IRF1, interferon regulatory factor 1, 3659

N. diseases: 257; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0026985
Disease: Myelodysplasia
Myelodysplasia 		0.050 AlteredExpression disease BEFREE Accelerated exon skipping of IRF-1 mRNA in human myelodysplasia/leukemia; a possible mechanism of tumor suppressor inactivation. 7936656 1994
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.040 AlteredExpression disease BEFREE Accelerated exon skipping of IRF-1 mRNA in human myelodysplasia/leukemia; a possible mechanism of tumor suppressor inactivation. 7936656 1994
CUI: C0376544
Disease: Hematopoietic Neoplasms
Hematopoietic Neoplasms 		0.010 PosttranslationalModification group BEFREE Thus this accelerated exon skipping may cause the inactivation of IRF-1 and thereby contribute to the development of human hematopoietic malignancies. 7936656 1994
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.380 GeneticVariation disease BEFREE We have investigated the allelic loss of IRF1 in a group of 12 patients with MDS and a 5q deletion and 2 patients with AML and a 5q deletion. 8219215 1993
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE Recently IRF1, a putative tumor suppressor gene localized to the long arm of chromosome 5, has been shown to be deleted from the 5q- chromosome in a group of patients with MDS and AML. 8219215 1993
CUI: C3463824
Disease: MYELODYSPLASTIC SYNDROME
MYELODYSPLASTIC SYNDROME 		0.100 GeneticVariation group BEFREE We have investigated the allelic loss of IRF1 in a group of 12 patients with MDS and a 5q deletion and 2 patients with AML and a 5q deletion. 8219215 1993
CUI: C0026985
Disease: Myelodysplasia
Myelodysplasia 		0.050 Biomarker disease BEFREE Allelic loss of IRF1 in myelodysplasia and acute myeloid leukemia: retention of IRF1 on the 5q- chromosome in some patients with the 5q- syndrome. 8219215 1993
CUI: C0740302
Disease: 5q-syndrome
5q-syndrome 		0.010 Biomarker disease BEFREE We conclude that IRF1 maps outside the commonly deleted segment of the 5q- chromosome and that loss of IRF1 is not solely responsible for the development of the 5q- syndrome. 8219215 1993
CUI: C1292779
Disease: Myelodysplastic Syndrome with Isolated del(5q)
Myelodysplastic Syndrome with Isolated del(5q) 		0.010 Biomarker disease BEFREE We conclude that IRF1 maps outside the commonly deleted segment of the 5q- chromosome and that loss of IRF1 is not solely responsible for the development of the 5q- syndrome. 8219215 1993
CUI: C1802398
Disease: Chromosome 5, trisomy 5q
Chromosome 5, trisomy 5q 		0.010 Biomarker disease BEFREE We conclude that IRF1 maps outside the commonly deleted segment of the 5q- chromosome and that loss of IRF1 is not solely responsible for the development of the 5q- syndrome. 8219215 1993
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE Although more than 30 different 5q deletions are described, recent studies have demonstrated 5q31 as the common deleted region and have mapped a tumor suppressor (IRF-1) and a cluster of interleukin genes to 5q31. 8267400 1994
CUI: C3463824
Disease: MYELODYSPLASTIC SYNDROME
MYELODYSPLASTIC SYNDROME 		0.100 Biomarker group BEFREE Thus, IRF-1 may be a critically deleted gene in human leukemia and myelodysplasia. 8438156 1993
CUI: C0023418
Disease: leukemia
leukemia 		0.060 Biomarker disease BEFREE Thus, IRF-1 may be a critically deleted gene in human leukemia and myelodysplasia. 8438156 1993
CUI: C0026985
Disease: Myelodysplasia
Myelodysplasia 		0.050 Biomarker disease BEFREE Thus, IRF-1 may be a critically deleted gene in human leukemia and myelodysplasia. 8438156 1993
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.040 Biomarker disease BEFREE Thus, IRF-1 may be a critically deleted gene in human leukemia and myelodysplasia. 8438156 1993
CUI: C0085669
Disease: Acute leukemia
Acute leukemia 		0.010 GeneticVariation disease BEFREE Inactivating rearrangements of one IRF-1 allele, accompanied by deletion of the second allele, were also identified in one case of acute leukemia. 8438156 1993
CUI: C0023798
Disease: Lipoma
Lipoma 		0.010 Biomarker disease BEFREE Using a chromosome walking approach combined with fluorescence in situ hybridization analysis, we were able to show that the chromosome 12 breakpoints involved in uterine leiomyoma, pleomorphic adenoma of the salivary gland, and lipoma cluster to the same chromosomal region, which we therefore designated MAR (multiple-aberration region). 8527387 1995
CUI: C3489413
Disease: Lipomatosis, Multiple
Lipomatosis, Multiple 		0.010 Biomarker disease BEFREE Using a chromosome walking approach combined with fluorescence in situ hybridization analysis, we were able to show that the chromosome 12 breakpoints involved in uterine leiomyoma, pleomorphic adenoma of the salivary gland, and lipoma cluster to the same chromosomal region, which we therefore designated MAR (multiple-aberration region). 8527387 1995
CUI: C0007097
Disease: Carcinoma
Carcinoma 		0.020 Biomarker group BEFREE Deletion at the APC gene locus may just be the result of large deletions on 5q and may not be important in esophageal carcinogenesis, and the IRF-1 gene or other gene(s) on 5q31.1 may be the true target of frequent deletions on 5q that may play an important role in the pathogenesis of the majority of esophageal carcinomas. 8536888 1996
CUI: C0032580
Disease: Adenomatous Polyposis Coli
Adenomatous Polyposis Coli 		0.010 GeneticVariation disease BEFREE Although many tumors exhibited large interstitial deletions on 5q that included the APC locus (5q21), we have identified minimum regions of deletion as the D5S428 locus and the interferon regulatory factor-1 (IRF-1) locus. 8564980 1996
CUI: C0033036
Disease: Atrial Premature Complexes
Atrial Premature Complexes 		0.010 GeneticVariation disease BEFREE Although many tumors exhibited large interstitial deletions on 5q that included the APC locus (5q21), we have identified minimum regions of deletion as the D5S428 locus and the interferon regulatory factor-1 (IRF-1) locus. 8564980 1996
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE IRF-1 manifests tumor suppressor activity. 8622878 1996
CUI: C0023418
Disease: leukemia
leukemia 		0.060 GeneticVariation disease BEFREE This result predicts diminished expression of PKR as a potential consequence of deletion of the IRF-1 gene in human leukemias. 8622878 1996
CUI: C0026985
Disease: Myelodysplasia
Myelodysplasia 		0.050 GeneticVariation disease BEFREE Its overexpression results in inhibition of cell growth, and deletions of the IRF-1 gene were demonstrated in a number of human leukemias and myelodysplasias. 8622878 1996
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.380 Biomarker disease BEFREE Specific DNA protein complex formation was observed with the probes from the beta-casein and IRF-1 gene promoters, but not with the ISRE oligonucleotide probe, when cell extracts from acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) were investigated. 8634413 1996