IRS1, insulin receptor substrate 1, 3667

N. diseases: 233; N. variants: 15
Disease: Tauopathies ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0949664
Disease: Tauopathies
Tauopathies 		0.020 Biomarker group BEFREE In present study, male C57BL/6 J mice were administered with PM<sub>2.5</sub> to determine whether PM<sub>2.5</sub> inhalation can induce tauopathy via the insulin resistance (IR) related pathway (IRS-1/AKT/GSK-3β signaling pathway). 30458396 2019
CUI: C0949664
Disease: Tauopathies
Tauopathies 		0.020 PosttranslationalModification group BEFREE These results provide confirmation and specificity that abnormal phosphorylation of IRS1 is a pathological feature of AD and other tauopathies, and provide support for an association between insulin resistance and abnormal tau as well as amyloid-β. 25107476 2014