INS, insulin, 3630

N. diseases: 405; N. variants: 37
Disease: Prediabetes syndrome ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0362046
Disease: Prediabetes syndrome
Prediabetes syndrome 		0.040 Biomarker disease BEFREE Elevated plasma proinsulin is a sign of β-cell dysfunction in patients with diabetes/prediabetes. 31074785 2019
CUI: C0362046
Disease: Prediabetes syndrome
Prediabetes syndrome 		0.040 Biomarker disease BEFREE We conclude that increased proinsulin misfolding via disulfide-linked complexes is an early event associated with prediabetes that worsens with ß-cell dysfunction in type two diabetes. 31184302 2019
CUI: C0362046
Disease: Prediabetes syndrome
Prediabetes syndrome 		0.040 Biomarker disease BEFREE In this study, however, metformin combined with exercise training, but not exercise alone, lowered proinsulin concentrations and increased insulin clearance in adults with prediabetes. 28473613 2017
CUI: C0362046
Disease: Prediabetes syndrome
Prediabetes syndrome 		0.040 AlteredExpression disease BEFREE This study examines whether the elevated proinsulin levels that have been described in prediabetes can result from exposure of beta cells to cytokines. 10393700 1999