|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
A total of 1440 patients (IDDM and NIDDM) of North European extraction attending two hospital diabetes services were initially screened by questionnaire.
|
9212310 |
1997 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, one difficulty involved in gene therapy for diabetes is a control of insulin/proinsulin production by the cells transfected with insulin cDNA.
|
9228925 |
1997 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
The single patient with the mtDNA 3243 mutation was a 56-year-old woman with IDDM, aged 39 years at diabetes onset, whose mother was diagnosed with NIDDM.
|
9313751 |
1997 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
To investigate whether recombinant human insulin-like growth factor-I (rhIGF-I) has direct effects on the insulin requirement to maintain euglycemia independent of the growth hormone (GH) level, nine subjects with insulin-dependent diabetes mellitus ([IDDM] seven females; median (range) age, duration of diabetes, and hemoglobin A1C [HbA1C], 16.9 (12.5 to 21.9) years, 11.8 (4.6 to 16.8) years, and 9.8% (7.9% to 14.1%), respectively) underwent two euglycemic studies (6:00 PM to 8:00 AM) after double-blind subcutaneous administration of rhIGF-I/placebo (40 microg/kg).
|
9440474 |
1998 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genetic structure of IDDM1: two separate regions in the major histocompatibility complex contribute to susceptibility or protection. Belgian Diabetes Registry.
|
9519723 |
1998 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Parental history of hypertension and parental history of diabetes and microvascular complications in insulin-dependent diabetes mellitus: the EURODIAB IDDM Complications Study.
|
9609365 |
1998 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We hope to emphasize instead the homogeneity of nephropathy risk in both IDDM and NIDDM and also the idea that a common genetic susceptibility exists for all types of diabetes and is conditional on cumulative exposure to hyperglycemia.
|
9649955 |
1998 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study of Asian Indian offspring of diabetic parents has shown that genetic predisposition to diabetes resulted in increased proinsulin to insulin ratio at the fasting state.
|
9768375 |
1998 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
We observed a significantly higher annual incidence (per 100,000/year) of IDDM in female subjects (1.81), older age-groups (2.25 for 8-14 years), subjects with no family history of diabetes (1.26), diabetes onset in the spring (2.20), and an increased trend over the 20 years.
|
9773722 |
1998 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Islet cell antibodies are less predictive of IDDM among unaffected children in the general population than in sibs of children with diabetes. The Childhood Diabetes in Finland Study Group.
|
9773728 |
1998 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The detection of T cell proliferation and autoantibodies to insulin in subjects with and without the protective INS VNTR-IDDM2 locus genotypes does not support the hypothesis of an allele-specific capacity for tolerance induction which could determine a susceptibility to develop autoimmunity against the insulin protein and subsequently diabetes.
|
9844045 |
1998 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
True insulin and proinsulin were measured during a 75-g OGTT in 35 individuals: 20 with normal glucose tolerance (NGT) and without diabetes among their first-degree relatives (FDR) served as controls, and 15 with NGT who were FDR of patients with NIDDM.
|
10347771 |
1999 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No linkage of P187S polymorphism in NAD(P)H: quinone oxidoreductase (NQO1/DIA4) and type 1 diabetes in the Danish population. DIEGG and DSGD. Danish IDDM Epidemiology and Genetics Group and The Danish Study Group of Diabetes in Childhood.
|
10447260 |
1999 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
We studied plasma renin, prorenin, and four polymorphic markers of the renin gene in 199 patients with IDDM and DN, and in 192 normoalbuminuric IDDM controls matched for age, sex, and duration of diabetes.
|
10462269 |
1999 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The possible association of human growth hormone (hGH) and insulin (INS) gene regions with metabolic control in diabetes was investigated in 98 subjects with non-insulin-dependent diabetes mellitus (NIDDM); 54 control subjects from the same population were also studied.
|
10778862 |
2000 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
NeuroD/BETA2 gene variability and diabetes: no associations to late-onset type 2 diabetes but an A45 allele may represent a susceptibility marker for type 1 diabetes among Danes. Danish Study Group of Diabetes in Childhood, and the Danish IDDM Epidemiology and Genetics Group.
|
10905500 |
2000 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Complete molecular scanning of the human Fas gene: mutational analysis and linkage studies in families with type I diabetes mellitus. The Danish Study Group of Diabetes in Childhood and The Danish IDDM Epidemiology and Genetics Group.
|
10907126 |
2000 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Through the design and testing of two high transcriptional activity ILPR repeats, we demonstrate that both inter- and intramolecular G-quartet formation in the ILPR can influence transcriptional activity of the human insulin gene, and thus, may contribute to that portion of diabetes susceptibility attributed to the IDDM2 locus.
|
11070077 |
2000 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
When we perturbed signalling by expressing dominant-negative forms of the receptors, FGFR1c and FGFR2b, in the pancreas, we found that that mice with attenuated FGFR1c signalling, but not those with reduced FGFR2b signalling, develop diabetes with age and exhibit a decreased number of beta-cells, impaired expression of glucose transporter 2 and increased proinsulin content in beta-cells owing to impaired expression of prohormone convertases 1/3 and 2.
|
11130726 |
2000 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taking into account that in most cases only a small proportion of islets are infiltrated by amyloid, the limited reduction in proinsulin mRNA is unlikely to play a major role in the pathogenesis of diabetes.
|
11272184 |
2001 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
It is supposed that diabetes protective genes of SHR must be located on both chromosomal segments and that these suppress the action of the essential and most important genes of diabetes development in the BB/OK rat, Iddm1, and Iddm2.
|
11327715 |
2001 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Regions of homology exist between GAD65 (residues 250-273) and the Coxsackie P2-C protein (residues 28-50) and between GAD65 (residues 506-518) and proinsulin (residues 24-36), and each of these has been reported to be a diabetes-associated T cell target.
|
11409713 |
2001 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The IDDM2 diabetes susceptibility locus maps to a minisatellite composed of a variable number of tandem repeats situated 0.5 kb upstream of INS.
|
11502799 |
2001 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings indicate that elevated proinsulin and proinsulin/insulin ratios are secondary to increased demands on beta-cell secretion induced by hyperglycemia and insulin resistance with no discernible influence of family history of diabetes.
|
11978587 |
2002 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Functional and genetic data support the hypothesis that the gene responsible for the lymphopenia, Lyp, is also a diabetes susceptibility gene, named Iddm1.
|
12031988 |
2002 |