Strikingly, the numbers of IL-10<sup>+</sup> CD68<sup>+</sup> macrophages and the percentage of IL-10<sup>+</sup> CD68<sup>+</sup> macrophages relative to the total number of macrophages were decreased in eosinophilic polyps, despite the upregulation of M2 macrophages in this type of polyp.
This was consistent with a decrease in gene expression of EMR1 in the colon tissue and polyp tissue as well as expression of select markers associated with M1 (IL-6) and M2 macrophages (IL-13, IL-10, TGFβ, CCL17) in the colon tissue ( P < 0.05).
Polyp iNKT cells were enriched for interleukin-10 (IL-10)- and IL-17-producing cells, showed a distinct phenotype being CD4<sup>+</sup>, NK1.1<sup>-</sup> CD44<sup>int</sup>, and PD-1<sup>lo</sup>, and they were negative for the NKT cell transcription factor promyelocytic leukemia zinc-finger.