|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
The unusual presentation in this Brazilian family enabled expansion upon a rare disease phenotype, demonstrating the possibility of detecting pancreatic malformation even in cases of PDX1 -related diabetes diagnosed after the first year of life.
|
28436541 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
This property of PDX-1 opens new strategies for the treatment of diabetes.
|
18360684 |
2008 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
We found that MST1 is strongly activated in a diabetic beta cell and induces not only its death but also directly impairs insulin secretion through promoting proteasomal degradation of key beta cell transcription factor, pancreatic and duodenal homeobox 1 (PDX1), which is critical for insulin production.Pre-clinical studies in various animal models of diabetes have reported that MST1 deficiency remarkably restores normoglycaemia and beta cell function and prevents the development of diabetes.
|
27053234 |
2016 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We demonstrate the significance of this alternative promoter in a large MODY family where a mutated IPF-1 binding site in the P2 promoter of the HNF-4alpha gene co-segregates with diabetes (LOD score 3.25).
|
11590126 |
2001 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mutations in transcription factors that play a role in the development of the endocrine pancreas, such as insulin promoter factor-1 and NeuroD1/BETA2, have been associated with diabetes.
|
11246894 |
2001 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mutations in pancreatic duodenal homeobox 1 (PDX-1) can cause a monogenic form of diabetes (maturity onset diabetes of the young 4) in humans, and silencing Pdx-1 in pancreatic β-cells of mice causes diabetes.
|
22570331 |
2012 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Several studies showed that stress can stimulate autophagy in β-cells: the number of autophagosomes is increased in different in vivo models for diabetes, such as db/db mice, mice fed high-fat diet, pdx-1 knockout mice, as well as in in vitro models of glucotoxicity and lipotoxicity.
|
21029295 |
2010 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The D76N variant of PDX1 does not significantly alter insulin secretion or act as a high-risk susceptibility allele for late-onset type 2 diabetes as proposed previously, although we cannot exclude a minor role in increasing risk of diabetes.
|
15277425 |
2004 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, PDX-1 and MafA play a crucial role in inducing surrogate beta-cells and could be a therapeutic target for diabetes.
|
17449132 |
2007 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Teucrium polium extract reverses symptoms of streptozotocin-induced diabetes in rats via rebalancing the Pdx1 and FoxO1 expressions.
|
28738518 |
2017 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interestingly, it also modulated the expression of peroxisome proliferator-activated receptor γ (PPARγ) and pancreatic and duodenal homeobox 1 (PDX-1).Our findings showed that <i>A. annulatum</i> and its bioactive compounds are capable of improving insulin secretion by pancreatic β-cells.This suggests that <i>A. annulatum</i> can be used as a therapeutic agent to treat diabetes.
|
31382473 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
All of the five known MODY genes, HNF-4alpha, glucokinase, HNF-1alpha, HNF-1beta, and IPF1, were previously excluded as being the cause of diabetes in these families.
|
10868949 |
2000 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
A positive effect of a β-adrenergic agonist on RAF-1 and PDX-1, reduction in β-cell apoptosis and improved insulin contents can help to understand the pathogenesis of diabetes and to develop novel approaches for the β-cell dysfunction in diabetes.
|
28261303 |
2017 |