|
Lymphopenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Interleukin-7 (IL7) plays a nonredundant role in T cell survival and homeostasis, which is illustrated in the severe T cell lymphopenia of IL7-deficient mice, or demonstrated in animals or humans that lack expression of either the IL7Rα or γ <sub>c</sub> chain, the two subunits that constitute the functional IL7 receptor.
|
31137085 |
2019 |
|
Lymphopenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
While IL-7 deficiency results in lymphopenia, overexpression of IL-7 can cause neoplasia in experimental models.
|
30373315 |
2018 |
|
Lymphopenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Primary aims were to determine the safety of CYT107 in sepsis and its ability to reverse lymphopenia.
|
29515037 |
2018 |
|
Lymphopenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Taken together, we demonstrated different perioperative dynamics of interleukin-7, which may contribute to favourable outcomes following robotic colorectal surgery including lower incidence of surgical site infections, milder surgery-induced lymphopenia, and beneficial interferon-γ dynamics.
|
29904108 |
2018 |
|
Lymphopenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Conversely, increased IL-7 and IL-15 can expand memory T cells, including pathogenic tissue-resident memory T cells, as seen in lymphopenia and certain chronic-inflammatory disorders and malignancies.
|
29664568 |
2018 |
|
Lymphopenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, off-target inhibitory effects of IM on IL-7 and STAT5-p explain how T cell lymphopenia occurs in patients treated with IM.
|
28387753 |
2017 |
|
Lymphopenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
JC virus granule cell neuronopathy in the setting of chronic lymphopenia treated with recombinant interleukin-7.
|
27421731 |
2017 |
|
Lymphopenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Whether IL-7 and IL-15 are insufficient in patients with severe lymphopenia during severe sepsis warrants further investigations.
|
25692255 |
2015 |
|
Lymphopenia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Elevated serum interleukin 7 (IL-7) levels are observed in lymphopenic conditions, including idiopathic CD4 lymphopenia (ICL), which is characterized by CD4 lymphopenia in the absence of human immunodeficiency virus infection or other known immunodeficiency.
|
22454463 |
2012 |
|
Lymphopenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The aberrant T-cell expansions associated with the pathogenesis of CIN result in increased proliferation/apoptosis and possibly exhaustion of peripheral blood T cells which, in association with the inadequate compensatory thymic export of new TREC expressing T cells partially because of IL-7 deficiency, may contribute to lymphopenia in CIN.
|
22092365 |
2012 |
|
Lymphopenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Elevated IL-7 availability does not account for T cell proliferation in moderate lymphopenia.
|
21239710 |
2011 |
|
Lymphopenia
|
0.400 |
Biomarker
|
disease |
CTD_human |
An IL-7 splicing-defect lymphopenia mouse model revealed by genome-wide mutagenesis.
|
17151827 |
2007 |
|
Lymphopenia
|
0.400 |
Biomarker
|
disease |
LHGDN |
In addition, IL-7 plays a major role in the expansion of mature T-cells that occurs during lymphopenia and therapeutic IL-7 can enhance both quantitative and functional immune recovery following T-cell depletion.
|
16923550 |
2006 |
|
Lymphopenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
IL-7 deficiency has now been found in patients with rheumatoid arthritis, a finding that relates not only to the T-lymphocyte status in this disease but also to the ability of patients with rheumatoid arthritis to recover from therapy-induced lymphopenia.
|
15642153 |
2005 |
|
Lymphopenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Although there is increasing interest in the use of IL-7 for the treatment of lymphopenia caused by the HIV type 1, evidence that IL-7 may accelerate HIV replication has raised concerns regarding its use in this setting.
|
12847229 |
2003 |