Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
IL-8 antagonist, CXCL8(3-72)K11R/G31P coupled with probiotic exhibit variably enhanced therapeutic potential in ameliorating ulcerative colitis.
|
29655167 |
2018 |
Ulcerative Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The concentrations of hsCRP, GM-CSF, IFN<i>γ</i>, IL12(p70), and RANTES were higher in UC patients with active than inactive disease whereas those of IL8 and TNF<i>α</i> were significantly lower.
|
30147719 |
2018 |
Ulcerative Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
In accordance with the characteristic histological signs of active disease, IL-8-expressing cells were diffusely distributed over the entire affected mucosa in patients with ulcerative colitis, whereas in patients with Crohn's disease, IL-8-expressing cells showed a focal distribution pattern.
|
8178948 |
1994 |
Ulcerative Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Proinflammatory IL-8, degree of histological inflammation, and granulocyte content were similar in UC and CD.
|
17200145 |
2007 |
Ulcerative Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
We then identified potential target genes of the significantly dysregulated miRNAs and genes in active UC vs. controls and found a highly significant inverse correlation between hsa-miR-200c-3p and IL8, an inflammatory marker, and between hsa-miR-200c-3p and CDH11, a gene related to intestinal epithelial barrier function.
|
25546151 |
2014 |
Ulcerative Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
WGCNA Reveals Key Roles of IL8 and MMP-9 in Progression of Involvement Area in Colon of Patients with Ulcerative Colitis.
|
30074183 |
2018 |
Ulcerative Colitis
|
0.400 |
Biomarker
|
disease |
CTD_human |
Increased activation of NF-kappaB and high levels of the expression of interleukin (IL)-1beta mRNA and IL-8 mRNA were detected in biopsy specimens from patients with ulcerative colitis.
|
15955209 |
2005 |
Ulcerative Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
We found that levels of inflammatory cytokines TNF-α, IL-1β, IL-6 and IL-8 as well as histological damage in colonic tissues showed that engineered Bifidobacterium effectively reduced dextran sulfate sodium(DSS)-induced ulcerative colitis, we also tested the MPO, verified the above conclusions.
|
29455070 |
2018 |
Ulcerative Colitis
|
0.400 |
Biomarker
|
disease |
CTD_human |
(1) The expression of IL-1beta mRNA and IL-8 mRNA was increased significantly in patients with UC, as compared with that in the control specimens (P < 0.05) and had a significant positive correlation with NF-kappaB DNA binding activity (r = 0.8363, P < 0.05; r = 0.6024, P < 0.05, respectively).
|
12133438 |
2002 |
Ulcerative Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The expressions of interleukin-8 (IL-8) and intercellular adhesion molecule-1 (ICAM-1) in the colonic mucosa tissue in mild patients with UC were assayed by immunohistochemistry and RT-PCR.
|
19083096 |
2009 |
Ulcerative Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
ELOCA enabled quantitation of multiple mRNAs in small mucosal biopsies from untreated patients with CIIBD and supported a role for IL-8 and iNOS in acute inflammation in both UC and CD.
|
9072008 |
1997 |
Ulcerative Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
IL-8 response of HT29 cells was greater with Crohn's disease (689 +/- 298 [mean +/- SD] pg IL-8/mL at 4 hours, n = 7) and colon cancer isolates (532 +/- 415 pg/mL, n = 14) than with ulcerative colitis (236 +/- 58 pg/mL, n = 6) or control isolates (236 +/- 100 pg/mL, n = 6, P < 0.0001).
|
17941093 |
2008 |
Ulcerative Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results suggest that IL-8 is a novel susceptibility gene to UC in Chinese UC patients, and furthermore, that IL-8 polymorphisms may be related to severe clinical subtype of UC.
|
19348790 |
2009 |
Ulcerative Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In L biopsies from patients with CD, higher expression levels were found for IL-4 (p=0.009) and IL-12p35 (p=0.0005), whereas in L biopsy samples from patients with UC higher expression levels were found for IL-8 (p=0.03), chemokines SCYA3 (p=0.05), SCYA4 (p=0.01) and glutathione S-transferase P1 (p=0.01).
|
23014361 |
2013 |
Ulcerative Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Importantly, IL-8 mRNA expression was higher in UC and UCCP patients homozygous for the OCTN1 1672T variant compared to the other genotypes.
|
21793125 |
2012 |
Ulcerative Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Relative quantitative reverse transcription-polymerase chain reaction was applied to explore the gene expressions of CXCL16, its receptor CXCR6, and interleukin 8, an inflammatory marker, in the colonic biopsies of children with active ulcerative colitis (n=19), children with ulcerative colitis in remission (n=9) and children with no inflammatory condition in colon (n=14).
|
24630488 |
2014 |
Ulcerative Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The DAI scores and the expression levels of IL-6, IL-8 and TNF-α significantly increased in the experimental UC mice compared with the control mice, while the expression levels of IgA and sIgA decreased (all P<0.01).
|
30783488 |
2019 |
Ulcerative Colitis
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
(1) The expression of IL-1beta mRNA and IL-8 mRNA was increased significantly in patients with UC, as compared with that in the control specimens (P < 0.05) and had a significant positive correlation with NF-kappaB DNA binding activity (r = 0.8363, P < 0.05; r = 0.6024, P < 0.05, respectively).
|
12133438 |
2002 |
Ulcerative Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Increased activation of NF-kappaB and high levels of the expression of interleukin (IL)-1beta mRNA and IL-8 mRNA were detected in biopsy specimens from patients with ulcerative colitis.
|
15955209 |
2005 |
Ulcerative Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
IL-8 mRNA was significantly higher in inflamed UC samples than in uninflamed samples.
|
12425554 |
2002 |
Ulcerative Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In our study, we wanted to examine the correlation between transcript levels of interleukin 8 (CXCL8), interferon gamma inducible protein 10 (CXCL10), myeloid-related protein 14 (calgranulin B), macrophage inflammatory protein 2 alpha (CXCL2) with CAI and EAI in UC.
|
19203362 |
2009 |
Ulcerative Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Unexpectedly, IL-12, IL-1β and CD163-, but not CD163+, cells induced IL-8 expression in colonic CD4+T cells, which co-expressed IFN-γ and/or IL-17 in UC and not CD.
|
31206576 |
2020 |
Ulcerative Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Beneficial effects of transdermal nicotine in active UC may result from decrease of IL-8 expression at the transcriptional level.
|
10453373 |
1999 |
Ulcerative Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
It is found that the anti-UC activities are mainly focused on targeting inflammation or oxidative stress, which is associated with increasing the levels of anti-inflammatory cytokine (IL-4, IL-10, SOD), suppressing the levels of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, IL-8, IL-23, NF-κB, NO), reducing the activity of MPO, MDA, IFN-γ, and iNOS.
|
30797423 |
2019 |
Ulcerative Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The IL-8 mRNA expression ratios in UC (mean +/- SD, 1.03 +/- 0.52) and CD (0.90 +/- 0.38) patients were significantly higher than in IBS (0.52 +/- 0.17) (p < 0.01, p < 0.05, respectively).
|
11095335 |
2000 |