|
Abdominal sepsis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, prolonged isoflurane exposure worsened the outcome of experimental polymicrobial abdominal sepsis and was associated with impaired neutrophil recruitment and bacterial phagocytosis via reduced LFA-1 and Mac-1 function.
|
28003439 |
2017 |
|
Acute agranulocytosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In order to provide a further control a case of acute agranulocytosis was also investigated, in which > 75% bone marrow cells were arrested at the promyelocyte stage; these bone marrow cells showed a surface phenotype identical to non-leukemic promyelocytes (CD11a+, CD11b+, CD15+, CD45R0+, CD45RA-) with a spontaneous ability to differentiate in vivo towards the more mature stages of myeloid differentiation.
|
7815843 |
1994 |
|
Acute cerebral ischemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
The underlying regulatory mechanisms regarding LFA-1 were analyzed with the treatment of si-LFA-1 and LFA-1 vector in the hippocampal CA1 area of brain tissues isolated from the rats with acute cerebral ischemia.
|
30476906 |
2018 |
|
Acute deep venous thrombosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In a group of 18 subjects with acute deep venous thrombosis (DVT), evidenced by clinical examination and echo-color-Doppler, we examined the phenotypical expression of the polymorphonuclear leukocyte (PMN) beta2-integrins (CD11a, CD11b, CD11c, CD18), obtained by using a flow cytofluorimeter.
|
16037628 |
2005 |
|
Acute Megakaryocytic Leukemias
|
0.010 |
Biomarker
|
disease |
BEFREE |
Blast cell deficiency of CD11a as a marker of acute megakaryoblastic leukemia and transient myeloproliferative disease in children with and without Down syndrome.
|
23450818 |
2014 |
|
Acute Promyelocytic Leukemia
|
0.320 |
Biomarker
|
disease |
BEFREE |
In a test group of 58 APL patients, the most predictive immune profile was HLA-DR(low), CD11a(low) (alpha(L) subunit of the leukocyte integrin LFA-1), CD18(low) (beta(2) subunit of LFA-1).
|
15108165 |
2004 |
|
Acute Promyelocytic Leukemia
|
0.320 |
Biomarker
|
disease |
CTD_human |
We demonstrate the clinical usefulness of a panel of beta2 integrins (CD11a, CD11b and CD11c) in accurate prediction of AML-M3, and recommend inclusion of this immunophenotypic analysis to identify patients who require ATRA therapy.
|
16764927 |
2007 |
|
Acute Promyelocytic Leukemia
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
ATRA was, however, incapable of promoting the up-regulation of CD11a in APL.
|
7815843 |
1994 |
|
Adenocarcinoma
|
0.010 |
Biomarker
|
group |
BEFREE |
These results indicated that LFA-1-like antigen on an adenocarcinoma cell line was a distinct molecule from LFA-1 on leukocytes.
|
7497527 |
1995 |
|
Adult Acute Megakaryoblastic Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Blast cell deficiency of CD11a as a marker of acute megakaryoblastic leukemia and transient myeloproliferative disease in children with and without Down syndrome.
|
23450818 |
2014 |
|
Adult Burkitt Lymphoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Treatment of BL cells with phorbol ester for 72 h induced expression of the beta subunit mRNA and the CD11a and CD18 antigens on the cell surface.
|
9020371 |
1997 |
|
Adult Burkitt Lymphoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Other activation antigens were unaffected by EBNA-2 expression, as were markers already expressed on the parent BL cell line, including BL markers (cALLA and BLA), proliferation markers (transferrin receptor and BK19.9), and cell adhesion-related molecules (LFA-1 and LFA-3).
|
3033649 |
1987 |
|
Adult Hodgkin Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, cells from the triplet treated for Hodgkin lymphoma in 1985 contained two subpopulations: one with high expression of CD11a that behaved like control cells and the other with low expression of CD11a that formed large tumors in vivo similar to cells from the undiagnosed triplet.
|
31582539 |
2019 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
A pair of cells, i.e., a human lymphocyte or a S KW-3 cell (human T cell leukemia), LFA-1 was expressed on which cellular surfaces, and a RBC coupled with ICAM-1, were the carriers for LFA-1 and ICAM-1.
|
11321434 |
2000 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.030 |
Biomarker
|
disease |
BEFREE |
Implications of constitutive expression of ICAM-1 for certain clinical manifestations of ATL and of depression of either ICAM-1 or LFA-1 during progression of ATL are discussed.
|
1356935 |
1992 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Adhesion of ATL cells to endothelial cells and the expression of activated form of LFA-1 were reduced by pretreatment with pertussis toxin, wortmannin, or anti-MIP-1alpha and MIP-1beta antibodies or transfection with antisense of MIP-1alpha or MIP-1beta.
|
9573029 |
1998 |
|
Aggressive Periodontitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Ex vivo studies of polymorphonuclear neutrophils from patients with early-onset periodontitis (III). CR3 and LFA-1 expression by peripheral blood and gingival crevicular polymorphonuclear neutrophils.
|
7775666 |
1995 |
|
Alveolar Bone Loss
|
0.010 |
Biomarker
|
disease |
BEFREE |
Local treatment with antibodies to IL-17 or IL-23 in LFA-1-deficient mice not only blocked inflammatory periodontal bone loss but also caused a reduction in the total bacterial burden, suggesting that the IL-17-driven pathogenesis of LAD-I periodontitis leads to dysbiosis.
|
24670684 |
2014 |
|
Alzheimer's Disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
Indeed, neutrophil depletion and the therapeutic inhibition of neutrophil trafficking, achieved by blocking LFA-1 integrin in AD mouse models, significantly reduced memory loss and the neuropathological features of AD.
|
28303140 |
2017 |
|
Alzheimer's Disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
Using CD11a, we show that PAM cells in AD transgenic brains are comprised entirely of microglia.
|
30588668 |
2019 |
|
Anemia, Sickle Cell
|
0.010 |
Biomarker
|
disease |
BEFREE |
Participation of Mac-1, LFA-1 and VLA-4 integrins in the in vitro adhesion of sickle cell disease neutrophils to endothelial layers, and reversal of adhesion by simvastatin.
|
21173096 |
2011 |
|
Ankylosing spondylitis
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
|
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The intercellular adhesion molecule-1 (ICAM-1)/leukocyte function associated antigen-1 (LFA-1) adhesion system regulates leukocyte interactions, migration, and adhesion, and appears to play an important role in atherosclerosis and thrombosis.
|
31157518 |
2019 |
|
Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Using null-allele mice and blocking mAbs, we demonstrate specifically that CD11a/CD18 (LFA-1) is absolutely required for the development of arthritis in this model.
|
15749905 |
2005 |
|
Asthma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Collectively, these observations provide new evidence demonstrating that activation of the CAM counterreceptor ligands ICAM-1 and LFA-1, both of which are endogenously expressed in ASM cells, elicits autologously upregulated IL-5 release and associated changes in ICAM-1 expression and agonist responsiveness in atopic asthmatic sensitized ASM.
|
10835320 |
2000 |