Lupus Erythematosus, Systemic
|
0.500 |
Biomarker
|
disease |
BEFREE |
In conclusion, JP may inhibit the activation of peritoneal macrophages in MRL/lpr mice by downregulating the IRAK1-NF-<i>κ</i>B signaling pathway, and IRAK1 may be a potential target for JP treatment of SLE.
|
31781262 |
2019 |
Lupus Erythematosus, Systemic
|
0.500 |
Biomarker
|
disease |
BEFREE |
Interleukin-1 receptor-associated kinase 1 (IRAK1) is associated with the susceptibility of SLE in humans and paeoniflorin has recently been reported to exhibit immunosuppressive properties.
|
30149133 |
2018 |
Lupus Erythematosus, Systemic
|
0.500 |
Biomarker
|
disease |
BEFREE |
In vitro experiments showed that lupus CD4<sup>+</sup> T cells had more pronounced IRAK1 phosphorylation at threonine-209 upon IL-1β stimulation than did control cells.
|
29611775 |
2018 |
Lupus Erythematosus, Systemic
|
0.500 |
Biomarker
|
disease |
BEFREE |
Therefore, IRAK1 may be a potential target for anti-inflammatory therapy for SLE and other inflammatory diseases.
|
28431280 |
2017 |
Lupus Erythematosus, Systemic
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Lupus development in BXSB mice expressing the Y chromosome autoimmunity accelerator (Yaa) increased basal and Toll-like receptor (TLR) 4/7-induced phosphorylation of mitogen-activated protein kinases, p65 nuclear factor-κB (NF-κB), enhanced tumor necrosis factor (TNF)-α and C-C motif chemokine ligand (CCL) 5 gene expression in splenic macrophages, but decreased levels of Toll-interacting protein and IRAK-M, without affecting IRAK4 or IRAK1 expression.
|
28295231 |
2017 |
Lupus Erythematosus, Systemic
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-Wide Association Study in an Amerindian Ancestry Population Reveals Novel Systemic Lupus Erythematosus Risk Loci and the Role of European Admixture.
|
26606652 |
2016 |
Lupus Erythematosus, Systemic
|
0.500 |
SusceptibilityMutation
|
disease |
ORPHANET |
These data suggest contributions of both IRAK1 and MECP2 to SLE susceptibility.
|
22904263 |
2013 |
Lupus Erythematosus, Systemic
|
0.500 |
SusceptibilityMutation
|
disease |
ORPHANET |
Our data demonstrate that the polymorphisms rs3027898 and rs1059702 of IRAK1 gene are associated with SLE in the Chinese Han population.
|
23435933 |
2013 |
Lupus Erythematosus, Systemic
|
0.500 |
SusceptibilityMutation
|
disease |
ORPHANET |
Genetics and epigenetics of systemic lupus erythematosus.
|
23943494 |
2013 |
Lupus Erythematosus, Systemic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our data demonstrate that the polymorphisms rs3027898 and rs1059702 of IRAK1 gene are associated with SLE in the Chinese Han population.
|
23435933 |
2013 |
Lupus Erythematosus, Systemic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest that the lupus-associated variant in the MECP2/IRAK1 locus has the potential to affect all 3 epigenetic mechanisms: DNA methylation, microRNA expression, and histone modification.
|
23428850 |
2013 |
Lupus Erythematosus, Systemic
|
0.500 |
Biomarker
|
disease |
BEFREE |
These data suggest contributions of both IRAK1 and MECP2 to SLE susceptibility.
|
22904263 |
2013 |
Lupus Erythematosus, Systemic
|
0.500 |
Biomarker
|
disease |
BEFREE |
As IRAK1 has been regarded a crucial gene in the pathogenesis of systemic lupus erythematosus, TRAF6 can be a Sjögren's syndrome specific biomarker, confirming and partly explaining the existance of different pathogenic pathways in the two diseases.
|
22033216 |
2012 |
Lupus Erythematosus, Systemic
|
0.500 |
SusceptibilityMutation
|
disease |
ORPHANET |
Role of cytokines in systemic lupus erythematosus: recent progress from GWAS and sequencing.
|
22654485 |
2012 |
Lupus Erythematosus, Systemic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We tested for an association with the IRAK1 SLE risk haplotype in a discovery set of 849 SSc patients and 625 controls.
|
21898345 |
2011 |
Lupus Erythematosus, Systemic
|
0.500 |
SusceptibilityMutation
|
disease |
ORPHANET |
Recent insights into the genetic basis of systemic lupus erythematosus.
|
19440199 |
2009 |
Lupus Erythematosus, Systemic
|
0.500 |
SusceptibilityMutation
|
disease |
ORPHANET |
Family-based TDT showed a significant association of SLE with a N673S polymorphism in the P-selectin gene (SELP) (P = 5.74 x 10(-6)) and a C203S polymorphism in the interleukin-1 receptor-associated kinase 1 gene (IRAK1) (P = 9.58 x 10(-6)).
|
18050247 |
2007 |
Lupus Erythematosus, Systemic
|
0.500 |
Biomarker
|
disease |
LHGDN |
Family-based TDT showed a significant association of SLE with a N673S polymorphism in the P-selectin gene (SELP) (P = 5.74 x 10(-6)) and a C203S polymorphism in the interleukin-1 receptor-associated kinase 1 gene (IRAK1) (P = 9.58 x 10(-6)).
|
18050247 |
2007 |
Lupus Erythematosus, Systemic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Family-based TDT showed a significant association of SLE with a N673S polymorphism in the P-selectin gene (SELP) (P = 5.74 x 10(-6)) and a C203S polymorphism in the interleukin-1 receptor-associated kinase 1 gene (IRAK1) (P = 9.58 x 10(-6)).
|
18050247 |
2007 |
Lupus Erythematosus, Systemic
|
0.500 |
Biomarker
|
disease |
HPO |
|
|
|
Rheumatoid Arthritis
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
MiRNA-146a rs2910164 and IRAK1 rs3027898 polymorphisms were a risk factor for predisposition to RA in codominant and dominant tested inheritance models, while, the miRNA-499 rs3746444 and PADI4 rs1748033 polymorphisms were a risk factor in codominant and recessive one.
|
29734142 |
2018 |
Rheumatoid Arthritis
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
The IRAK1 rs3027898 A allele was detected in 67% of RA patients and 70% of controls indicating that it is not associated with RA in codominant, dominant, or recessive models even after stratification by age and gender.
|
28207326 |
2017 |
Rheumatoid Arthritis
|
0.360 |
Biomarker
|
disease |
BEFREE |
Our findings indicate that RA susceptibility is associated with multiple SNPs in MECP2 and IRAK1, but high linkage disequilibrium between them does not allow for further localization.
|
23233309 |
2013 |
Rheumatoid Arthritis
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that the functional SNP IRAK1 rs3027898 C/A variant allele is associated with the development of rheumatoid arthritis.
|
22451023 |
2013 |
Rheumatoid Arthritis
|
0.360 |
Biomarker
|
disease |
CTD_human |
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
|
23143596 |
2012 |