|
Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Astrocytoma cell secretion of IL-6 and IL-8 was unaffected by antigen exposure.
|
28234621 |
2017 |
|
Astrocytoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Thus, in the present study, the effects of GBP and PGB on SP‑induced activation were investigated in the human glioblastoma astrocytoma U373 MG cell line, which expresses high levels of functional high‑affinity NK1R, and produces interleukin (IL)‑6 and IL‑8 in response to SP.
|
28849160 |
2017 |
|
Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, we show here for the first time the paradoxical role of autophagy in mediating PCN-induced toxicity in 1321N1 astrocytoma and SH-SY5Y neuroblastoma cells and provide novel evidence that these actions may be mediated by effects on IL-8, PGE₂, and LTB₄ production.
|
23525265 |
2013 |
|
Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we have investigated whether IL-8 activation by PGE2 involves changes in DNA methylation and/or histone modifications in 46 astrocytoma specimens, two astrocytoma cell lines and normal astrocytic cells.
|
23051921 |
2012 |
|
Astrocytoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The long-term TMZ-treated astroglioma cells, but not the Hs683 oligodendroglioma cells, developed in vivo a certain level of resistance to TMZ, which correlated with the up- regulation of CXCL2, CXCL3 and CXCL8 expression in the U373 and T98G astroglioma cells.
|
21399866 |
2011 |
|
Astrocytoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Lipoxin A4 inhibits IL-1beta-induced IL-8 and ICAM-1 expression in 1321N1 human astrocytoma cells.
|
19357230 |
2009 |
|
Astrocytoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Mechanism of IFN-beta-mediated inhibition of IL-8 gene expression in astroglioma cells.
|
16818736 |
2006 |
|
Astrocytoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We have previously shown that Fas ligation induces expression of chemokines such as interleukin-8 by human astrogliomas, which may partially explain the in vivo angiogenic property of FasL.
|
14615040 |
2003 |
|
Astrocytoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Tumor necrosis factor-related apoptosis-inducing ligand induces caspase-dependent interleukin-8 expression and apoptosis in human astroglioma cells.
|
11784850 |
2002 |
|
Astrocytoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Previously, we have reported that Fas ligation induces selective expression of chemokines (IL-8 and MCP-1) in human astroglioma cells in vitro.
|
11949822 |
2002 |
|
Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Specifically, we have shown that primary human astrocytes and human astroglioma cell lines produce the CXC chemokines IFN-gamma-inducible protein-10 and IL-8 and the CC chemokines monocyte chemoattractant protein-1 and RANTES in response to stimuli such as TNF-alpha, IL-1beta, and IFN-gamma.
|
11160334 |
2001 |
|
Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present study shows that the synthetic glucocorticoid, dexamethasone, inhibits the induction of the proinflammatory cytokine IL-8 and the adhesion molecules VCAM-1 and ICAM-1 in human 1321N1 astrocytoma and SK.N.SH neuroblastoma cells.
|
10438951 |
1999 |
|
Astrocytoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results support a model where IL-8 expression is initiated early in astrocytoma development through induction by inflammatory stimuli and later in tumor progression increases due to reduced microenvironmental oxygen pressure.
|
9334359 |
1997 |
|
Astrocytoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Redox regulation of lipopolysaccharide (LPS)-induced interleukin-8 (IL-8) gene expression mediated by NF kappa B and AP-1 in human astrocytoma U373 cells.
|
9125224 |
1997 |
|
Astrocytoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IL-8 activity was produced constitutively in all astrocytomas and increased markedly upon stimulation with IL-1 beta or TNF alpha, in both a time- and dose-dependent fashion.
|
1407609 |
1992 |
|
Astrocytoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In particular, an astrocytoma cell line U373MG subclone responded markedly to IL-1 with high expression levels of IL-8 and MCAF mRNA as well as IL-6 mRNA.
|
1937574 |
1991 |