IRS1, insulin receptor substrate 1, 3667

N. diseases: 233; N. variants: 15
Disease: Anaplasia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0002793
Disease: Anaplasia
Anaplasia 		0.020 Biomarker disease BEFREE We previously reported that IRS-1 down-regulation leads to vascular smooth muscle cell (VSMC) dedifferentiation and that IRS-1 deletion from VSMCs in normoglycemic mice replicates this response. 30578299 2019
CUI: C0002793
Disease: Anaplasia
Anaplasia 		0.020 AlteredExpression disease BEFREE Here we show that deletion of IRS-1 expression in VSMCs in non-diabetic mice results in dedifferentiation, SHPS-1 activation, and aberrant signaling and that these changes parallel those that occur in response to hyperglycemia. 28003360 2017