Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Respiratory Syncytial Virus Infections
0.100 AlteredExpression group BEFREE Additionally, ectopic expression of MEG3 reduced the expression level of TLR4, subsequently suppressing the mRNA expression levels of TNFα and IL‑8, indicating the protective role of MEG3 in the process of RSV infection. 29257348 2018
Respiratory Syncytial Virus Infections
0.100 Biomarker group BEFREE Haemophilus is overrepresented in the nasopharynx of infants hospitalized with RSV infection and associated with increased viral load and enhanced mucosal CXCL8 responses. 29325581 2018
Respiratory Syncytial Virus Infections
0.100 Biomarker group BEFREE There is an initial strong neutrophil response to RSV infection in humans, which is positively correlated with disease severity and mediated by interleukin-8 (IL-8). 28179378 2017
Respiratory Syncytial Virus Infections
0.100 AlteredExpression group BEFREE Decapping protein 1 phosphorylation modulates IL-8 expression during respiratory syncytial virus infection. 25796077 2015
Respiratory Syncytial Virus Infections
0.100 Biomarker group BEFREE Respiratory syncytial virus infection modulates interleukin‑8 production in respiratory epithelial cells through a transcription factor‑activator protein‑1 signaling pathway. 24968899 2014
Respiratory Syncytial Virus Infections
0.100 AlteredExpression group BEFREE Real-time, quantitative RT-PCR demonstrated significant increases in IL-8 gene expression following RSV infection when compared to controls. 15867636 2005
Respiratory Syncytial Virus Infections
0.100 Biomarker group BEFREE The association between elevated levels of nitric oxide (NO) and IL-8 in acute lung injury associated with sepsis, acute respiratory distress syndrome, respiratory syncytial virus infection in infants, and other inflammatory diseases suggested that NO may play important roles in the control of IL-8 gene expression in the lung. 15169673 2004
Respiratory Syncytial Virus Infections
0.100 Biomarker group BEFREE The purpose of this study was to investigate the vectorial release of interleukin (IL-8) and Released on Activation, Normal T-cell Expressed and Secreted (RANTES) by polarized, well-differentiated respiratory epithelial cells after RSV infection. 14967603 2004
Respiratory Syncytial Virus Infections
0.100 AlteredExpression group BEFREE Respiratory syncytial virus (RSV) infection of airway epithelial cells stimulates the expression and secretion of a variety of cytokines including the chemotactic cytokines interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1), and RANTES (regulated upon activation, normal T cell expressed and secreted). 11922866 2002
Respiratory Syncytial Virus Infections
0.100 GeneticVariation group BEFREE Disease severity following RSV infection appears to be determined by a genetic factor close to the IL-8 gene. 11083887 2000
Respiratory Syncytial Virus Infections
0.100 AlteredExpression group BEFREE Transcriptional activation of the interleukin-8 gene by respiratory syncytial virus infection in alveolar epithelial cells: nuclear translocation of the RelA transcription factor as a mechanism producing airway mucosal inflammation. 8971006 1996
Respiratory Syncytial Virus Infections
0.100 Biomarker group BEFREE To further characterize the mechanisms by which RSV infection triggers release of IL-8, we first exposed cultured A549 cells to RSV, and measured IL-8 release via enzyme-linked immunosorbent assays (ELISA), and IL-8 messenger RNA (mRNA) induction via Northern blot analysis. 7626291 1995
Respiratory Syncytial Virus Infections
0.100 Biomarker group BEFREE We have investigated if RSV infection of AM results in the production of cytokines TNF, IL-6, and IL-8, all of which may modulate inflammatory and immune responses to the virus, as well as may directly protect respiratory epithelial cells against spread of infection. 1753101 1991