IL11, interleukin 11, 3589

N. diseases: 244; N. variants: 3
Disease: Degenerative polyarthritis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.050 Biomarker disease BEFREE Ten of the likely effector genes, including TGFB1 (transforming growth factor beta 1), FGF18 (fibroblast growth factor 18), CTSK (cathepsin K), and IL11 (interleukin 11), have therapeutics approved or in clinical trials, with mechanisms of action supportive of evaluation for efficacy in osteoarthritis. 30664745 2019
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.050 AlteredExpression disease BEFREE IL-11 levels were elevated in RA synovial fluid (SF) compared to osteoarthritis (OA) SF and plasma from RA, OA and normal individuals (NLs). 29327326 2018
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.050 GeneticVariation disease BEFREE Meta-analysis of Icelandic and UK data sets identifies missense variants in SMO, IL11, COL11A1 and 13 more new loci associated with osteoarthritis. 30374069 2018
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.050 AlteredExpression disease BEFREE Zac1 regulates IL-11 expression in osteoarthritis. 30197757 2018
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.050 AlteredExpression disease BEFREE Osteoblasts and stromal cells isolated from femora in rheumatoid arthritis (RA) and osteoarthritis (OA) patients express IL-11, leukaemia inhibitory factor and oncostatin M. 10632674 2000