Multiple Sclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In summary, our findings indicate an augmented type-17 differentiation of MAIT cells in MS patients associated with their IL-7 receptor surface expression, implicating a proinflammatory role of these unconventional T cells in MS immunopathology.
|
29298833 |
2018 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Combination of IL-7 and CXCL10 indicated risk for a specific MS clinical form, where IL-7<141 and CXCL10<570pg/ml were associated with the highest risk for PP-MS (OR=22, p=0.01).
|
28578025 |
2017 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
There was a statistically significant difference in the genotypes of IL-7 rs2887502 between MS and NMO patients (P = 0.014).
|
26608987 |
2015 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
IL7 is fundamental to development of IL17 producing cells and plays a role in maturation of auto-reactive T-cells, it is also associated with autoimmune disorders including multiple sclerosis and type-1 diabetes.
|
25933188 |
2015 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The T-allele in the single nucleotide polymorphism rs6897932 in the gene encoding the IL-7 receptor α (IL7RA) is associated with reduced risk of autoimmune diseases including multiple sclerosis and also affects the course of HIV infection.
|
25421942 |
2015 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The IL-7/IL-7R signaling axis participates in cell survival, and perturbation of this pathway has been associated with enhanced susceptibility to MS. A link between IL-23-driven pathogenic T cells and IL-7/IL-7R signaling has previously been proposed, but has not been formally addressed.
|
26223651 |
2015 |
Multiple Sclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Increased expression of IL-7 in the central nervous system as well as in peripheral immune cells is associated with multiple sclerosis and experimental allergic encephalomyelitis.
|
24224652 |
2014 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Former studies demonstrated the single nucleotide polymorphism (SNP) rs6897932 C/T in the IL-7 receptor (IL-7R) gene was associated with susceptibility to autoimmune diseases, including multiple sclerosis and type I diabetes.
|
24242875 |
2014 |
Multiple Sclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
IL-7 stimulation had a differential effect on both mRNA and protein expression of granzyme A and granzyme B between MS and HC.
|
22262655 |
2012 |
Multiple Sclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
IL-7 levels were significantly decreased in 40 MS patients compared with 40 HCs.
|
22914435 |
2012 |
Multiple Sclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We found reduced IL-7Rα expression on conventional T cells and upregulated IL-7 plasma levels together with reduction of RTE-Treg frequencies and Treg function in MS, without clear genetic influence.
|
21287555 |
2011 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our findings suggest that IL-7Ralpha polymorphisms can influence T cell development and homeostasis, and thereby contribute to the altered immune regulation associated with disease development in patients with MS.
|
20072142 |
2010 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
We measured the relative distribution of IL-7 and IL-7R spliced mRNA from patients with MS and healthy individuals and observed extensive alternative splicing of both genes with marked differences in proportional transcript expression levels.
|
20226540 |
2010 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genetic variation in the IL7RA/IL7 pathway increases multiple sclerosis susceptibility.
|
20112030 |
2010 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Common genetic variants of IL-7 receptor alpha (IL-7Ralpha) have recently been shown to affect susceptibility to multiple sclerosis (MS) and type 1 diabetes, and survival following bone marrow transplantation.
|
20097866 |
2010 |
Multiple Sclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We demonstrated that angiocidin and interleukin-7 (IL-7) are over-expressed in brain lesions of MS patients.
|
18207252 |
2008 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Additional alleles of IL7 and IL2 have been identified as risk factors for MS with small effect.
|
18612409 |
2008 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We conclude that the IL7 gene is very unlikely to influence the genetic susceptibility to MS in this population.
|
17913246 |
2007 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
CTD_human |
Variation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosis.
|
17660816 |
2007 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
In addition, we report altered expression of the genes encoding IL7Ralpha and its ligand, IL7, in the cerebrospinal fluid compartment of individuals with multiple sclerosis.
|
17660816 |
2007 |