Periodontitis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The overall analyses verified that the IL-10 rs1800872 polymorphism was significantly associated with an increased risk of periodontitis in the allelic model, homozygote model, dominant model, and recessive model (A vs C: OR = 1.28, 95%CI = 1.11-1.49, P = .00, I = 56.87%; AA vs CC: OR = 2.06, 95%CI = 1.32-3.23, P = .00, I = 73.3%; AA + AC vs CC: OR = 1.42, 95%CI = 1.03-1.96, P = .03, I = 76.2%; AA vs AC + CC: OR = 1.78, 95%CI = 1.26-2.56, P = .00, I = 76.7%).
|
31577700 |
2019 |
Periodontitis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Association of interleukin-10-1082 (-1087) A > G polymorphisms and periodontitis risk: An updated meta-analysis based on 26 case-control studies.
|
31222730 |
2019 |
Periodontitis
|
0.300 |
Biomarker
|
disease |
BEFREE |
In the chronic migraine group, patients with periodontitis had greater levels of serum CGRP (19.7 ± 6.5 versus 15.3 ± 6.2 pg/mL, P < 0.0001) and IL-6 (15.1 ± 9.2 versus 9.6 ± 6.3 pg/mL, P < 0.0001) while non-significant differences were observed with IL-10 (2.0 ± 1.0 versus 2.8 ± 1.5 pg/mL, P = 0.675) concentrations than those without periodontitis.
|
31070784 |
2019 |
Periodontitis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
However, the frequency of GG genotype in IL-10 -1082 (G/A) polymorphic region was higher in normal subjects and was associated with the decreased risk of periodontitis under recessive model [OR = 2.89, 95% CI (0.99-8.43), p = 0.039].
|
31055876 |
2019 |
Periodontitis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The studies reviewed support that the IL-10 rs1800871 and rs1800872 polymorphisms may represent a potential genetic biomarker for periodontitis risk in Latin American populations.
|
30343215 |
2019 |
Periodontitis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Additionally, we found that B10 cell transfer into the experimental periodontitis ones resulted in increased IL-10 (P < 0.05), but decreased IL-17 (P < 0.05) and receptor activator for nuclear factor κB ligand (RANKL) (P < 0.05) gene and protein expression in local lesions.
|
31701299 |
2019 |
Periodontitis
|
0.300 |
Biomarker
|
disease |
BEFREE |
The blockage of androgen receptor significantly increased radiographic bone loss and tissue levels of IL-1α (P <0.05), IL-1β (P <0.001) and IL-10 (P <0.01) compared with the periodontitis group.
|
31389012 |
2019 |
Periodontitis
|
0.300 |
Biomarker
|
disease |
BEFREE |
We show herein that, ASA-BMMSCs treatment reduced inflammatory infiltration and alveolar bone loss in periodontitis rats, reflected by immunohistochemistry staining of OPG/RANK-L and Micro-CT. Levels of TNF-α and IL-17 decreased while IL-10 increased after the treatment of ASA-BMMSCs in periodontitis rats.
|
29195233 |
2018 |
Periodontitis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Interleukin-10 polymorphisms affect the key periodontal pathogens in Chinese periodontitis patients.
|
29899423 |
2018 |
Periodontitis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Contribution of Interleukin-10-592 (-590, -597) C>A Polymorphisms to Periodontitis Susceptibility: An Updated Meta-Analysis Based on 18 Case-Control Studies.
|
30327689 |
2018 |
Periodontitis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
For individual studies, odds ratio (OR) and its 95%confidence interval (CI) were calculated to assess the strength of association between IL10 polymorphisms (- 1082 A > G, -819C > T, - 592 A > C) and the risk of periodontitis.
|
30348144 |
2018 |
Periodontitis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Protein analysis demonstrated higher levels of the TGFβ1 and IL10 cytokines in periodontitis tissues and in B-cell and plasma cell predominant gingival tissues than in healthy/gingivitis tissues and T-cell predominant gingival tissues.
