|
Alzheimer's Disease
|
0.450 |
Biomarker
|
disease |
BEFREE |
These findings provide the first demonstration that small molecule modulation of microglia function <i>in vivo</i> is feasible and suggest the possibility that dual inhibition of the SHIP1 and 2 paralogs could provide a novel means to enhance basal microglial homeostatic functions for therapeutic purposes in Alzheimer's Disease, and possibly other dementias where increased microglial function could be beneficial.
|
31780579 |
2020 |
|
Alzheimer's Disease
|
0.450 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.
|
30617256 |
2019 |
|
Alzheimer's Disease
|
0.450 |
Biomarker
|
disease |
CTD_human |
Three new AD susceptibility loci, INPP5D, CD2AP, and CASS4, showed specific association with CSF tau biomarkers.
|
30320580 |
2018 |
|
Alzheimer's Disease
|
0.450 |
GeneticVariation
|
disease |
GWASCAT |
GWAS on family history of Alzheimer's disease.
|
29777097 |
2018 |
|
Alzheimer's Disease
|
0.450 |
Biomarker
|
disease |
BEFREE |
INPP5D mRNA expression in leukocytes may be a useful biomarker for the early stage of AD.
|
28482637 |
2017 |
|
Alzheimer's Disease
|
0.450 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association studies and meta-analyses implicated that increased risk of developing Alzheimer's diseases (AD) has been associated with the ABCA7, APOE, BIN1, CASS4, CD2AP, CD33, CELF1, CLU, CR1, DSG2, EPHA1, FERMT2, HLA-DRB1, HLA-DRB4, INPP5D, MEF2C, MS4A4A, MS4A4E, MS4A6E, NME8, PICALM, PLD3, PTK2B, RIN3, SLC24A4, SORL1, and ZCWPW1 genes.
|
28199971 |
2017 |
|
Alzheimer's Disease
|
0.450 |
Biomarker
|
disease |
BEFREE |
Inositol polyphosphate-5-phosphatase (INPP5D) was reported to be associated with Alzheimer's disease (AD) through modulating the inflammatory process and immune response.
|
27750211 |
2016 |
|
Alzheimer's Disease
|
0.450 |
Biomarker
|
disease |
BEFREE |
Single nucleotide polymorphisms (SNPs) in and near ABCA7, BIN1, CASS4, CD2AP, CD33, CELF1, CLU, complement receptor 1 (CR1), EPHA1, EXOC3L2, FERMT2, HLA cluster (DRB5-DQA), INPP5D, MEF2C, MS4A cluster (MS4A3-MS4A6E), NME8, PICALM, PTK2B, SLC24A4, SORL1, and ZCWPW1 have been associated with Alzheimer's disease (AD) in large meta-analyses.
|
27005436 |
2016 |
|
Alzheimer's Disease
|
0.450 |
GeneticVariation
|
disease |
GWASDB |
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.
|
24162737 |
2013 |
|
Alzheimer's Disease
|
0.450 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.
|
24162737 |
2013 |