Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
BEFREE |
The infarct volume, as well as serum levels of matrix metalloproteinase-9 (MMP-9) and interleukin-10 (IL-10), were measured one week after stroke.
|
31807255 |
2019 |
Cerebrovascular accident
|
0.300 |
AlteredExpression
|
group |
BEFREE |
<b>Results:</b> MCAo resulted in profound attenuation of immune activation, as anticipated. t-PA treatment not only worsened neurological deficit, but further reduced lymphocyte and monocyte counts in blood, enhanced plasma levels of both IL-10 and TNFα and decreased various conventional DC subsets in the spleen and cLN, consistent with enhanced immunosuppression and systemic inflammation after stroke.
|
30972077 |
2019 |
Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
BEFREE |
Altogether these data support BDNF- and IL-10-based mechanisms underlying the neuroprotective potential of SEC therapy for stroke, and further advance the concept of exploiting the pathological link between brain and spleen as therapeutic targets.
|
31415765 |
2019 |
Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
BEFREE |
We aimed to evaluate the predictive value of three inflammatory biomarkers (interleukin [IL]-9, IL-10, and interferon [IFN]-γ) for stroke and mortality in atrial fibrillation.
|
31813744 |
2019 |
Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
BEFREE |
We measured baseline IL-6, IL-8, and IL-10 in a case-cohort study of 557 participants with incident stroke over 5.4 years and 951 participants in a cohort sample.
|
31004072 |
2019 |
Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
BEFREE |
This work was designed to examine the effect of mouse recombinant resistin on mRNA expression of Tumor necrosis factor-α (TNF-α), Interleukin-1β (IL-1β), Interleukin-10 (IL-10), Transforming growth factor-β1 (TGF- β1), and Heat shock protein-70 (HSP-70) in mouse model of stroke.
|
30120034 |
2018 |
Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
BEFREE |
Subsequent studies identified interleukin-10 as a common regulatory cytokine among all five of the currently recognized Breg cell subsets, several of which can be found in the affected brain hemisphere after induction of experimental stroke in mice.
|
29313944 |
2018 |
Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
BEFREE |
Stroke triggers a robust and sustained shift in systemic immunity in patients, including specific lymphopenia, robust activation of <i>i</i>NKT cells, systemic production of IL-10, and a prolonged T<sub>H</sub>2-skewed immunity, all are potential contributors to severe immune suppression seen in patients after stroke.
|
28154551 |
2017 |
Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
BEFREE |
By comparing the serum levels of inflammatory biomarkers, it was observed that IL‑6 and B1R levels tended to decline whereas IL‑10 levels increased in stroke patients from <30 days to over 180 days.
|
28990089 |
2017 |
Cerebrovascular accident
|
0.300 |
GeneticVariation
|
group |
BEFREE |
Our findings indicate that IL-10 -1082G/A polymorphism may be used as a genetic marker for identifying individuals at increased risk of developing stroke.
|
26654671 |
2016 |
Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
RGD |
Moderate hypothermia inhibits brain inflammation and attenuates stroke-induced immunodepression in rats.
|
23981596 |
2014 |
Cerebrovascular accident
|
0.300 |
Therapeutic
|
group |
RGD |
Splenectomy protects experimental rats from cerebral damage after stroke due to anti-inflammatory effects.
|
23786953 |
2013 |
Cerebrovascular accident
|
0.300 |
GeneticVariation
|
group |
BEFREE |
We observed a significantly higher frequency of IL-10 1082 AA genotype in stroke patients with a significant risk trend.
|
22425140 |
2012 |
Cerebrovascular accident
|
0.300 |
GeneticVariation
|
group |
BEFREE |
IL10-1082 GG genotype was found to significantly predict early stroke progression [OR (95% CI) = 3.72 (1.28-10.76)] and functional outcome by months 1 and 3 [OR (95% CI) = 5.03 (1.15-21.94) and 5.84 (1.07-31.85), respectively], after further corrections for stroke severity and TOAST categories.
|
20880001 |
2011 |
Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
BEFREE |
IL-20 is a proinflammatory cytokine of the IL-10 family that is involved in psoriasis, rheumatoid arthritis, atherosclerosis, and stroke.
|
21844205 |
2011 |
Cerebrovascular accident
|
0.300 |
GeneticVariation
|
group |
BEFREE |
Moreover, hypertensive and diabetic individuals bearing A allele of IL-10 gene in high frequency were found to be more predisposed to stroke.
|
21030268 |
2010 |
Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
BEFREE |
Furthermore, intramyocardial injection of wild-type BM-MNCs led to a significant increase in stroke volume (SV) and rate of the development of pressure over time (+dP/dt) compared to hearts injected with either diluent or IL-10 knock-out BM-MNCs.
|
18566343 |
2008 |
Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
BEFREE |
The IL-10-secreting monocytes did not change over the course of stroke.
|
11720009 |
2001 |