|
Hyperinsulinism
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
These podocytes lose expression of the IR as a direct consequence of prolonged exposure to high insulin concentrations, which causes an increase in IR protein degradation via a proteasome-dependent and bafilomycin-sensitive pathway.
|
28852804 |
2017 |
|
Hyperinsulinism
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Individuals with only one allele for a functional insulin receptor have a tendency to hyperinsulinaemia but not to hyperglycaemia.
|
2687060 |
1989 |
|
Hyperinsulinism
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We report on a 13-year-old girl with Donohue syndrome like dysmorphism, hyperinsulinism and prolonged survival due to two novel INSR missense mutations within the insulin binding domain.
|
18411068 |
2008 |
|
Hyperinsulinism
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Recently, we reported (Huang Z., Bodkin N.L., Ortmeyer H.K., Hansen B.C., Shuldiner A. R., 1994, J Clin Invest, 94:1289-1296) that an increase in the exon 11- (i.e. lacking exon 11) (type A) IR messenger RNA (mRNA) variant in muscle is associated with hyperinsulinemia, an early risk factor for noninsulin-dependent diabetes mellitus (NIDDM), in the spontaneously obese, diabetic rhesus monkey.
|
8636366 |
1996 |
|
Hyperinsulinism
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
We concluded that vitamin D3 ameliorated insulin resistance and hyperinsulinemia in diabetic rat model received HFW through reduction of IDE and activation of insulin receptor phosphorylation.
|
27930980 |
2017 |
|
Hyperinsulinism
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Allelic variants of genes encoding components of the insulin pathway, including insulin (INS), insulin receptor (INSR), and insulin receptor substrate-1 and insulin receptor substrate-2 (IRS1 and IRS2) have been associated with hyperinsulinemia and insulin resistance and may, therefore, predict susceptibility to colorectal neoplasia.
|
17416760 |
2007 |
|
Hyperinsulinism
|
0.500 |
Biomarker
|
disease |
BEFREE |
Exposure to high insulin (100 nmol/l for 16 h) caused a significant (p<0.05-0.01) impairment of insulin receptor autophosphorylation, phosphatidyl-inositol-3 kinase activity and glycogen synthesis, but not of PC-1 protein content (114+/-3 vs 102+/-14 ng/mg protein) in HepG2 cells.
|
10707036 |
2000 |
|
Hyperinsulinism
|
0.500 |
Biomarker
|
disease |
HPO |
|
|
|
|
Hyperinsulinism
|
0.500 |
Biomarker
|
disease |
BEFREE |
The expression of the insulin receptor (IR) signaling cascade, including IR, IR substrate, phosphatidylinositol 3-kinase, Akt, and glucose transporter 4, was inhibited both in the skeletal muscle and the liver, which might be a main reason for the hyperglycemia and hyperinsulinemia.
|
28397090 |
2017 |
|
Hyperinsulinism
|
0.500 |
Biomarker
|
disease |
BEFREE |
The PA tissue growth seen in such patients is likely to result from severe in vivo hyperinsulinemia activating intact mitogenic signaling pathways emanating from the insulin receptor.
|
9486982 |
1998 |
|
Hyperinsulinism
|
0.500 |
Biomarker
|
disease |
CTD_human |
Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction.
|
10949030 |
2000 |
|
Hyperinsulinism
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Donohue syndrome ([DS]; leprechaunism) describes a genetic autosomal recessive disorder that results from the presence of homozygous or compound heterozygous mutations in the insulin receptor gene (INSR; 19p13.3-p13.2).Donohue syndrome is associated with a fatal congenital form of dwarfism with features of intrauterine and postnatal growth retardation, exaggerated hyperglycemia with hyperinsulinism and dysmorphic abnormalities.We present a case of DS owing to the rarity of this syndrome (1 case in every million births).
|
26871809 |
2016 |
|
Hyperinsulinism
|
0.500 |
Biomarker
|
disease |
BEFREE |
TRG (50 mg/kg; p.o) lowered serum glucose, fructosamine, insulin, and HOMA-IR index and increased insulin sensitivity in soleus muscle via augmenting insulin receptor autophosphorylation (IR-PH), pT308-Akt, and glucose transporter 4 (GLUT4).
|
28271502 |
2017 |
|
Hyperinsulinism
|
0.500 |
Biomarker
|
disease |
BEFREE |
Sequencing demonstrated INSR haploinsufficiency accounting for elevated insulin levels and dysglycemia.
|
19720790 |
2009 |
|
Hyperinsulinism
|
0.500 |
Biomarker
|
disease |
BEFREE |
Recombinant human IGF-I alone or combined with its binding protein (IGFBP-3) provides an alternative therapy as IGF-I receptor shares structural and functional homology with the insulin receptor and recombinant human insulin-like growth factor I (rhIGF-I) therapy could improve glucose disposal by signalling through the IGF-I receptor, whilst reducing the adverse effects of high insulin concentrations.
|
17785698 |
2007 |
|
Hyperinsulinism
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Additionally, both mRNA expressions and protein levels of insulin increased significantly in the 10 and 100 μg/L exposure groups, while transcription levels of genes encoding insulin receptor substrates decreased significantly in these groups, indicating a possibly decreased insulin sensitivity due to impairment of insulin signaling transduction downstream of insulin receptor.
|
30218961 |
2018 |
|
Hyperinsulinism
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Increased expression of IR-A during neoplastic transformation of hepatocytes could mediate some of the adverse effects of hyperinsulinemia on HCC.
|
23633480 |
2013 |
|
Hyperinsulinism
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These data suggest that the INSR polymorphism is associated with hyperinsulinemia, but not with insulin resistance, in hypertension.
|
9240761 |
1996 |
|
Hyperinsulinism
|
0.500 |
Biomarker
|
disease |
BEFREE |
The data in this paper demonstrate that IR knockdown in primary tumors partially reverses the growth-promoting effects of hyperinsulinemia as well as highlighting the importance of the insulin receptor signaling pathway in cancer progression, and more specifically in epithelial-mesenchymal transition.
|
27435064 |
2016 |
|
Hyperinsulinism
|
0.500 |
Biomarker
|
disease |
BEFREE |
These data suggest that the insulin receptor gene may contribute to insulin resistance in hypertensive patients with hyperinsulinemia.
|
7584931 |
1995 |
|
Hyperinsulinism
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Decreased IGF-IR content was accompanied by a reduction of IGF-IR/IR receptor hybrids, and therefore, increased levels of IR/IR homodimers probably explain increased insulin-stimulated receptor autophosphorylation and Akt phosphorylation.
|
16569742 |
2006 |
|
Hyperinsulinism
|
0.500 |
Biomarker
|
disease |
BEFREE |
In addition, IGF1R down-regulation increased insulin binding consistent with the formation of an increased number of holo-IR on the cell surface.
|
17210722 |
2007 |
|
Hyperinsulinism
|
0.500 |
Biomarker
|
disease |
BEFREE |
Because the nature and location of the insertion did not suggest a role in insulin-receptor function, the association of this RFLP with NIDDM and hyperinsulinemia was reexamined in a small sample of Whites.
|
2566545 |
1989 |
|
Hyperinsulinism
|
0.500 |
Biomarker
|
disease |
BEFREE |
Interestingly 48 h of fasting, leading to a decreased plasmatic insulin, increased the number of IR in the OM.
|
18752648 |
2008 |
|
Hyperinsulinism
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A 29-year-old woman developed an autoantibody to the insulin receptor (type B insulin resistance), causing extreme insulin resistance and hyperinsulinemia.
|
27911591 |
2017 |