|
Alzheimer's Disease
|
0.450 |
Biomarker
|
disease |
BEFREE |
These findings provide the first demonstration that small molecule modulation of microglia function <i>in vivo</i> is feasible and suggest the possibility that dual inhibition of the SHIP1 and 2 paralogs could provide a novel means to enhance basal microglial homeostatic functions for therapeutic purposes in Alzheimer's Disease, and possibly other dementias where increased microglial function could be beneficial.
|
31780579 |
2020 |
|
Alzheimer's Disease
|
0.450 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.
|
30617256 |
2019 |
|
Alzheimer's Disease
|
0.450 |
Biomarker
|
disease |
CTD_human |
Three new AD susceptibility loci, INPP5D, CD2AP, and CASS4, showed specific association with CSF tau biomarkers.
|
30320580 |
2018 |
|
Alzheimer's Disease
|
0.450 |
GeneticVariation
|
disease |
GWASCAT |
GWAS on family history of Alzheimer's disease.
|
29777097 |
2018 |
|
Alzheimer's Disease
|
0.450 |
Biomarker
|
disease |
BEFREE |
INPP5D mRNA expression in leukocytes may be a useful biomarker for the early stage of AD.
|
28482637 |
2017 |
|
Alzheimer's Disease
|
0.450 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association studies and meta-analyses implicated that increased risk of developing Alzheimer's diseases (AD) has been associated with the ABCA7, APOE, BIN1, CASS4, CD2AP, CD33, CELF1, CLU, CR1, DSG2, EPHA1, FERMT2, HLA-DRB1, HLA-DRB4, INPP5D, MEF2C, MS4A4A, MS4A4E, MS4A6E, NME8, PICALM, PLD3, PTK2B, RIN3, SLC24A4, SORL1, and ZCWPW1 genes.
|
28199971 |
2017 |
|
Alzheimer's Disease
|
0.450 |
Biomarker
|
disease |
BEFREE |
Inositol polyphosphate-5-phosphatase (INPP5D) was reported to be associated with Alzheimer's disease (AD) through modulating the inflammatory process and immune response.
|
27750211 |
2016 |
|
Alzheimer's Disease
|
0.450 |
Biomarker
|
disease |
BEFREE |
Single nucleotide polymorphisms (SNPs) in and near ABCA7, BIN1, CASS4, CD2AP, CD33, CELF1, CLU, complement receptor 1 (CR1), EPHA1, EXOC3L2, FERMT2, HLA cluster (DRB5-DQA), INPP5D, MEF2C, MS4A cluster (MS4A3-MS4A6E), NME8, PICALM, PTK2B, SLC24A4, SORL1, and ZCWPW1 have been associated with Alzheimer's disease (AD) in large meta-analyses.
|
27005436 |
2016 |
|
Alzheimer's Disease
|
0.450 |
GeneticVariation
|
disease |
GWASDB |
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.
|
24162737 |
2013 |
|
Alzheimer's Disease
|
0.450 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.
|
24162737 |
2013 |
|
Alzheimer Disease, Late Onset
|
0.310 |
Biomarker
|
disease |
CTD_human |
Quantitative Genetics Validates Previous Genetic Variants and Identifies Novel Genetic Players Influencing Alzheimer's Disease Cerebrospinal Fluid Biomarkers.
|
30320580 |
2018 |
|
Alzheimer Disease, Late Onset
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
Overall, the current evidence did not indicate that INPP5D rs35349669 polymorphism play a role in the genetic predisposition to LOAD in Chinese population.
|
27750211 |
2016 |
|
Presenile dementia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Quantitative Genetics Validates Previous Genetic Variants and Identifies Novel Genetic Players Influencing Alzheimer's Disease Cerebrospinal Fluid Biomarkers.
|
30320580 |
2018 |
|
Familial Alzheimer Disease (FAD)
|
0.300 |
Biomarker
|
disease |
CTD_human |
Quantitative Genetics Validates Previous Genetic Variants and Identifies Novel Genetic Players Influencing Alzheimer's Disease Cerebrospinal Fluid Biomarkers.
|
30320580 |
2018 |
|
Acute Confusional Senile Dementia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Quantitative Genetics Validates Previous Genetic Variants and Identifies Novel Genetic Players Influencing Alzheimer's Disease Cerebrospinal Fluid Biomarkers.
|
30320580 |
2018 |
|
Alzheimer's Disease, Focal Onset
|
0.300 |
Biomarker
|
disease |
CTD_human |
Quantitative Genetics Validates Previous Genetic Variants and Identifies Novel Genetic Players Influencing Alzheimer's Disease Cerebrospinal Fluid Biomarkers.
|
30320580 |
2018 |
|
Alzheimer Disease, Early Onset
|
0.300 |
Biomarker
|
disease |
CTD_human |
Quantitative Genetics Validates Previous Genetic Variants and Identifies Novel Genetic Players Influencing Alzheimer's Disease Cerebrospinal Fluid Biomarkers.
|
30320580 |
2018 |
|
Reperfusion Injury
|
0.300 |
Therapeutic
|
disease |
CTD_human |
Heme oxygenase-1 protects rat liver against warm ischemia/reperfusion injury via TLR2/TLR4-triggered signaling pathways.
|
25780291 |
2015 |
|
Liver Cirrhosis, Experimental
|
0.300 |
Biomarker
|
disease |
CTD_human |
Systems level analysis and identification of pathways and networks associated with liver fibrosis.
|
25380136 |
2014 |
|
Lupus Erythematosus, Systemic
|
0.210 |
AlteredExpression
|
disease |
BEFREE |
The inositol lipid phosphatases PTEN and SHIP-1 play a crucial role in maintaining B cell anergy and are reduced in expression in B cells from systemic lupus erythematosus and type 1 diabetes patients, consequent to aberrant regulation by miRNA-7 and 155.
|
31076529 |
2019 |
|
Lupus Erythematosus, Systemic
|
0.210 |
Biomarker
|
disease |
MGD |
|
|
|
|
Osteitis Deformans
|
0.200 |
Biomarker
|
disease |
MGD |
Involvement of SHIP in TLR2-induced neutrophil activation and acute lung injury.
|
15944314 |
2005 |
|
Osteitis Deformans
|
0.200 |
Biomarker
|
disease |
MGD |
SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclasts.
|
12161749 |
2002 |
|
Osteitis Deformans
|
0.200 |
Biomarker
|
disease |
MGD |
Altered responsiveness to chemokines due to targeted disruption of SHIP.
|
10606629 |
1999 |
|
Osteitis Deformans
|
0.200 |
Biomarker
|
disease |
MGD |
The src homology 2-containing inositol phosphatase (SHIP) is the gatekeeper of mast cell degranulation.
|
9736736 |
1998 |