IRF1, interferon regulatory factor 1, 3659

N. diseases: 257; N. variants: 7
Disease: Tuberculosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.060 Biomarker disease BEFREE The discovery of a novel function of IRF1 in facilitating anti-mycobacterial effect through suppressing mTOR/p70 S6K signaling in Mϕs may provide a promoting therapeutic target for tuberculosis. 31226272 2019
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.060 GeneticVariation disease BEFREE None of the seven tagSNPs was individually associated with tuberculosis in the IRF1 gene. 22879909 2012
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.060 GeneticVariation disease BEFREE No evidence for association between the interferon regulatory factor 1 (IRF1) gene and clinical tuberculosis. 19028144 2009
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.060 AlteredExpression disease BEFREE STAT-1 was not activated and IRF-1 was only weakly induced after 1 day of infection by Mycobacterium tuberculosis TN913. 12654826 2003
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.060 Biomarker disease LHGDN After infection by M. tuberculosis or differentiation, intact IRF-1 was recovered. 11948194 2002
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.060 Biomarker disease LHGDN For example, although IRF-1 is required for a Th1 cell-mediated, adaptive immune response in some circumstances, it is not known if the Th1 response to infection by M. tuberculosis requires IRF-1. 11846972 2002
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.060 Biomarker disease BEFREE For example, although IRF-1 is required for a Th1 cell-mediated, adaptive immune response in some circumstances, it is not known if the Th1 response to infection by M. tuberculosis requires IRF-1. 11846972 2002