|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Furthermore, the micron-sized MCT adjuvant was as potent as B type CpGs and clearly superior to the commonly used Alum adjuvant when total CD8<sup>+</sup>, specific p33 T cell response or tumour protection were assessed.
|
31027511 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The effect of deregulation of nuclear export mediated by exportin-1, with consequent cellular mislocalization of p33ING1b, a member of the tumor suppressor gene family, has not been previously investigated in head and neck squamous cell cancer (HNSCC).
|
29729696 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
RA induces the partnering between retinoic acid receptor (RAR) and tumor suppressor inhibitor of growth protein 1 (ING1), which prevents the formation of GADD45A and ING1 complex necessary for locus-specific Zfp423 DNA demethylation.
|
28992291 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These observations show that ING1 regulates the nucleolar epigenome and rDNA transcription suggesting that regulation of protein synthesis might serve as the basis for ING1 function as a type II tumor suppressor.
|
27903908 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A novel crosstalk between the tumor suppressors ING1 and ING2 regulates androgen receptor signaling.
|
27305909 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The inhibitor of growth-4 (ING-4) belongs to the inhibitor of growth (ING) family that is a type II tumor suppressor gene including five members (ING1-5).
|
26803518 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Inhibitor of growth 1 (ING1) is a tumor suppressor that regulates various cellular processes including cell proliferation.
|
26993046 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We find that high levels of ING1 in stroma are associated with tumor grade (p = 0.001) and size (p = 0.02), and inversely associated with patient survival (p = 0.0001) in luminal, but not in non-luminal cancers, suggesting that high stromal ING1 promotes cancer development.
|
26306560 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
30 paired normal and tumor tissues were investigated in terms of microdeletion of chromosome 13q33-34 region, ING1 expression and mutation status of ING1 and p53 genes.
|
25324173 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
ING1 levels were lower in tumors compared to adjacent normal breast tissue and correlated with tumor size (p=0.019) and distant recurrence (p=0.001) in ER- or Her2+ patients.
|
24962136 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The in vitro and in vivo assays showed that overexpression of miR-371-5p resulted in cell proliferation and increased tumor growth, which was associated with inhibitor of growth 1 (ING1) downregulation.
|
25411783 |
2014 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
ING genes (ING1-5) were identified has tumor suppressor genes.
|
24333729 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Down regulation and mislocalization of ING1 have been reported in diverse tumor types and Ser/Thr phosphorylation has been implicated in both of these processes.
|
23585863 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Recently, the ING1 and ING2 tumor suppressor status has been fully established since several studies have described the loss of ING1 and ING2 protein expression in human tumors and both ING1 and ING2 knockout mice were reported to have spontaneously developed tumors, B cell lymphomas, and soft tissue sarcomas, respectively.
|
23412501 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Previously, it was shown that cells deficient in tumour suppressor p33ING1 (ING1b) are hypersensitive to DNA damaging agents via unknown mechanism.
|
21227930 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The purpose of this study was to investigate the expressions of tumor inhibitor of growth (ING1) gene p33ING1, p53, and autophagy-related gene Beclin1 in human non-small cell lung cancer (NSCLC), and the correlation between their expressions with clinical pathological features and clinical significance.
|
21779982 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Inhibitor of Growth 1 (ING1) is recognized as candidate tumor suppressor.
|
18450387 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Inhibitor of growth 1 (ING1) is a type II tumor suppressor that affects cell function by altering chromatin structure and regulating transcription.
|
19085961 |
2009 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Our previous studies using tumor samples from patients have shown that ING1 levels are downregulated in glioblastoma multiforme (GBM), one of the most highly vascularized malignancies.
|
20066899 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Also, ING1 knockdown by siRNA accelerated transit of cells through G1 phase, consistent with ING1 serving a tumor suppressor function, and caused cells to enter apoptosis more rapidly in response to cisplatin.
|
17763999 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The Inhibitor of Growth 1 (ING1) gene has been identified and characterized as a Type-II tumor suppressor gene (TSG).
|
18636562 |
2008 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Together, our findings reveal the critical role of the H3K4me3 interaction in mediating cellular responses to genotoxic stresses and offer new insight into the molecular mechanism underlying the tumor suppressive activity of ING1.
|
18533182 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Based on similarities between the behaviour of p15(PAF) and the potential tumor suppressor product p33ING1b, we have further shown that these two proteins interact in the same complex in cell cultures.
|
16288740 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The ING1 gene is involved in the regulation of the cell cycle, senescence, and apoptosis and is a novel candidate tumor suppressor gene.
|
16465410 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Mutation of the tumour suppressor p33ING1b is rare in melanoma.
|
16792758 |
2006 |