|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
C26 cell activation with sICAM-1 enhanced their metastasizing potential in vivo, while tumor LFA-1 blockade reduced tumor burden and LSECs and HSC-derived myofibroblasts recruitment.
|
31511625 |
2019 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In addition, no association was found between LFA-1 gene polymorphisms and tumor size, and neither was it between LFA-1 gene polymorphisms and lymph node metastasis.
|
20953905 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Duplicating the events of tumor cytotoxicity, NK cells form conjugates with cryptococcal targets, rearrange the cell cytoskeleton to develop an NK immunologic synapse and release perforin-containing granules; however, each of these events occurred independently of LFA-1.
|
19261694 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Finally, we discuss the role that exosomes harboring LFA-1 play in tumor growth and metastasis.
|
29099772 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Investigating the targeting mechanism of action revealed that blockage of LFA-1 on leukosomes resulted in a 95% decrease in tumor accumulation.
|
29464004 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Disruption of LFA-1-ICAM-1 interactions, and thereby T-cell clustering, enhances the arrival of activated CD8+ T-cells to tumor draining lymph nodes in both transplanted and spontaneous cancer models.
|
30258446 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The CD11a(high) CD8(+) T-cell phenotype identifies a tumor-reactive population, which was associated in frequency and function with a SABR-induced antitumor immune response in PD-1 KO mice.
|
25701325 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Interestingly, cells from the triplet treated for Hodgkin lymphoma in 1985 contained two subpopulations: one with high expression of CD11a that behaved like control cells and the other with low expression of CD11a that formed large tumors in vivo similar to cells from the undiagnosed triplet.
|
31582539 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These results provide the first in vivo evidence that overexpression of MMP10 promotes tumor development, and indicate that MMP10 induction is an important pathway activated not only upon ICAM-1/LFA-1-mediated intercellular contact, but also following activation of tumor cells with inflammatory cytokines.
|
15356104 |
2004 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The interaction between intercellular adhesion molecules (ICAM) and the integrin leukocyte function-associated antigen-1 (LFA-1) is crucial for the regulation of several physiological and pathophysiological processes like cell-mediated elimination of tumor or virus infected cells, cancer metastasis, or inflammatory and autoimmune processes.
|
29312326 |
2017 |
|
Neoplasm Metastasis
|
0.070 |
PosttranslationalModification
|
phenotype |
BEFREE |
This mechanism is blocked by a syndecan-mimetic peptide (SSTN<sub>VEGFR2</sub>), which, by preventing VEGFR2 linkage to VLA-4, arrests tumor cell migration that depends on VLA-4 phosphorylation and stimulates the LFA-1-mediated migration of cytotoxic leukocytes.
|
31562188 |
2019 |
|
Neoplasm Metastasis
|
0.070 |
AlteredExpression
|
phenotype |
BEFREE |
Drug treatment also significantly abrogated presurgical increases in serum IL6 and C-reactive protein levels, abrogated perioperative declines in stimulated IL12 and IFNγ production, abrogated postoperative mobilization of CD16<sup>-</sup> "classical" monocytes, and enhanced expression of CD11a on circulating natural killer cells.<b>Conclusions:</b> Perioperative inhibition of COX-2 and β-adrenergic signaling provides a safe and effective strategy for inhibiting multiple cellular and molecular pathways related to metastasis and disease recurrence in early-stage breast cancer.<i></i>.
|
28490464 |
2017 |
|
Neoplasm Metastasis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
As a therapy strategy, LFA-1 antibody or Lifitegrast restrained tumor metastasis via targeting ICAM3-LFA-1 interaction.
|
29729315 |
2018 |
|
Neoplasm Metastasis
|
0.070 |
GeneticVariation
|
phenotype |
BEFREE |
The aim of the present study was to evaluate the effects of JAM-A and LFA-1 variants on the formation of colorectal cancer and metastasis.
|
31625931 |
2019 |
|
Neoplasm Metastasis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
The interaction between intercellular adhesion molecules (ICAM) and the integrin leukocyte function-associated antigen-1 (LFA-1) is crucial for the regulation of several physiological and pathophysiological processes like cell-mediated elimination of tumor or virus infected cells, cancer metastasis, or inflammatory and autoimmune processes.
|
29312326 |
2017 |
|
Neoplasm Metastasis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
Finally, we discuss the role that exosomes harboring LFA-1 play in tumor growth and metastasis.
|
29099772 |
2017 |
|
Neoplasm Metastasis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
Protumoral neutrophils expressing the lymphocyte function-associated antigen 1 (LFA-1) integrin may mediate cancer metastasis, and TGFβ1 is the major chemoattractant for neutrophils.
|
28159748 |
2017 |
|
Leukocyte adhesion deficiency type 1
|
0.060 |
Biomarker
|
disease |
BEFREE |
The dual use of CD18 and CD11a can increase testing sensitivity and prevent delayed diagnosis of LAD-1.
|
26434744 |
2016 |
|
Leukocyte adhesion deficiency type 1
|
0.060 |
Biomarker
|
disease |
BEFREE |
Local treatment with antibodies to IL-17 or IL-23 in LFA-1-deficient mice not only blocked inflammatory periodontal bone loss but also caused a reduction in the total bacterial burden, suggesting that the IL-17-driven pathogenesis of LAD-I periodontitis leads to dysbiosis.
|
24670684 |
2014 |
|
Leukocyte adhesion deficiency type 1
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
The aim of the current study was to investigate the mutations in patients diagnosed with LAD-I and functional studies of the impact of two previously reported and a novel mutation on the expression of the CD18/CD11a heterodimer.
|
28445705 |
2017 |
|
Leukocyte adhesion deficiency type 1
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Expression of the LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) antigens on COS cells was not detected, suggesting that these two mutations are sufficient to account for LAD.
|
7705401 |
1995 |
|
Leukocyte adhesion deficiency type 1
|
0.060 |
Biomarker
|
disease |
BEFREE |
Functional studies such as homotypic adhesion and adhesion to a purified counterreceptor for LFA-1, intracellular adhesion molecule-1, demonstrated that LFA-1 function had been restored in the stably transfected LAD patient cell lines.
|
1968909 |
1990 |
|
Leukocyte adhesion deficiency type 1
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
All three hCD18-LVs restored CD18 and CD11a membrane expression in LAD-I patient-derived lymphoblastoid cells.
|
27056660 |
2016 |
|
Lupus Vulgaris
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
DNA methylation changes occur in specific sequences that regulate LFA-1 expression in lupus T cells and in the hypomethylation model, indicating that altered methylation of specific genes may play a role in the pathogenesis of lupus.
|
12115234 |
2002 |
|
Lupus Vulgaris
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
RFX1 regulates CD70 and CD11a expression in lupus T cells by recruiting the histone methyltransferase SUV39H1.
|
21192791 |
2010 |