|
Behcet's uveitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Single-Nucleotide Polymorphisms in IL23R-IL12RB2 (rs1495965) Are Highly Prevalent in Patients with Behcet's Uveitis and Vary Between Populations.
|
29792538 |
2019 |
|
Myasthenia Gravis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Evidence for association of STAT4 and IL12RB2 variants with Myasthenia gravis susceptibility: What is the effect on gene expression in thymus?
|
29576322 |
2018 |
|
Primary Sjögren's syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
CONCLUSION: Our data show an increased sensitivity of PBC and pSS Treg cells to low dose IL-12 stimulation, providing ongoing support for the importance of the IL12-IL-12Rβ2-STAT4 pathway on Treg cells in disease pathogenesis and potentially treatment.
|
30119881 |
2018 |
|
Intrahepatic Cholangiocarcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
High expression of IL-35R (gp130 and IL-12Rβ2) was also observed in ICC cancer tissues, but only gp130 was an independent prognostic factor for OS and RFS and was indispensable in IL-35-mediated ICC clinical prognosis.
|
29446854 |
2018 |
|
IgE-mediated food allergy
|
0.010 |
Biomarker
|
disease |
BEFREE |
The biological relevance of the IEC-associated IL-12Rβ2 was assessed <i>in vivo</i> in a mouse model of food allergy characterized by allergy-associated diminished intestinal levels of IL-12 and in chimeric mice that lack the IL-12Rβ2 chain on IECs.
|
29896198 |
2018 |
|
Skin Abnormalities
|
0.010 |
Biomarker
|
group |
BEFREE |
In the pre-lesional group that shows no obvious skin abnormality on clinical observation, 30 dysregulated genes are nevertheless identified though the fold changes are much less than that of the lesional group, including CCL6, CCL8, CCL11, CCL17, CXCL13, CXCL14, CXCR3 and IL-12Rβ2.
|
26585782 |
2016 |
|
Takayasu Arteritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings suggest that the polymorphisms of IL12A, IL12B, IL12RB1, IL12RB2 and IL23R might make no contribution to the susceptibility of TA in the Chinese population.
|
26987707 |
2016 |
|
Malignant neoplasm of stomach
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Therefore heterozygous inactivating mutations in IL12RB1 and IL12RB2 are unlikely to be frequently involved in GC predisposition.
|
25467645 |
2015 |
|
Stomach Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Therefore heterozygous inactivating mutations in IL12RB1 and IL12RB2 are unlikely to be frequently involved in GC predisposition.
|
25467645 |
2015 |
|
Multiple Sclerosis, Relapsing-Remitting
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Higher expression of IL-12Rβ2 is associated with lower risk of relapse in relapsing-remitting multiple sclerosis patients on interferon-β1b therapy during 3-year follow-up.
|
26439963 |
2015 |
|
Allergic rhinitis (disorder)
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The association study of each polymorphism of the IL-12Rβ1 and IL-12Rβ2 gene and AR showed that a significantly increased prevalence of the homozygous rs438421 GG genotype and G allele appeared in the AR patients compared with healthy controls.
|
24997981 |
2015 |
|
Uveomeningoencephalitic Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Genetic variations of IL-12B, IL-12Rβ1, IL-12Rβ2 in Behcet's disease and VKH syndrome.
|
24859272 |
2014 |
|
Cervical Squamous Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We evaluated 76 tagSNPs from seven candidate genes (IL-10, IL-12A, IL-12B, IL-10RA, IL-10RB, IL-12RB1, and IL12RB2) in case-parent sets (n=43 cervical squamous cell carcinoma (SCC), n=96 cervical adenocarcinoma, n=53 vulvar SCC), additional cases (n=356 cervical SCC, n=406 cervical adenocarcinoma, and n=473 vulvar SCC) and population based controls (1,111).
|
23280621 |
2013 |
|
Cervical Adenocarcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We evaluated 76 tagSNPs from seven candidate genes (IL-10, IL-12A, IL-12B, IL-10RA, IL-10RB, IL-12RB1, and IL12RB2) in case-parent sets (n=43 cervical squamous cell carcinoma (SCC), n=96 cervical adenocarcinoma, n=53 vulvar SCC), additional cases (n=356 cervical SCC, n=406 cervical adenocarcinoma, and n=473 vulvar SCC) and population based controls (1,111).
