IRF1, interferon regulatory factor 1, 3659

N. diseases: 257; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009766
Disease: Allergic Conjunctivitis
Allergic Conjunctivitis 		0.200 Biomarker disease RGD Differential expression and signaling of IFN-gamma in the conjunctiva between Lewis and Brown Norway rats. 14605445 2003
CUI: C2931258
Disease: Amaurosis congenita of Leber, type 1
Amaurosis congenita of Leber, type 1 		0.010 Biomarker disease BEFREE We therefore selected this plasmid for testing in the rpe65(-/-) mouse model and observe that NP or plasmid VMD2-hRPE65-S/MAR led to structural and functional improvements in the LCA disease phenotype. 23335596 2013
CUI: C0002418
Disease: Amblyopia
Amblyopia 		0.010 Biomarker phenotype BEFREE Mild to moderate amblyopia (VA better than 0.2log MAR) was 42.9%, while severe amblyopia represented 57.1%. 29850217 2018
CUI: C0002736
Disease: Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 		0.010 GeneticVariation disease BEFREE We further show that in ALS brain tissue, neuronal ERVK reactivation is associated with the nuclear translocation of IRF1 and NF-κB isoforms p50 and p65. 27512062 2016
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.030 Biomarker disease BEFREE These findings suggest an important role of this transcription factor as an endogenous inhibitor of neointimal growth following vessel injury and it is likely that IRF-1 regulation also plays a role in the pathophysiology of primary atherosclerosis. 12499398 2003
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.030 Biomarker disease BEFREE <b>Methods</b>: We induced experimental atherosclerosis in ApoE<sup>-/-</sup>IRF1<sup>-/-</sup> mice and evaluated the effect of IRF1 on disease progression and foam cell formation. 31367250 2019
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.030 Biomarker disease BEFREE Interferon regulator factor 1/retinoic inducible gene I (IRF1/RIG-I) axis mediates 25-hydroxycholesterol-induced interleukin-8 production in atherosclerosis. 21979142 2012
CUI: C0003864
Disease: Arthritis
Arthritis 		0.010 AlteredExpression disease BEFREE We conclude that pristane enhanced autophagy, leading to a STAT1-IRF1 controlled upregulation of TLR3 expression in macrophages, is a pathogenic mechanism in the development of arthritis. 27940139 2017
CUI: C0004096
Disease: Asthma
Asthma 		0.050 GeneticVariation disease BEFREE These findings provide strong evidence of which IFN-gamma CA repeat and IRF-1 GT repeat polymorphisms influence the risk of asthma for children in Taiwan. 16961714 2006
CUI: C0004096
Disease: Asthma
Asthma 		0.050 Biomarker disease BEFREE The IRF1 locus is a strong candidate region for male-specific asthma susceptibility due to the association and validation we demonstrate here, the known role of IRF1 in asthma-relevant immune pathways and prior reports of sex-specific differences in interferon responses. 24824216 2014
CUI: C0004096
Disease: Asthma
Asthma 		0.050 GeneticVariation disease BEFREE As IRF-1 polymorphisms were shown to be associated with atopy and allergy, we comprehensively investigated effects of IRF-4 variants on allergy, asthma and related phenotypes in German children. 24074333 2013
CUI: C0004096
Disease: Asthma
Asthma 		0.050 GeneticVariation disease BEFREE We have screened the promoter and coding regions of the IRF-1 gene in atopic asthmatics and controls by SSCP method. 11069564 2000
CUI: C0004096
Disease: Asthma
Asthma 		0.050 Biomarker disease BEFREE Significant two-point linkage was observed for asthma (most significant marker IRF1, P = 0.0002) and atopy (CD14SNP, P = 0.0001). 11247662 2001
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.030 Biomarker disease BEFREE Interferon regulator factor 1/retinoic inducible gene I (IRF1/RIG-I) axis mediates 25-hydroxycholesterol-induced interleukin-8 production in atherosclerosis. 21979142 2012
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.030 Biomarker disease BEFREE These findings suggest an important role of this transcription factor as an endogenous inhibitor of neointimal growth following vessel injury and it is likely that IRF-1 regulation also plays a role in the pathophysiology of primary atherosclerosis. 12499398 2003
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.030 Biomarker disease BEFREE <b>Methods</b>: We induced experimental atherosclerosis in ApoE<sup>-/-</sup>IRF1<sup>-/-</sup> mice and evaluated the effect of IRF1 on disease progression and foam cell formation. 31367250 2019
CUI: C0033036
Disease: Atrial Premature Complexes
Atrial Premature Complexes 		0.010 GeneticVariation disease BEFREE Although many tumors exhibited large interstitial deletions on 5q that included the APC locus (5q21), we have identified minimum regions of deletion as the D5S428 locus and the interferon regulatory factor-1 (IRF-1) locus. 8564980 1996
CUI: C1332347
Disease: Atypical Ductal Breast Hyperplasia
Atypical Ductal Breast Hyperplasia 		0.010 AlteredExpression disease BEFREE Formalin-fixed paraffin-embedded archival breast tissue specimens from patients with atypical ductal hyperplasia (ADH), ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC) were examined for their expression of IRF1 and IRF5. 22053985 2011
CUI: C1510586
Disease: Autism Spectrum Disorders
Autism Spectrum Disorders 		0.010 Biomarker disease BEFREE The generation of MAR-ASD-specific epitope autoantibodies in female mice prior to breeding created a model that demonstrates for the first time that ASD-specific antigen-induced maternal autoantibodies produced alterations in a constellation of ASD-relevant behaviors. 29955164 2018
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases 		0.030 GeneticVariation group BEFREE Some of the mutated genes (SLAMF6, IRF1) have previously been associated with autoimmunity. 28635960 2017
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases 		0.030 AlteredExpression group BEFREE In the chronic forms of the disease such as Chagas Cardiomyopathy, Clone 36 RNA containing its repetitive motif may down-regulate levels of Ro52 in monocytes, fibroblasts, or T cells, allowing IRF 1 and IRF3 to continuously stimulate transcription of interferons alpha and beta, a pro-inflammatory state favoring autoimmunity. 20709399 2011
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases 		0.030 AlteredExpression group BEFREE Significantly, both IFN-γ and IL-6 were required for increased expression of IRF-1 which regulates IFN stimulated genes and is required for mHgIA. 28453771 2017
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.010 GeneticVariation disease LHGDN The authors investigated the distributions of IRF-1 promoter -415 C/A, -410 A/G, and -300 A/G, and 3'-untranslated region (UTR) A/G polymorphisms in 105 BD patients (mean age 41.7 +/- SEM 1.1 years, 44 male and 61 female) and in 105 gender- and age-matched healthy controls. 17869652 2007
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.010 GeneticVariation disease BEFREE Associations between interferon regulatory factor-1 polymorphisms and Behçet's disease. 17869652 2007
CUI: C0153943
Disease: Benign neoplasm of stomach
Benign neoplasm of stomach 		0.300 CausalMutation disease CGI