with either a solitary enlarged lymph node (unicentric CD) or multicentric lymphadenopathy (MCD) with systemic inflammation, cytopenias, and life-threatening multiple organ dysfunction resulting from a cytokine storm often driven by interleukin 6 (IL-6). 30504327 2018
CUI: C0919747
Disease: Cytokine storm
Cytokine storm 		0.090 Biomarker disease BEFREE Analysis of inflammatory cytokines revealed a strong increase of interferon (IFN)-α and IFN-β, as well as interleukin-6, suggesting a possible role of type-I IFN in the cytokine storm, which may be correlated with unfavorable prognosis of CHIKV infection. 30539034 2018
CUI: C0919747
Disease: Cytokine storm
Cytokine storm 		0.090 Biomarker disease BEFREE Patients of all ages present with either a solitary enlarged lymph node (unicentric CD) or multicentric lymphadenopathy (MCD) with systemic inflammation, cytopenias, and life-threatening multiple organ dysfunction resulting from a cytokine storm often driven by interleukin 6 (IL-6). 30487129 2018
CUI: C0919747
Disease: Cytokine storm
Cytokine storm 		0.090 Biomarker disease BEFREE Human herpesvirus-8 (HHV-8)-negative, idiopathic multicentric Castleman disease (iMCD) is a rare and life-threatening disorder involving systemic inflammatory symptoms, polyclonal lymphoproliferation, cytopenias, and multiple organ system dysfunction caused by a cytokine storm often including interleukin-6. iMCD accounts for one third to one half of all cases of MCD and can occur in individuals of any age. 28087540 2017
CUI: C0919747
Disease: Cytokine storm
Cytokine storm 		0.090 Biomarker disease BEFREE PVR is associated with a cytokine storm involving common proinflammatory molecules like IL6, but little is known about the source and downstream signaling of IL6 and the consequences for the retina. 28645275 2017
CUI: C0919747
Disease: Cytokine storm
Cytokine storm 		0.090 Biomarker disease BEFREE Multicentric CD (MCD) involves multiple regions of enlarged lymph nodes, constitutional symptoms, and organ dysfunction due to a cytokine storm often including interleukin 6. 28135567 2017
CUI: C0919747
Disease: Cytokine storm
Cytokine storm 		0.090 Biomarker disease BEFREE IL-6 mRNA correlated with hypercytokinemia and recovery from hypercytokinemia (sensitivity 80.9%) and was a significant biomarker in predicting the onset of severe inflammatory diseases. 20969744 2010
CUI: C0919747
Disease: Cytokine storm
Cytokine storm 		0.090 GeneticVariation disease BEFREE Serum samples after cell infusion showed marked increases in interferon-gamma (IFN-gamma), granulocyte macrophage-colony stimulating factor (GM-CSF), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and IL-10, consistent with a cytokine storm. 20179677 2010
CUI: C0919747
Disease: Cytokine storm
Cytokine storm 		0.090 AlteredExpression disease BEFREE These pathogenic T cells initiated a cytokine storm characterized by high levels of tumor necrosis factor (TNF) and interleukin 6 (IL-6), and depletion of T cells or blockade of these inflammatory cytokines prevented the lethal disease. 20921283 2010