|
Atherosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The intercellular adhesion molecule-1 (ICAM-1)/leukocyte function associated antigen-1 (LFA-1) adhesion system regulates leukocyte interactions, migration, and adhesion, and appears to play an important role in atherosclerosis and thrombosis.
|
31157518 |
2019 |
|
Autoimmune Diseases
|
0.040 |
Biomarker
|
group |
BEFREE |
The beta2 integrin leukocyte function antigen-1 (LFA-1) has an important role in the pathophysiology of inflammatory and autoimmune diseases.
|
11385505 |
2001 |
|
Autoimmune Diseases
|
0.040 |
Biomarker
|
group |
BEFREE |
Lymphocyte Function Associated antigen-1(LFA-1) has been implicated severely in the pathophysiology of inflammatory and autoimmune diseases.
|
29427909 |
2018 |
|
Autoimmune Diseases
|
0.040 |
Biomarker
|
group |
BEFREE |
CD11a, a subunit of the β2-integrin LFA-1 (CD11a/CD18) with costimulatory functions, is overexpressed due to hypomethylation of its promoter regulatory elements in CD4+ T cells from patients with many autoimmune diseases.
|
22206678 |
2012 |
|
Autoimmune Diseases
|
0.040 |
Biomarker
|
group |
BEFREE |
The α<sub>L</sub>β<sub>2</sub> integrin LFA-1 is known to play a key role in T lymphocyte migration, which is necessary to mount a local immune response, and is also the main driver of autoimmune diseases.
|
28784685 |
2017 |
|
Autoimmune myocarditis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Blocking LFA-1 Aggravates Cardiac Inflammation in Experimental Autoimmune Myocarditis.
|
31627327 |
2019 |
|
Autoimmune thyroiditis
|
0.010 |
Biomarker
|
disease |
BEFREE |
We have previously shown aberrant expression of the 'leukocyte' integrin LFA-1 on epithelial cells in chronic autoimmune thyroiditis.
|
11435733 |
2001 |
|
B-Cell Lymphomas
|
0.010 |
AlteredExpression
|
group |
BEFREE |
These data suggest that CD21 is tightly related to LFA-1 expression in BCL and the absence of CD21/LFA-1 expression is associated with pleural/peritoneal fluid involvement by BCL, a potential indicator of disease progression of BCL.
|
19360456 |
2009 |
|
B-CELL MALIGNANCY, LOW-GRADE
|
0.010 |
Biomarker
|
disease |
BEFREE |
We also offer a more detailed examination of the role of LFA-1 within B-cell chronic lymphocytic leukemia.
|
29099772 |
2017 |
|
Bacterial Infections
|
0.020 |
Biomarker
|
group |
BEFREE |
Characterization of patients with an increased susceptibility to bacterial infections and a genetic deficiency of leukocyte membrane complement receptor type 3 and the related membrane antigen LFA-1.
|
3899217 |
1985 |
|
Bacterial Infections
|
0.020 |
Biomarker
|
group |
BEFREE |
Immunologic studies with LFA-1- and Mo1-deficient lymphocytes from a patient with recurrent bacterial infections.
|
3156928 |
1985 |
|
Behcet Syndrome
|
0.330 |
Biomarker
|
disease |
CTD_human |
Neutrophil adhesion to endothelial cells and factors affecting adhesion in patients with Behçet's disease.
|
8712863 |
1996 |
|
Behcet Syndrome
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
Therefore, the major genotype and haplotype of CD11a/CD18 may play a role in decreasing the susceptibility of BD, whereas the major genotype and haplotype of CD11c/CD18 may play a role in increasing the susceptibility of BD.
|
25155097 |
2014 |
|
Behcet Syndrome
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
Single nucleotide polymorphisms of CD11a and CD11c have been suggested as susceptibility loci in Korean patients with Behçet's disease (BD).
|
27309860 |
2017 |
|
Behcet Syndrome
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
DEX, Col and ILalphaD in vitro differentially affected the stimulus-dependent oxidative burst of BD and caused the down-regulation of CD11a/CD18 surface expression in neutrophils but not monocytes.
|
16428075 |
2006 |
|
Biliary Atresia
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
This was associated with hypermethylation of the CD11a promoter region in CD4+ T cells from infants with BA.
|
22206678 |
2012 |
|
Biliary cirrhosis
|
0.010 |
AlteredExpression
|
disease |
LHGDN |
Expression of adhesion molecules on mature cholangiocytes in canal of Hering and bile ductules in wedge biopsy samples of primary biliary cirrhosis.
|
16038038 |
2005 |
|
Bladder Neoplasm
|
0.010 |
Biomarker
|
disease |
LHGDN |
We investigated the role of the leukocyte-function-antigen-1 and its two subunits CD11a and CD18 in the lysis of bladder tumor cells by both effector cell populations.
|
12202941 |
2002 |
|
Blood Coagulation Disorders
|
0.010 |
GeneticVariation
|
group |
BEFREE |
In Leukocyte Adhesion Deficiency Type 3, the loss of the kindlin-3 prevents the activation of Leukocyte Function-associated Antigen-1 (LFA-1), which leads to a defect in adhesion, causing recurrent infections and bleeding disorders.
|
31329860 |
2019 |
|
Breast Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
LFA-1 gene polymorphisms are associated with the sporadic infiltrative duct breast carcinoma in Chinese Han women of Heilongjiang Province.
|
20953905 |
2011 |
|
Burkitt Lymphoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Other activation antigens were unaffected by EBNA-2 expression, as were markers already expressed on the parent BL cell line, including BL markers (cALLA and BLA), proliferation markers (transferrin receptor and BK19.9), and cell adhesion-related molecules (LFA-1 and LFA-3).
|
3033649 |
1987 |
|
Burkitt Lymphoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Treatment of BL cells with phorbol ester for 72 h induced expression of the beta subunit mRNA and the CD11a and CD18 antigens on the cell surface.
|
9020371 |
1997 |
|
Caries (morphologic abnormality)
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We detected genome-wide significant signals in KPNA4 (p value = 2.0E-9), and suggestive signals in ITGAL (p value = 2.1E-7) and PLUNC family genes (p value = 2.0E-6), thus nominating these novel loci as putative caries susceptibility genes.
|
24556642 |
2014 |
|
Carney Complex
|
0.010 |
Biomarker
|
disease |
BEFREE |
The carCTL immune synapse lacked distinct LFA-1 adhesion rings and was less reliant on LFA to form stable conjugates with target cells. carCTL receptors associated with the synapse were found to be disrupted and formed a convoluted multifocal pattern of Lck microclusters.
|
29440406 |
2018 |
|
Cerebrovascular accident
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Natural genetic variation of integrin alpha L (Itgal) modulates ischemic brain injury in stroke.
|
24130503 |
2013 |