Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The CAD also upregulated gene expression involved in obesity associated pathways (e.g., Adipoq and Irs1) in cecal tissue of rats.
|
31708891 |
2019 |
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The present study aimed to examine whether IRS1 rs2943650 was associated with obesity in Chinese children and investigate the interaction between rs2943650 and physical activity.
|
31248719 |
2019 |
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In vitro studies have demonstrated that BVR-A is a substrate of the insulin receptor and regulates IRS1 by avoiding its aberrant activation, and in animal model of obesity the loss of hepatic BVR-A has been associated with glucose/insulin alterations and fatty liver disease.However, no studies exist in humans.
|
30826467 |
2019 |
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Tumor necrosis factor-α (TNF-α), peroxisome proliferator-activated receptor-γ (PPARγ), and insulin receptor substrate-1 (IRS-1) are associated with obesity, insulin resistance, and inflammation.
|
29256014 |
2018 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
PCA restored insulin-induced phosphorylation in OB-VAT by increasing phospho-Tyr-IRS-1 and phospho-Ser-Akt after insulin stimulation as observed in NW-VAT (p < 0.05).
|
29769704 |
2018 |
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Additionally, the effects of LLAE on body weight, fat mass, glucose and lipid metabolism and the expression of PPARγ2, insulin receptor substrate 1 and glucose transporter 4 (GLUT4) in visceral adipose tissue (VAT) were measured in HFD-induced obese rats treated with low or high dose [0.5 or 3.0 g crude drug/(kg.d)] LLAE for 6 weeks.
|
28690544 |
2017 |
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Maternal obesity and offspring obesity led to reduced expression of key insulin signalling proteins, including insulin receptor substrate-1 (IRS-1).
|
28338072 |
2017 |
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Because IRS-1 is down-regulated in states of insulin resistance that occur in response to metabolic stresses such as obesity and cytokine stimulation, the findings provide a mechanism for understanding how patients with metabolic stress and/or diabetes are predisposed to developing vascular complications.
|
28003360 |
2017 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Evidence in obesity and type-2 diabetes suggests a role for a metabolic inflammasome ("metaflammasome") in mediating chronic inflammation in peripheral organs implicating IKKβ (inhibitor of nuclear factor kappa-B kinase subunit beta), IRS1 (insulin receptor substrate 1), JNK (c-jun N-terminal kinase), and PKR (double-stranded RNA protein kinase).
|
27106634 |
2017 |
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In accordance with previous studies, our findings suggest that the IRS1 G972R R allele and RR+GR genotype have protective effects for CRC in overweight/obese patients and for obesity in patients with CRC.
|
26349669 |
2016 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
This novel abnormality, increased interaction of multiple proteins with IRS1 in obesity and T2D in humans, provides new insights into the molecular mechanism of insulin resistance and identifies new targets for T2D drug development.
|
24584551 |
2014 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
In addition to known driver mutations in TP53 and CTNNB1, our mutation analysis identified non-synonymous mutations in genes implicated in metabolic diseases, i.e. diabetes and obesity: IRS1, HMGCS1, ATP8B1, PRMT6 and CLU, suggesting a common molecular etiology for HCC of alternative pathogenic origin.
|
24633315 |
2014 |
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Two variants near IRS1, rs1522813 and rs2943641, were genotyped in 738 overweight/obese adults (age 60 ± 9 years; BMI 32.7 ± 3.9 kg/m2) randomly assigned to one of four weight-loss diets (a deficit of 750 kcal/day of caloric intake from baseline) varying in macronutrient contents for 2 years.
|
24009303 |
2013 |
Obesity
|
0.600 |
Biomarker
|
disease |
CTD_human |
Obese mouse ovaries had decreased Irs1, Foxo3a, Cyp2e1, MiR-103, and MiR-21 but increased Kitlg, Akt1, and miR-184 levels relative to lean littermates.
|
23954404 |
2013 |
Obesity
|
0.600 |
Biomarker
|
disease |
RGD |
IRS-1 co-immunoprecipitation with IR-β was reduced 56% in the obese animals.
|
22982470 |
2012 |
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The aim of the present study was to determine the prevalence and association of the G972S polymorphism of the insulin receptor substrate-1 gene (IRS-1 G972S SNP) with polycystic ovary syndrome (PCOS) and insulin resistance-related traits in a distinct phenotypic group of lean PCOS women with biochemical hyperandrogenemia, excluding obesity, which is considered to be an aggravating parameter of insulin resistance.
|
20012307 |
2010 |
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to determine the incidence of the following polymorphisms in the following genes in 262 obese (BMI > or = 30) and 138 control (BMI < or = 25) subjects: leptin receptor (LEPR)-Gln223Arg, B3-adrenergic receptor (B3-AR)-Trp64Arg, serotonin transporter (5-HTT)--a 44-base pair insertion/deletion functional polymorphism in the 5-HTTLPR and insulin receptor substrate-1 (IRS-1)-Gly972Arg.
|
17124363 |
2007 |
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Patients with IRS-1 G972R were more obese at the beginning of pregnancy, had higher serum fasting insulin and glucose levels.
|
16522427 |
2006 |
Obesity
|
0.600 |
PosttranslationalModification
|
disease |
BEFREE |
In vitro studies with rapamycin suggest that mTOR/S6K1 overactivation contributes to elevated serine phosphorylation of IRS-1, leading to impaired insulin signaling to Akt in liver and muscle of this dietary model of obesity.
|
15604215 |
2005 |
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to evaluate the role of the IRS-1 gene G972R variant in 61 subjects with "uncomplicated" obesity [i.e. without diabetes, hypertension, dyslipidemia, coronary artery disease (CAD)], studied by hyperinsulinemic-euglycemic clamp.
|
15636429 |
2004 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Downregulated IRS-1 and PPARgamma in obese women with gestational diabetes: relationship to FFA during pregnancy.
|
11832353 |
2002 |
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In one family, CYP21 and IRS-1 variants were observed to co-segregate with symptoms of androgen excess and obesity.
|
12215320 |
2002 |
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Increased insulin resistance in obese children who have both 972 IRS-1 and 1057 IRS-2 polymorphisms.
|
12475767 |
2002 |
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Several studies indicate the possible role of mutations of the insulin receptor substrate-1 (IRS-1) gene in the pathogenesis of insulin-resistance and suggest a possible interaction between the IRS-1 gene and obesity, either by an effect on the development of obesity or by causing or aggravating the obesity-associated insulin resistance.
|
11317670 |
2001 |
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Defects in muscle IRS-1 expression and function have been reported in insulin-resistant states such as obesity and type 2 diabetes.
|
11641236 |
2001 |