IL17A, interleukin 17A, 3605

N. diseases: 1074; N. variants: 19
Disease: Intestinal fibrosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C3544347
Disease: Intestinal fibrosis
Intestinal fibrosis 		0.030 Biomarker phenotype BEFREE Treatment with anti-IL-17 antibody significantly alleviated intestinal fibrosis and reduced both mRNA and protein levels of collagen 3, TNF-α, TIMP-1, and MMP-2. 31808003 2019
CUI: C3544347
Disease: Intestinal fibrosis
Intestinal fibrosis 		0.030 Biomarker phenotype BEFREE Mechanistically, we demonstrate that Itch directly binds to HIC-5 and targets it for K63-linked ubiquitination to inhibit IL-17-driven intestinal fibrosis. 28612841 2018
CUI: C3544347
Disease: Intestinal fibrosis
Intestinal fibrosis 		0.030 Biomarker phenotype BEFREE To assess the roles of IL-17A and EMT in the initiation and development of intestinal fibrosis and to verify the potential inductive effect of IL-17A on EMT. 30097894 2018