|
29633265 |
2018 |
Periodontitis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Ligature-induced periodontitis exhibited similar patterns of bone loss and inflammatory cytokine profile in both groups of mice, except that the level of Il10 was elevated (P = .0114) whereas the Rankl/Opg ratio was not elevated (P = .9755) in Tlr2-KO mice compared with control mice.
|
28872184 |
2018 |
Periodontitis
|
0.300 |
Therapeutic
|
disease |
RGD |
Physical Exercise Improves Glycemic and Inflammatory Profile and Attenuates Progression of Periodontitis in Diabetic Rats (HFD/STZ).
|
30405072 |
2018 |
Periodontitis
|
0.300 |
Biomarker
|
disease |
BEFREE |
More IL-1β, IL-6, IL-17A, and RANKL, and less IL-10 and TGF-β are also detected in the gingiva and CLNs from animals with periodontitis than the one from healthy animals.
|
29951876 |
2018 |
Periodontitis
|
0.300 |
Biomarker
|
disease |
BEFREE |
The percentages of CD25<sup>+</sup>Foxp3<sup>+</sup> Treg significantly increased in the peripheral blood, which was consistent with gingival tissues study that Treg cells related transcription factor Foxp3 mRNA and cytokines IL-10 and TGF-β increased in the course of periodontitis.
|
28392902 |
2017 |
Periodontitis
|
0.300 |
Biomarker
|
disease |
BEFREE |
This study was conducted to determine the effect of local B10 cell induction on periodontal inflammation and bone loss in ligature-induced experimental periodontitis in vivo Purified spleen B cells from C57BL/6J mice (8 to 10 weeks old) were cultured with CD40 ligand (CD40L) and the Toll-like receptor 9 (TLR9) agonist cytidine-phosphate-guanosine oligodeoxynucleotide (CpG) to determine effective IL-10 induction in vitro Silk ligatures (size 7-0) were tied around the mouse maxillary second molars on day 0, followed by the injection of CD40L and CpG into the palatal gingiva on days 3, 6, and 9.
|
27795360 |
2017 |
Periodontitis
|
0.300 |
Biomarker
|
disease |
BEFREE |
The mRNA and protein levels of IL-10, IL-1β, and RANKL, as well as mRNA levels of TNF-α, were positively correlated with the number of IL-10 producing CD19<sup>+</sup> B cells, which highlights the importance of these factors in the development and progression of periodontitis.
|
28985543 |
2017 |
Periodontitis
|
0.300 |
Biomarker
|
disease |
RGD |
Carvedilol decrease IL-1β and TNF-α, inhibits MMP-2, MMP-9, COX-2, and RANKL expression, and up-regulates OPG in a rat model of periodontitis.
|
23843954 |
2013 |
Periodontitis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Association of the IL-10 polymorphisms and periodontitis: a meta-analysis.
|
22763734 |
2012 |
Periodontitis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Interleukin-10 gene promoter polymorphisms have been associated with interleukin-10 decreased production, thereby playing a role in the pathogenesis of periodontitis.
|
22077544 |
2012 |
Periodontitis
|
0.300 |
Biomarker
|
disease |
BEFREE |
When comparing genotype/allele frequencies in periodontitis versus healthy and periodontitis versus gingivitis scenarios, the number of positive associations (2-4) and the degree of association (p and odds ratio values) were significantly increased by the new approach proposed (periodontitis versus gingivitis), suggesting the association of IL1B-3954, TNFA-308, IL10-592 and TLR4-299 with periodontitis risk.
|
22324464 |
2012 |
Periodontitis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
We found that there was no association between IL-10 -1082 gene polymorphism and periodontitis risk (either CP or AgP), even when we separately investigated sub-group analysis among Caucasians.
|
22698805 |
2012 |
Periodontitis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The transcription factor Sp1 was present in large amounts in periodontitis lesions, and the local expression of Sp1 was related to the -1087 IL-10 SNP.
|
21309719 |
2011 |
Periodontitis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Interleukin-10 (-592 C/A) and interleukin-12B (+16974 A/C) gene polymorphisms and the interleukin-10 ATA haplotype are associated with periodontitis in a Taiwanese population.
|
19210338 |
2009 |