Adult Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here, we report that myeloid-deficient Becn1 (Becn1ΔM) mice developed neutrophilia, were hypersusceptible to LPS-induced septic shock, and had a high risk of developing spontaneous precursor B cell (pre-B cell) lymphoma with elevated expression of immunosuppressive molecules programmed death ligand 1 (PD-L1) and IL-10.
|
31503548 |
2019 |
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
With limited sample size, gradient boosting can differentiate endophthalmitis from uveitis and lymphoma by IL-6 and IL-10 with high sensitivity and specificity; however, a larger cohort is needed for further validation.
|
28157416 |
2017 |
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Synergy of interleukin 10 and toll-like receptor 9 signalling in B cell proliferation: Implications for lymphoma pathogenesis.
|
27668411 |
2017 |
Adult Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Interleukin-10 (IL10) overproduction (P = .0003) was found in patients developing lymphoma.
|
26463422 |
2016 |
Adult Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the meta-analysis suggests that the IL-10-1082A>G polymorphism is weakly associated with altered susceptibility to lymphoma.
|
25171480 |
2014 |
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results identify CXCL13 and IL-10 as potentially important biomarkers of CNS lymphoma that merit further evaluation and support incorporation of CXCL13 and IL-10 into diagnostic algorithms for the workup of focal brain lesions in which lymphoma is a consideration.
|
23570798 |
2013 |
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Even small numbers of adoptively transferred B10 cells dramatically suppressed CD20 mAb-mediated lymphoma depletion by inhibiting mAb-mediated monocyte activation and effector function through IL-10-dependent mechanisms.
|
22019587 |
2011 |
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Qualitative and quantitative expression of EBV Encoded RNAs (EBER1, EBER2) and anti-inflammatory cytokine (interleukin-10) in FFPE EBV positive lymphoma tissue samples were then analysed by using reverse transcriptase polymerase chain reaction (RT-PCR) and real time polymerase chain reaction (qRT-PCR), respectively.
|
21791113 |
2011 |
Adult Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Carriage of two copies of the 'low IL10' haplotype rs1800896_A/rs1800871_T/rs1800872_A was associated with decreased lymphoma risk that varied by number of copies (Ptrend = 0.02).
|
20299965 |
2010 |
Adult Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In addition, polymorphisms in the interleukin-10 (IL-10) and transforming growth factor-beta (TGF-beta) genes previously associated with lymphoma development were also typed.
|
20207982 |
2010 |
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interestingly, several B lymphoma cell lines were observed to secrete 400-1300 pg/ml IL-10 in vitro, and coculture of human macrophages with lymphoma conditioned medium increased significantly their phagocytic capacity.
|
19299742 |
2009 |
Adult Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Five hundred patients with aggressive NHL treated with CHOP/CHOEP were analyzed for IL-10 gene polymorphisms, including distal loci -7400InDel, -6752AT (rs6676671), and -6208CG (rs10494879) in comparison with proximal loci -3538AT (rs1800890), -1087AG (rs1800896), and -597AC (rs1800872) according to the incidence and outcome of the lymphoma.
|
18559596 |
2008 |
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interleukin-10 (IL-10) is one of the cytokines implicated in the pathogenesis of diffuse large B-cell lymphoma (DLBCL) in which it acts as auto/paracrine growth factor for lymphoma growth.
|
17408400 |
2007 |
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Gene polymorphisms in Toll-like receptors, interleukin-10, and interleukin-10 receptor alpha and lymphoma risk.
|
16971956 |
2006 |
Adult Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Thus, polymorphisms in the IL-10 gene promoter which are associated with a low IL-10 producing phenotype may influence susceptibility to aggressive forms of lymphoma or may contribute to the pathogenesis of this disease.
|
12688341 |
2003 |
Adult Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In an independent genetic analysis of single-nucleotide polymorphisms within the promoter region of the IL10 gene in 1157 MACS subjects, a high IL10-expressing genotype (-592 C/C) was overrepresented among lymphoma subjects (P = 0.009), even when controlling for race (P = 0.006).
|
14597210 |
2003 |
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results suggest that IL-10 and IL-13 contribute to the pathogenesis of PSS and might explain the B cell abnormalities and the development of lymphoma observed in this autoimmune disease.
|
8964596 |
1996 |
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These studies suggest that IL-6 and IL-10 are involved in the pathogenesis of AIDS-associated large cell and mixed immunophenotype lymphoma.
|
7584673 |
1995 |
Adult Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Since murine Ly1-positive peritoneal or lymphoma B cells strongly express IL-10, we examined malignant cells from patients with acute and chronic leukemias by reverse transcriptase polymerase chain reaction (RT-PCR) for the expression of IL-10 mRNA.
|
7694007 |
1993 |