IRS1, insulin receptor substrate 1, 3667

N. diseases: 233; N. variants: 15
Disease: HER2-positive carcinoma of breast ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1960398
Disease: HER2-positive carcinoma of breast
HER2-positive carcinoma of breast 		0.010 Biomarker disease BEFREE Cullin7 enhances resistance to trastuzumab therapy in Her2 positive breast cancer via degrading IRS-1 and downregulating IGFBP-3 to activate the PI3K/AKT pathway. 31461670 2019