INS, insulin, 3630

N. diseases: 405; N. variants: 37
Disease: Graves Disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0018213
Disease: Graves Disease
Graves Disease 		0.040 GeneticVariation disease BEFREE The frequency of IgG and/or IgM anti-FKBP12 autoantibodies detected by ELISA was as follows; SLE (15/39), SSc (11/27), CREST (4/7), RA (2/8), MCTD (0/5), Graves' disease (4/12), IDDM (2/6), PM/DM (0/3), MG (1/4), AIH (2/6), PBC (4/9), and healthy subjects (5/118). 10433096 1999
CUI: C0018213
Disease: Graves Disease
Graves Disease 		0.040 Biomarker disease BEFREE Patients with IDDM (n = 14), Hashimoto's thyroiditits (n = 5), and Graves' disease (n = 12), as well as healthy control subjects (n = 12), were investigated, as were four nuclear families of Graves' disease patients and two of IDDM patients. 9892247 1999
CUI: C0018213
Disease: Graves Disease
Graves Disease 		0.040 GeneticVariation disease BEFREE Since the CTLA-4-guanine at position 49 of exon 1 is associated with susceptibility to GD as well as to HT and IDDM, we investigated a recently detected cytosine/thymine substitution at position -318 within the CTLA-4 promoter region in patients with GD and HT. 9672157 1998
CUI: C0018213
Disease: Graves Disease
Graves Disease 		0.040 GeneticVariation disease BEFREE In conclusion, an alanine at codon 17 of CTLA4 is associated with genetic susceptibility to Graves' disease as well as to IDDM. 8989248 1997