ITGAX, integrin subunit alpha X, 3687

N. diseases: 170; N. variants: 8
Disease: Pulmonary Emphysema ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0034067
Disease: Pulmonary Emphysema
Pulmonary Emphysema 		0.020 Biomarker disease BEFREE Here, we show that following chronic exposure to cigarette smoke, C3-deficient (C3(-/-)) mice develop less emphysema and have fewer CD11b(+)CD11c(+) mDCs infiltrating the lungs as compared with wild-type mice. 25465103 2015
CUI: C0034067
Disease: Pulmonary Emphysema
Pulmonary Emphysema 		0.020 GeneticVariation disease BEFREE Conditional knockout of PPARγ in APCs using Cd11c-Cre Pparg(flox/flox) mice led to spontaneous lung inflammation and emphysema that resembled the phenotype of smoke-exposed mice. 24569375 2014