Endotoxemia
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Our data showed that an early single intravenous injection of BMDMCs in animals submitted to the murine model of endotoxemia led to the improvement of survival rate; BMDMCs persistency in lung, liver, and spleen after 24 h; decreased necrosis and apoptosis of mononuclear cells; lower TNF-α, but increased IL-10 concentration in plasma; and tissue-specific cytokine profile.
|
29621118 |
2019 |
Endotoxemia
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
In LPS-stimulated RAW264.7 cells and in peritoneal macrophages from endotoxemic mice, NC and TOP1 inhibitors significantly enhanced the activation of Akt, a critical signal transducer for IL-10 production, and inhibition of Akt prevented these compounds from enhancing IL-10 production and ameliorating endotoxemia.
|
31415918 |
2019 |
Endotoxemia
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Pro-Inflammatory Th1 and Th17 Cells Are Suppressed During Human Experimental Endotoxemia Whereas Anti-Inflammatory IL-10 Producing T-Cells Are Unaffected.
|
29868038 |
2018 |
Endotoxemia
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
Further, Adrb2<sup>-</sup><sup>/</sup><sup>-</sup> animals rapidly succumbed to endotoxemia in response to a sub-lethal LPS challenge and exhibited elevated serum levels of TNF-α and reduced IL-10.
|
30195028 |
2018 |
Endotoxemia
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
Using a mouse model of endotoxemia, we provide evidence to show that hepatocyte growth factor (HGF) enhances HO-1 expression in macrophages, thereby up-regulating IL-10 and down-regulating IL-6 productions.
|
19578789 |
2009 |
Endotoxemia
|
0.300 |
Biomarker
|
phenotype |
RGD |
Glutamine decreases inflammation in infant rat endotoxemia.
|
19302852 |
2009 |
Endotoxemia
|
0.300 |
GeneticVariation
|
phenotype |
BEFREE |
The influence of tumor necrosis factor-alpha and interleukin-10 gene promoter polymorphism on the inflammatory response in experimental human endotoxemia.
|
11588702 |
2001 |
Endotoxemia
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Specifically, we review the role of IL-10 in human endotoxemia/sepsis and in HIV infection, conditions for which preliminary phase I trials have recently been undertaken.
|
11197608 |
2000 |
Endotoxemia
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
IL-10 attenuates LPS-induced production of CC chemokines in human endotoxemia, whereby in vitro experiments suggest that, in the case of MIP-1alpha and MIP-1beta release, this effect is independent from an inhibitory effect on TNF production.
|
10669345 |
2000 |
Endotoxemia
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Interleukin-10 (IL-10) protects animals from lethal endotoxemia.
|
9872676 |
1998 |
Endotoxemia
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
Adenoviral vector-mediated interleukin-10 expression in vivo: intramuscular gene transfer inhibits cytokine responses in endotoxemia.
|
9081704 |
1997 |
Endotoxemia
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Human tumor necrosis factor receptor (p55) and interleukin 10 gene transfer in the mouse reduces mortality to lethal endotoxemia and also attenuates local inflammatory responses.
|
7760015 |
1995 |