|
Gestational Diabetes
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The abundance of circulating insulin gene promotor cell-free DNA (INS cfDNA) was shown to be valuable as a predictive biomarker of β-cell death in individuals with Type 1 diabetes (T1D) as well as with gestational diabetes.
|
30953560 |
2019 |
|
Gestational Diabetes
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
This study will aim to establish if fasting proinsulin concentrations at 16-18 weeks gestation will help to identify or risk stratify high-risk pregnant women with GDM.
|
30158232 |
2018 |
|
Gestational Diabetes
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Four fetal SNP alleles with the strongest univariate associations: paternally-transmitted IGF2 rs10770125 (P-value=2×10<sup>-4</sup>) and INS rs2585 (P-value=7×10<sup>-4</sup>), and maternally-transmitted KCNQ1(OT1) rs231841 (P-value=1×10<sup>-3</sup>) and KCNQ1(OT1) rs7929804 (P-value=4×10<sup>-3</sup>), were used to construct a composite fetal imprinted gene allele score which was associated with maternal glucose concentrations (P-value=4.3×10<sup>-6</sup>, n=981, r<sup>2</sup>=2.0%) and GDM prevalence (odds ratio per allele 1.44 (1.15, 1.80), P-value=1×10<sup>-3</sup>, n=89 cases and 899 controls).
|
28392167 |
2017 |
|
Gestational Diabetes
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
They are common causes of MODY (10-60%): persistent incidental childhood hyperglycemia (10-60%) and gestational diabetes mellitus (1-2%).
|
26106223 |
2015 |
|
Gestational Diabetes
|
0.100 |
Biomarker
|
phenotype |
LHGDN |
Increased skeletal muscle tumor necrosis factor-alpha and impaired insulin signaling persist in obese women with gestational diabetes mellitus 1 year postpartum.
|
18083784 |
2008 |
|
Gestational Diabetes
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
One hundred and sixty-one women with GDM and 111 normal pregnant women (n) were genotyped for INS-VNTR during the 24th-32nd pregnancy week.
|
17011062 |
2007 |
|
Gestational Diabetes
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
There were no significant differences in the frequency of the insulin gene variable number of tandem repeat ( INS VNTR) alleles and genotypes or the peroxisome proliferator-activated receptor-gamma 2 ( PPAR gamma 2-Pro12Ala) polymorphism between the women with gestational diabetes and the control women either in Arabian or in Scandinavian women.
|
15095040 |
2004 |
|
Gestational Diabetes
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Leptin expression in third trimester placenta (p) and leptin concentrations in umbilical cord blood (cb) were investigated in normal pregnancies [n = 10 (p), 31 (cb)] and abnormal pregnancies complicated with (i) maternal insulin-dependent diabetes [IDDM: n = 3 (p), 13 (cb)], (ii) gestational diabetes [GD: n = 2 (p), 10 (cb)] and (iii) fetal growth retardation [FGR: n = 5 (p), 5 (cb)].
|
10908288 |
2000 |
|
Gestational Diabetes
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Excessive secretion of proinsulin, which does not always return to normal postpartum, is often observed in women with GDM.
|
9704223 |
1998 |
|
Gestational Diabetes
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
We conducted a prospective study from birth, BABY-DIAB, among children of mothers with IDDM or gestational diabetes or fathers with IDDM, and we investigated the temporal sequence of antibody responses to islet cells (ICA), insulin (IAA), GAD (GADA), and the protein tyrosine phosphatase IA-2/ICA512 (IA-2A).
|
8666150 |
1996 |
|
Gestational Diabetes
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
We enrolled offspring of women with pregestational diabetes (this included insulin-dependent diabetes mellitus [IDDM] and non-insulin-dependent diabetes mellitus [NIDDM]) and gestational diabetes in a prospective study from 1977 through 1983.
|
8585997 |
1995 |