INS, insulin, 3630

N. diseases: 405; N. variants: 37
Disease: Pediatric Obesity ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2362324
Disease: Pediatric Obesity
Pediatric Obesity 		0.040 Biomarker disease BEFREE Rare mutations in gene PCSK1, encoding this enzyme, cause childhood obesity and abnormal glucose homeostasis with elevated proinsulin concentrations. 20534142 2010
CUI: C2362324
Disease: Pediatric Obesity
Pediatric Obesity 		0.040 Biomarker disease BEFREE In summary, our study, the largest performed so far, does not support the previously reported associations between INS VNTR and childhood obesity, insulin resistance, or birth weight, and does not suggest any major role for this variant in modulating these traits. 18388898 2008
CUI: C2362324
Disease: Pediatric Obesity
Pediatric Obesity 		0.040 GeneticVariation disease BEFREE Insulin gene variable number of tandem repeats (INS VNTR) genotype and metabolic syndrome in childhood obesity. 16868061 2006
CUI: C2362324
Disease: Pediatric Obesity
Pediatric Obesity 		0.040 GeneticVariation disease BEFREE Significant associations between INS VNTR genotype and both insulin sensitivity and secretion were apparent in infancy; these might interact with childhood appetite and nutrition to impact the development of childhood obesity and insulin resistance. 14616883 2003