IL13, interleukin 13, 3596
N. diseases: 587; N. variants: 9
Source: ALL
| Disease | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year |
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0.100 | Biomarker | disease | BEFREE | ILC2-derived IL-13 was sufficient for RSV-driven AHR, since reconstitution of wild-type ILC2 rescued RSV-driven AHR in IL-13-deficient mice. | 31622507 | 2019 |
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0.100 | Biomarker | disease | BEFREE | We primed AALEB cells, a human bronchial epithelial cell line, with IFN-γ and IL-13, and subsequently infected the cells with respiratory syncytial virus (RSV). | 28481620 | 2017 |
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0.100 | Biomarker | disease | BEFREE | Consistent with the data from RSV-infected infants, CD4 T cell production of Interleukin (IL)-9, IL-13, and IL-17 has all been shown to contribute to RSV-induced disease in a murine model of RSV infection. | 24838148 | 2014 |
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0.100 | GeneticVariation | disease | BEFREE | Primary human bronchial epithelial (HBE) cultures, typically dominated by ciliated cells, were induced to develop goblet cell metaplasia by infection with respiratory syncytial virus (RSV) or treatment with IL-13. | 20935191 | 2011 |
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0.100 | Biomarker | disease | BEFREE | RSV induced interleukin (IL)-4 and IL-13 by murine lung and peritoneal macrophages, IL-4R alpha/STAT6-dependent AA-M phi differentiation, and significantly enhanced inflammation in the lungs of IL-4R alpha(-/-) mice. | 20404812 | 2010 |
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0.100 | AlteredExpression | disease | BEFREE | It has been shown that infection of BALB/c mice with the RSV line 19 strain but not with the RSV A2 laboratory strain results in lung IL-13 and mucus expression. | 19211758 | 2009 |
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0.100 | Biomarker | disease | BEFREE | A haplotype at IL13-1L4, which is associated with increased IL13 production, confers an increased risk of severe primary RSV bronchiolitis in early infancy. | 19131452 | 2009 |
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0.100 | AlteredExpression | disease | BEFREE | The reduction in AHR after RSV and allergen challenge in CCR1(-/-) mice was not associated with changes in peribronchial eosinophilia, but was accompanied by significantly decreased IL-13 levels in the lungs, as well as an absence of mucus cell staining within the airways. | 15593301 | 2005 |
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0.100 | AlteredExpression | disease | BEFREE | We showed that both IL-4 and IL-13 activity must be inhibited to modulate G-specific responses resulting in severe RSV-induced disease. | 12574374 | 2003 |
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0.100 | GeneticVariation | disease | BEFREE | To investigate the genetic basis for RSV disease severity, linked variants of 3 Th2 cytokine genes, IL4, IL13, and IL5 (which are clustered on chromosome 5q31.1) were characterized in 105 children who were hospitalized with severe RSV infection and 315 Korean control subjects in a pilot study. | 12402189 | 2002 |
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0.100 | Biomarker | disease | BEFREE | Treatment of RSV-infected mice with anti-IL-13 substantially inhibited airway hyperreactivity. | 11207314 | 2001 |
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0.100 | AlteredExpression | disease | BEFREE | Analysis of total pulmonary cytokine mRNA isolated 1 and 4 days following infection with rRSV/mIL-2 revealed elevated levels of mRNA for IL-2, gamma interferon (IFN-gamma), IL-4, IL-5, IL-6, IL-10, IL-13, and IL-12 p40 compared to those for wt rRSV. | 10888656 | 2000 |