IRF1, interferon regulatory factor 1, 3659

N. diseases: 257; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.660 Biomarker disease HPO
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.660 Biomarker disease CTD_human
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.660 CausalMutation disease CGI
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.650 Biomarker disease GENOMICS_ENGLAND
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.650 CausalMutation disease CGI
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.600 CausalMutation group CLINVAR
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.600 CausalMutation group CGI
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.600 Biomarker group CTD_human
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.380 Biomarker disease GENOMICS_ENGLAND
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.310 Biomarker disease CTD_human
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.310 Biomarker disease GENOMICS_ENGLAND
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.300 Biomarker group CTD_human
CUI: C0153943
Disease: Benign neoplasm of stomach
Benign neoplasm of stomach 		0.300 CausalMutation disease CGI
CUI: C0154060
Disease: Carcinoma in situ of stomach
Carcinoma in situ of stomach 		0.300 CausalMutation disease CGI
CUI: C0496905
Disease: Neoplasm of uncertain or unknown behavior of stomach
Neoplasm of uncertain or unknown behavior of stomach 		0.300 CausalMutation disease CGI
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer 		0.300 Biomarker disease CTD_human
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.120 CausalMutation disease CLINVAR
CUI: C0007120
Disease: Bronchioloalveolar Adenocarcinoma
Bronchioloalveolar Adenocarcinoma 		0.100 Biomarker disease HPO
CUI: C0544886
Disease: Somatic mutation
Somatic mutation 		0.100 Biomarker phenotype HPO
CUI: C4703633
Disease: Increased level of L-fucose in urine
Increased level of L-fucose in urine 		0.100 Biomarker phenotype HPO
CUI: C0042769
Disease: Virus Diseases
Virus Diseases 		0.100 AlteredExpression group BEFREE Constitutive expression of an ISGF2/IRF1 transgene leads to interferon-independent activation of interferon-inducible genes and resistance to virus infection. 1376370 1992
CUI: C0280100
Disease: Solid Neoplasm
Solid Neoplasm 		0.010 Biomarker phenotype BEFREE Molecular characterization of MAR, a multiple aberration region on human chromosome segment 12q13-q15 implicated in various solid tumors. 7539285 1995
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE The exon-skipped form of IRF-1 lacking exons 2 and 3 displayed neither DNA binding nor tumor suppressive activities. 7936656 1994
CUI: C3463824
Disease: MYELODYSPLASTIC SYNDROME
MYELODYSPLASTIC SYNDROME 		0.100 AlteredExpression group BEFREE Surprisingly, when we examined the bone marrow and peripheral mononuclear cells from patients with myelodysplastic syndrome (MDS) or leukemia secondary to MDS, we could still detect the exon-skipped form but little or none of the intact IRF-1 mRNA. 7936656 1994
CUI: C0023418
Disease: leukemia
leukemia 		0.060 AlteredExpression disease BEFREE Accelerated exon skipping of IRF-1 mRNA in human myelodysplasia/leukemia; a possible mechanism of tumor suppressor inactivation. 7936656 1994