|
23280621 |
2013 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
Biomarker
|
disease |
BEFREE |
By analyzing the relation between ERβ2, IL-12Rβ2 mRNA expression levels and clinical characteristics, it was revealed that ERβ2 and IL-12Rβ2 were significant correlated with regional lymph node metastasis, T stage and clinical stage (p = 0.000/0.000; 0.001/0.000; 0.031/0.003 respectively), and both protein expression levels were lower with TNM stage being higher.
|
23677568 |
2013 |
|
Progression of non-small cell lung cancer
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Estrogens and IL-12 play a pivotal role in the development and progression of non-small-cell lung cancer (NSCLC); at the same time, estrogen receptor β2 and (interleukin-12 receptor β2)IL-12Rβ2 are their important receptors, respectively.
|
23677568 |
2013 |
|
Celiac Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Variants originally associated with juvenile idiopathic arthritis (VTCN1 gene), sarcoidosis (ANXA11 gene), primary biliary cirrhosis (IL12RB2 gene) and celiac disease (LPP gene) were not associated with type 1 diabetes in our dataset.
|
23152861 |
2012 |
|
Crohn Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
We found strong evidence of CD-association for 195 genes, identifying novel susceptibility genes (e.g., ISX, SLCO6A1, TMEM183A) as well as confirming many previously identified susceptibility genes in CD GWAS (e.g., IL23R, NOD2, CYLD, NKX2-3, IL12RB2, ATG16L1).
|
23071489 |
2012 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.010 |
Biomarker
|
disease |
BEFREE |
Variants originally associated with juvenile idiopathic arthritis (VTCN1 gene), sarcoidosis (ANXA11 gene), primary biliary cirrhosis (IL12RB2 gene) and celiac disease (LPP gene) were not associated with type 1 diabetes in our dataset.
|
23152861 |
2012 |
|
Multiple Sclerosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Preliminary study: treatment with intramuscular interferon beta-1a results in increased levels of IL-12Rβ2+ and decreased levels of IL23R+ CD4+ T - Lymphocytes in multiple sclerosis.
|
22182694 |
2011 |
|
Giant Cell Arteritis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
An increased frequency of subjects carrying the minor allele A (GA+AA genotypes) of the rs3790567 IL12RB2 polymorphism was found among GCA patients compared with controls (52.8% vs 44.4%; p = 0.013, OR 1.40, 95% CI 1.06-1.85).
|
21285166 |
2011 |
|
Dermatitis, Atopic
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We showed that the rs438421 polymorphism in the IL-12RB1 (TT) gene and the rs2066446 polymorphism in the IL-12RB2 (AA) gene had a significant interaction to develop the ADe phenotype (allergic type of AD), and those individuals with the risk alleles, TT/AA/CC (IL-12RB1/IL-12RB2/IL-18), have more than a 10-fold increased risk to develop ADe.
|
20060272 |
2010 |
|
Eczema
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We showed that the rs438421 polymorphism in the IL-12RB1 (TT) gene and the rs2066446 polymorphism in the IL-12RB2 (AA) gene had a significant interaction to develop the ADe phenotype (allergic type of AD), and those individuals with the risk alleles, TT/AA/CC (IL-12RB1/IL-12RB2/IL-18), have more than a 10-fold increased risk to develop ADe.
|
20060272 |
2010 |
|
Asthma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We demonstrate the method by building two complex gene-SNP networks around Interferon Receptor 12B2 (IL12RB2) and Interleukin 1B (IL1B), two biologic candidates in asthma pathogenesis, using 534,290 genotyped variants and gene expression data on 22,177 genes from total RNA derived from peripheral blood CD4+ lymphocytes from 154 asthmatics.
|
19473523 |
2009 |
|
Carcinoma
|
0.010 |
Biomarker
|
group |
BEFREE |
We have shown previously that IL-12rb2 KO mice develop spontaneously lung adenocarcinomas or bronchioalveolar carcinomas.
|
19582164 |
2009 |