|
Primary biliary cirrhosis
|
0.140 |
GeneticVariation
|
disease |
BEFREE |
Variants originally associated with juvenile idiopathic arthritis (VTCN1 gene), sarcoidosis (ANXA11 gene), primary biliary cirrhosis (IL12RB2 gene) and celiac disease (LPP gene) were not associated with type 1 diabetes in our dataset.
|
23152861 |
2012 |
|
Primary biliary cirrhosis
|
0.140 |
Biomarker
|
disease |
BEFREE |
CONCLUSION: Our data show an increased sensitivity of PBC and pSS Treg cells to low dose IL-12 stimulation, providing ongoing support for the importance of the IL12-IL-12Rβ2-STAT4 pathway on Treg cells in disease pathogenesis and potentially treatment.
|
30119881 |
2018 |
|
Primary biliary cirrhosis
|
0.140 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of IL12RB2 May Affect the Natural History of Primary Biliary Cholangitis: A Single Centre Study.
|
28299343 |
2017 |
|
Primary biliary cirrhosis
|
0.140 |
GeneticVariation
|
disease |
BEFREE |
Our data show significant associations between primary biliary cirrhosis and common genetic variants at the HLA class II, IL12A, and IL12RB2 loci and suggest that the interleukin-12 immunoregulatory signaling axis is relevant to the pathophysiology of primary biliary cirrhosis.
|
19458352 |
2009 |
|
Rheumatoid Arthritis
|
0.110 |
AlteredExpression
|
disease |
BEFREE |
IL-35R subunits, gp130 and IL-27Rα, but not IL-12Rβ2, were expressed in B cells extracted from the synovium and periphery of patients with RA/OA.
|
29247146 |
2018 |
|
Lupus Erythematosus, Systemic
|
0.110 |
Biomarker
|
disease |
BEFREE |
The results supported the theory that IL12RB2 is associated with SLE in the Chinese population.
|
25720506 |
2015 |
|
Systemic Scleroderma
|
0.110 |
GeneticVariation
|
disease |
BEFREE |
Aiming to reveal the possible implication of the IL12RB2 gene in SSc, we conducted a follow-up study of this locus in different Caucasian cohorts.
|
22076442 |
2012 |
|
Behcet Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our findings not only confirmed the association of IL10/rs1800871 and IL23R-IL12RB2/rs924080 with BD but also identified 2 susceptibility single nucleotide polymorphisms in IL10 and IL23R-IL12RB2 (rs3024490 and rs12141431) with BD in Han Chinese.
|
27464962 |
2017 |
|
Behcet Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
We tested 14 single-nucleotide polymorphisms (SNPs) in 13 genomic loci (excluding the major histocompatibility complex [MHC], IL10, and IL23R-IL12RB2, which have already been associated with BD in Iranians) for allelic and genotypic associations with BD in 973 patients and 828 controls from Iran and performed meta-analyses of the significantly associated markers.
|
26097239 |
2015 |
|
Behcet Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
SNPs (rs924080 and rs11209032) of the IL23R-IL12RB2 region were found to be associated with BD in a Northern Chinese Han population.
|
27660093 |
2016 |
|
Behcet Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
An IL23R-IL12RB2 intergenic SNP rs1495965 was significantly associated with BD risk (OR (95% CI) = 1.5 (1.3, 1.7), P = 2.5 × 10<sup>-7</sup>) in the pooled meta-analysis of the discovery (1.4 (1.2, 1.7), P = 4.9 × 10<sup>-7</sup>) and replication (1.9 (1.3, 2.6), P = 6.0 × 10<sup>-4</sup>) phases.
|
29017598 |
2017 |
|
Behcet Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Six SNPs in IL23R-IL12RB2 were found to be associated with BD after Bonferroni correction for multiple testing, the most significant of which were rs17375018 (OR for G allele 1.51, 95% CI 1.27-1.78, P(unadj) = 1.93 × 10(-6) ), rs7517847 (OR for T allele 1.48, 95% CI 1.26-1.74, P(unadj) = 1.23 × 10(-6) ), and rs924080 (OR for T allele 1.29, 95% CI 1.20-1.39, P = 1.78 × 10(-5) ).
|
22378604 |
2012 |
|
Behcet Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease.
|
20622878 |
2010 |
|
Behcet Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although we were not able to formally replicate the association with IL10 and IL23R-IL12RB2, we do report that BD in Iran is strongly associated with HLA-B*51, MICA-A6, and the three HLA-linked SNPs (odds ratio (OR) = 3.38, P = 6.21 × 10(-14); OR = 2.08, P = 1.58 × 10(-13); and OR = 1.67-4.05, P = 1.45 × 10(-04) to 4.79 × 10(-34), respectively).
|
25940109 |
2015 |
|
Behcet Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genetic variations of IL-12B, IL-12Rβ1, IL-12Rβ2 in Behcet's disease and VKH syndrome.
|
24859272 |
2014 |
|
Behcet Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Two recent large genome-wide association study (GWAS) conducted in Turkey and Japan reported association between single nucleotide polymorphism (SNP) of interleukin (IL)-10 and IL-23R/IL-12RB2 genes and BD.
|
22197900 |
2012 |
|
Behcet Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci.
|
20622879 |
2010 |
|
Non-Small Cell Lung Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Compared with in benign pulmonary tissues, the expression levels of IL‑12Rβ2 and p38MAPK were not demonstrated to be significantly different in I+II pathological tumor‑node‑metastasis (pTNM) stage NSCLC tissues; however, reduced expression was detected in III+IV pTNM stage NSCLC tissues.
|
29956791 |
2018 |
|
Non-Small Cell Lung Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
In order to perform in vivo studies, the Calu6 NSCLC cell line was transfected with the IL-12RB2 containing plasmid (Calu6/beta2).
|
19582164 |
2009 |
|
Non-Small Cell Lung Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
In contrast to benign pulmonary, ERβ2 and IL-12Rβ2 were over-expressed in NSCLC (p = 0.000).
|
23677568 |
2013 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Interestingly, p40 was involved in the arrest of IL-12 receptor (IL-12R) IL-12Rβ1, but not IL-12Rβ2, in the membrane, and that p40 neutralization induced the internalization of IL-12Rβ1 via caveolin and caused cancer cell death via the IL-12-IFN-γ pathway.
|
29073075 |
2017 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
These studies, together with others performed in Il12rb2 knockout mice, have established the concept that the IL-12Rbeta2 gene is a gatekeeper from cancer.
|
19720917 |
2009 |
|
Malignant neoplasm of larynx
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The significant correlations between IL-12Rβ2 and IL-23R expression and TIL ratios were identified in LC tissues, particularly in well-differentiated LC.
|
30355949 |
2018 |
|
Malignant neoplasm of larynx
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Tumor cell differentiation is associated with TILs' expression of IL-12Rβ2, and an IL-12Rβ2<sup>+</sup> TIL ratio ≥35%) indicates favorable prognosis in LC.
|
29103744 |
2017 |
|
Leprosy
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest that polymorphisms present in the promoter region of IL12RB2 may not be associated with susceptibility to leprosy or its clinical forms.
|
24486579 |
2014 |