IRS1, insulin receptor substrate 1, 3667

N. diseases: 233; N. variants: 15
Disease: Colon Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.030 Biomarker disease BEFREE We found that overexpression of alpha1-PDX and knockdown of furin expression inhibited processing of IGF-1 receptor and its subsequent activation by IGF-1 to induce IRS-1 and Akt phosphorylation, all important in colon carcinoma metastasis. 18064302 2008
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.030 GeneticVariation disease BEFREE We evaluated the effect of polymorphisms in four insulin-related genes (G972R in IRS1, G1057D in IRS2, a CA repeat in IGFI and an A/C polymorphism at -202 of IGFBP3) on the risk of microsatellite instability and KRAS2 and TP53 mutations in a population-based set of 1788 cases of colon cancer and 1981 controls. 16448675 2006
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.030 GeneticVariation disease BEFREE There was a 70% (95% CI 1.02-2.8) increased risk of colon cancer with an IRS1 R allele and the IGFBP3 AC or CC genotype. 15247132 2004