|
Psoriasis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The chemokine IL-8 was also over-expressed in psoriasis (P = 0·03) while IL-12, IL-17, IL-23, tumour necrosis factor-α and interferon-γ were only slightly more expressed in psoriasis than in normal skin, without reaching statistical significance.
|
31509228 |
2019 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Immunochemistry of EIP revealed features that overlapped contemporarily with psoriasis (cytokeratin 17 (CK17), Ki67, interleukin (IL)-8, IL-17, IL-23) and with ACD (CD1a, major histocompatibility complex (MHC) class I, MHC class II, epidermal T-cell subsets).
|
28853491 |
2018 |
|
Psoriasis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IL-8 levels in ILB correlated with local PASI scores and therefore reversed to those in CB after attenuation of psoriasis with treatment.
|
29366526 |
2018 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
At each step of the psoriasis molecular pathway, different inflammatory cytokines and angiogenic growth factors are involved such as hypoxia inducible factor-1 α (HIF-1 α), vascular endothelial growth factor (VEGF), matrix metalo proteinases (MMPs), basic fibroblast growth factor (bFGF), Angiopoitin-2, interleukin-8 (IL-8), IL-17, and IL-2.
|
28110689 |
2017 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
One of the consequences of this imbalance may be the increased induction of IL-8 that we found higher in acne, HS, and ACD respect to psoriasis.
|
28852851 |
2017 |
|
Psoriasis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
UVB irradiation inhibits IL-17A/TNF-α-induced IL-6, IL-8, and CXCL-1 production in HDFs by decreasing the expression of IL-17RA and IL-17RC on fibroblasts through TGF-β1/Smad3 signaling pathway, which reveals a new mechanism of the therapeutic action of UVB on psoriasis.
|
28217129 |
2017 |
|
Psoriasis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The chemokine CXCL8 was highly expressed in psoriasis, AD and allergic contact dermatitis, but not in irritant contact dermatitis.
|
19818069 |
2010 |
|
Psoriasis
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Because IL-8 is involved in many skin diseases such as psoriasis, we investigated the production of IL-8 in normal human epidermal keratinocytes (NHEKs) stimulated by IL-17F, tumor necrosis factor-alpha (TNF-alpha), IL-17A, and control using real-time PCR and ELISA.
|
18830271 |
2009 |
|
Psoriasis
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Interleukin 6 and 8 levels in plasma and fibroblast cultures in psoriasis.
|
16864908 |
2006 |
|
Psoriasis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
(4) The relevance of our findings to human disease was suggested by a TTA-mediated downregulation of serum levels of soluble VCAM-1 and IL-8 in psoriasis patients.
|
15920037 |
2005 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, HAT might promote PAR-2-mediated IL-8 production to accumulate inflammatory cells in the epidermal layer of psoriasis.
|
15102084 |
2004 |
|
Psoriasis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
As compared to normal skin (n = 7), there was an increased expression of TNF-alpha, IL-12p40, and IL-8, a decreased expression of TGF-beta1, and a lack of IL-10, similar to the findings in active psoriasis (n = 8).
|
15186319 |
2004 |
|
Psoriasis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression of innate immune response genes, human beta defensin (HBD)-2, IL-8, and inducible NO synthetase (iNOS) was found to be decreased in AD, as compared with psoriasis, skin (HBD-2, p = 0.00021; IL-8, p = 0.044; iNOS, p = 0.016).
|
12960356 |
2003 |
|
Psoriasis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IP-10 and IL-8 were consistently upregulated in the epidermis of patients with psoriasis but not in lesions of patients with AD.
|
11344355 |
2001 |
|
Psoriasis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Response of psoriasis to interleukin-10 is associated with suppression of cutaneous type 1 inflammation, downregulation of the epidermal interleukin-8/CXCR2 pathway and normalization of keratinocyte maturation.
|
11180010 |
2001 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, these data stress that, as previously described for interleukin-8, ET-1 may be involved in inflammatory processes associated with psoriasis.
|
9498021 |
1998 |
|
Psoriasis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Interleukin-8 (IL-8) may be important in psoriasis as it is expressed in the stratum granulosum, attracts polymorphonuclear cells, and stimulates angiogenesis and keratinocyte mitogenesis.
|
8823370 |
1996 |
|
Psoriasis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Differential expression of GRO-alpha and IL-8 mRNA in psoriasis: a model for neutrophil migration and accumulation in vivo.
|
8875965 |
1996 |
|
Psoriasis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IL-8/IL-8 receptor expression in psoriasis and the response to systemic tacrolimus (FK506) therapy.
|
7531627 |
1995 |
|
Psoriasis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our data suggest that in psoriatic skin, elevated IL-8 levels and markedly increased IL-8R expression may act in concert to induce the cardinal signs of psoriasis--epidermal hyperproliferation and leukocyte infiltration.
|
7691948 |
1993 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cellular localization of interleukin-8 and its inducer, tumor necrosis factor-alpha in psoriasis.
|
1702929 |
1991 |
|
Psoriasis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this case, local pharmacologic down-regulation of NAP-1/IL-8 activity could be a promising therapeutic strategy in PS.
|
1711550 |
1991 |