Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.380 Biomarker disease BEFREE Human BMSCs expressing VEGF and PDX1 reversed hyperglycemia in more than half of the diabetic mice and induced overall improved survival and weight maintenance in all mice. 22879915 2013
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.380 Biomarker disease BEFREE Hyperglycemia recurred within 24 hours of graft removal and the histological analysis of the retrieved grafts revealed presence of Pdx1-, Nkx6.1- and C-peptide-positive cells. 23671681 2013
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.380 PosttranslationalModification disease BEFREE Overall, epigenetic modifications of PDX-1 may play a role in the development of T2D, given that pancreatic islets from patients with T2D and β-cells exposed to hyperglycemia exhibited increased DNA methylation and decreased expression of PDX-1. 22570331 2012
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.380 AlteredExpression disease BEFREE PDX-1 was decreased in MIN6N8 cells treated with high glucose or high palmitate, whereas ATF3 was increased, indicating that ATF3 plays a role in hyperglycemia or hyperlipidemia-mediated downregulation of PDX-1 expression. 21821004 2011
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.380 Biomarker disease BEFREE Pdx1-transfected adipose tissue-derived stem cells differentiate into insulin-producing cells in vivo and reduce hyperglycemia in diabetic mice. 19757377 2010
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.380 AlteredExpression disease BEFREE While acute exposure to high glucose concentrations causes an increase in PDX-1 binding, and consequently in insulin mRNA levels, chronic hyperglycemia (toxic to the beta-cell) leads to a decrease in PDX-1 and insulin levels. 12503852 2003
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.380 Biomarker disease RGD At the same time points, high hyperglycemia rats showed a global alteration in gene expression with decreased mRNA for insulin, IAPP, islet-associated transcription factors (pancreatic and duodenal homeobox-1, BETA2/NeuroD, Nkx6.1, and hepatocyte nuclear factor 1 alpha), beta-cell metabolic enzymes (glucose transporter 2, glucokinase, mitochondrial glycerol phosphate dehydrogenase, and pyruvate carboxylase), and ion channels/pumps (Kir6.2, VDCC beta, and sarcoplasmic reticulum Ca(2+)-ATPase 3). 12438314 2003
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.380 Biomarker disease BEFREE Patients with mutation in genes encoding the transcription factors, hepatocyte nuclear factor (HNF)- 1alpha, HNF-4alpha, HNF-1beta and insulin promoter factor 1 (IPF-1) have a common progressive beta-cell failure resulting in increasing hyperglycaemia and treatment requirements. 12173691 2003
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.380 Biomarker disease BEFREE Hepatic immunoreactive insulin, induced by PDX-1, was processed to mature mI-1 and mI-2 and was biologically active; it ameliorated hyperglycemia in streptozotocin-treated diabetic mice. 10909415 2000
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.380 Biomarker disease RGD In vivo prevention of hyperglycemia also prevents glucotoxic effects on PDX-1 and insulin gene expression. 10512364 1999
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.380 Biomarker disease RGD Prevention of hyperglycemia prevented the associated defects in insulin and PDX-1 gene expression and improved insulin secretion. 10512364 1999
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.380 Biomarker disease RGD These findings provide the first in vivo evidence that prevention of progressive hyperglycemia in a model of type 2 diabetes preserves insulin and PDX-1 gene expression. 10512364 1999
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.380 Biomarker disease RGD Our results demonstrate that chronic and progressive hyperglycemia resulting from type 2 diabetes in ZDF rats is associated with loss of insulin and PDX-1 mRNAs and loss of glucose-stimulated insulin secretion. 10512364 1999
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.380 Biomarker disease HPO